Compounds > neotanshinlactone
Page last updated: 2024-11-12

neotanshinlactone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth
FloraRankFlora DefinitionFamilyFamily Definition
SalviagenusA genus in the mint family (LAMIACEAE).[MeSH]LamiaceaeThe mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH]

Cross-References

ID SourceID
PubMed CID10264769
CHEMBL ID364132
SCHEMBL ID12115014
MeSH IDM0478407

Synonyms (9)

Synonym
neo-tanshinlactone
nsc-734927
nsc734927
neo-tanschinlactone
neo-tashinlactone
CHEMBL364132
LGZUUBFLEYOEEX-UHFFFAOYSA-N
SCHEMBL12115014
6,14-dimethyl-12,17-dioxatetracyclo[8.7.0.02,7.011,15]heptadeca-1(10),2,4,6,8,11(15),13-heptaen-16-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (57)

Assay IDTitleYearJournalArticle
AID459381Cytotoxicity against human ZR-75-1 after 72 hrs by SRB assay2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents.
AID444337Cytotoxicity against human A549 cells after 3 days by SRB assay2009Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22
Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents.
AID246871Dose required for reduction in cell growth of human breast cancer MDA-MB-231 cell line2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
AID444339Cytotoxicity against human KB cells after 3 days by SRB assay2009Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22
Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents.
AID251639Percent inhibition of human skin cancer A431 cell proliferation2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
AID251651Percent inhibition of cell growth in human breast cancer MCF-7 cell line2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
AID444338Cytotoxicity against human DU145 cells after 3 days by SRB assay2009Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22
Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents.
AID251946Percent inhibition of cell growth in human AR-dependent prostate cancer LN-CaP cell line; value ranges from 28-362004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
AID459384Cytotoxicity against human DU145 after 72 hrs by SRB assay2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents.
AID459383Cytotoxicity against human A549 after 72 hrs by SRB assay2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents.
AID694263Inhibition of human recombinant telomerase activity in rabbit reticulocytes at 50 uM after 90 mins by telomerase assemblage gel electrophoresis2011Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24
ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide.
AID270140Cytotoxicity against human ZR-75-1 cells expressing ER2006Journal of medicinal chemistry, Sep-07, Volume: 49, Issue:18
Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents.
AID246845Dose required for reduction in human lung cancer A549 cell proliferation2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
AID246949Dose required for reduction in cell growth of estrogen negative human breast cancer SK-BR-3 cell line(ER-)2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
AID459386Cytotoxicity against human vincristine-resistant KBVIN after 72 hrs by SRB assay2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents.
AID251669Percent inhibition of cell growth in human breast cancer MDA-MB-231 cell line2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
AID246856Dose required for reduction in cell growth of human prostate cancer PC-3 cell line2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
AID444334Cytotoxicity against human SK-BR-3 cells after 3 days by SRB assay2009Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22
Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents.
AID270145Cytotoxicity against human SW620 cells2006Journal of medicinal chemistry, Sep-07, Volume: 49, Issue:18
Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents.
AID246952Dose required for reduction in cell growth of estrogen negative human breast cancer HS 587-T cell line(ER-)2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
AID270143Cytotoxicity against human SK-BR-3 cells expressing HER2 and lacking ER2006Journal of medicinal chemistry, Sep-07, Volume: 49, Issue:18
Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents.
AID461824Growth inhibition of human SK-BR-3 cells after 72 hrs by SRB assay2010Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues.
AID459382Cytotoxicity against human MDA-MB-231 after 72 hrs by SRB assay2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents.
AID246928Effective concentration required for 50% reduction in cell growth of human skin cancer A431 cell line2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
AID489401Cytotoxicity against human SK-BR-3 cells after 72 hrs by SRB assay2010Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14
Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents.
AID459385Cytotoxicity against human KB after 72 hrs by SRB assay2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents.
AID246964Dose required for reduction in cell growth of estrogen negative human breast cancer MDA-MB-231 cell line (ER-)2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
AID1331968Cytotoxicity against human breast cancer cells assessed as cell growth inhibition after 3 days by SRB assay2017Bioorganic & medicinal chemistry, 01-01, Volume: 25, Issue:1
Neo-tanshinlactone D-ring modified novel analogues induce apoptosis in human breast cancer cell via DNA damage.
