Compounds > nps 1506
Page last updated: 2024-12-08

nps 1506

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

NPS 1506: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID156420
CHEMBL ID2106165
MeSH IDM0358726

Synonyms (26)

Synonym
delucemine hydrochloride (usan)
D03679
186495-99-8
delucemine hydrochloride
3,3-bis(3-fluorophenyl)-n-methylpropan-1-amine hydrochloride
benzenepropanamine, 3-fluoro-gamma-(3-fluorophenyl)-n-methyl-, hydrochloride
nps1506
nps 1506.hcl
3,3-bis-(m-fluorophenyl)-n-methylpropylamine hydrochloride
delucemine hydrochloride
unii-p110cqy44z
p110cqy44z ,
delucemine hcl
delucemine hydrochloride [usan]
nps-1506
3,3-bis-(m-fluorophenyl)-n-methylpropylamine hydrochloride
nps 1506
benzenepropanamine, 3-fluoro-.gamma.-(3-fluorophenyl)-n-methyl-, hydrochloride
nps-1506 hydrochloride
CHEMBL2106165
nps-1506 hcl
DTXSID80171909
Q27285979
186495-99-8 (hcl)
3,3-bis(3-fluorophenyl)-n-methylpropan-1-amine;hydrochloride
AKOS040748231

Research Excerpts

Overview

NPS 1506 is a moderate affinity antagonist that inhibits NMDA/glycine-induced increases in cytosolic calcium in cultured rat cerebellar granule cells. It also displaces the binding of [3H]MK-801 to rat cortical membranes.

ExcerptReferenceRelevance
"NPS 1506 is a moderate affinity, uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. "( NPS 1506, a novel NMDA receptor antagonist and neuroprotectant. Review of preclinical and clinical studies.
Artman, LD; Balandrin, MF; Brady, E; Chien, Y; Delmar, EG; George, K; Kierstead, A; Marriott, TB; Moe, ST; Mueller, AL; Newman, MK; Raszkiewicz, JL; Sanguinetti, EL; van Wagenen, BC; Wells, D, 1999)		3.19
"NPS 1506 (Fig. 1) is a moderate affinity antagonist that inhibits NMDA/glycine-induced increases in cytosolic calcium in cultured rat cerebellar granule cells (IC50 = 476nM) and displaces the binding of [3H]MK-801 to rat cortical membranes (IC50 = 664nM)."( NPS 1506, a moderate affinity uncompetitive NMDA receptor antagonist: preclinical summary and clinical experience.
Artman, LD; Balandrin, MF; Brady, E; Chien, Y; DelMar, EG; Kierstead, A; Marriott, TB; Moe, ST; Mueller, AL; Raszkiewicz, JL; VanWagenen, B; Wells, D, 2000)		2.47
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's4 (80.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.25

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.25 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.20 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.25)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (20.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other3 (60.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
fluorobenzenes
Fluorobenzenes: Derivatives of BENZENE that contain FLUORINE.. monofluorobenzene : The simplest member of the class of monofluorobenzenes that is benzene carrying a single fluoro substituent.. fluorobenzenes : Any fluoroarene that is a benzene or a substituted benzene carrying at least one fluoro group.		5.5951monofluorobenzenesNMR chemical shift reference compound
3,3-diphenylpropylamine
3,3-diphenylpropylamine: has antiextensor effect & worsens clonic seizure produced by pentylenetetrazole; RN given refers to parent cpd		3.110
dizocilpine maleate
Dizocilpine Maleate: A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.. dizocilpine maleate : A maleate salt obtained by reaction of dizocilpine with one equivalent of maleic acid.		3.3911maleate salt;
tetracyclic antidepressant		anaesthetic;
anticonvulsant;
neuroprotective agent;
nicotinic antagonist;
NMDA receptor antagonist
ConditionIndicatedRelationship StrengthStudiesTrials
Apoplexy
[description not available]		02.9110
Cerebral Ischemia
[description not available]		02.9110
Brain Ischemia
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.		02.9110
Stroke
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)		02.9110
Acute Brain Injuries
[description not available]		0210
Age-Related Memory Disorders
[description not available]		0210
Brain Injuries
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.		0210
Memory Disorders
Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.		0210
Brain Swelling
[description not available]		0210
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		0210
Closed Head Injuries
[description not available]		0210
Brain Edema
Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)		0210