AID489400Cytotoxicity against human DU145 cells after 72 hrs by SRB assay2010Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14
Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents.
AID270146Cytotoxicity against human KB cells2006Journal of medicinal chemistry, Sep-07, Volume: 49, Issue:18
Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents.
AID444335Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay2009Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22
Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents.
AID246953Dose required for reduction in cell growth of estrogen positive human breast cancer ZR-75-1 cell line (ER+)2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
AID461823Growth inhibition of human MCF7 cells after 72 hrs by SRB assay2010Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues.
AID246849Dose required for reduction in cell growth of human colon cancer SW620 cell line2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
AID251638Percent inhibition of cell growth in human lung cancer A549 cell line2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
AID246853Dose required for reduction in cell growth of human breast cancer MCF-7 cell line2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
AID246909Dose required for reduction in cell growth of human AR-dependent prostate cancer LN-CaP cell line2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
AID459380Cytotoxicity against human SK-BR-3 cells after 72 hrs by SRB assay2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents.
AID270139Cytotoxicity against human MCF7 cells expressing ER2006Journal of medicinal chemistry, Sep-07, Volume: 49, Issue:18
Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents.
AID444340Cytotoxicity against human KBVIN cells after 3 days by SRB assay2009Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22
Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents.
AID489403Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay2010Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14
Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents.
AID246974Dose required for reduction in cell growth of vincristine-resistant human nasopharyngeal carcinoma KB cell line2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
AID489399Cytotoxicity against human A549 cells after 72 hrs by SRB assay2010Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14
Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents.
AID246877Dose required for reduction in cell growth of human nasopharyngeal carcinoma KB cell line2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
AID444336Cytotoxicity against human MDA-MB-231 cells after 3 days by SRB assay2009Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22
Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents.
AID270141Cytotoxicity against human MDA-MB-231 cells lacking ER2006Journal of medicinal chemistry, Sep-07, Volume: 49, Issue:18
Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents.
AID251648Percent inhibition of cell growth in human colon cancer SW620 cell line2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
AID489402Cytotoxicity against human ZR-75-1 cells after 72 hrs by SRB assay2010Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14
Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents.
AID246944Dose required for reduction in cell growth of estrogen positive human breast cancer MCF-7 cell line (ER+)2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
AID270142Cytotoxicity against human HS 587-T cells lacking ER2006Journal of medicinal chemistry, Sep-07, Volume: 49, Issue:18
Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents.
AID461826Growth inhibition of human MDA-MB-231 cells after 72 hrs by SRB assay2010Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues.
AID489397Cytotoxicity against human KB cells after 72 hrs by SRB assay2010Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14
Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents.
AID251846Percent inhibition of cell growth in vincristine-resistant human nasopharyngeal carcinoma KB cell line2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
AID461825Growth inhibition of human ZR-75-1 cells after 72 hrs by SRB assay2010Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues.
AID270144Cytotoxicity against human A431 cells2006Journal of medicinal chemistry, Sep-07, Volume: 49, Issue:18
Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents.
AID489398Cytotoxicity against human KBVIN cells after 72 hrs by SRB assay2010Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14
Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents.
AID251689Percent inhibition of cell growth in human nasopharyngeal carcinoma KB cell line2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (37.50)29.6817
2010's5 (62.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
9,10-phenanthrenequinone
9,10-phenanthrenequinone: structure		2.0610phenanthrenes
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.0510taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
tanshinone
tanshinone: from root of Salvia miltiorrhiza Bunge; RN given refers to tanshinone I; cardioprotective agent and neuroprotective agent		2.4420abietane diterpenoidanticoronaviral agent
cryptotanshinone
cryptotanshinone: from Salvia miltiorrhiza		2.4420abietane diterpenoidanticoronaviral agent
tanshinone ii a
tashinone IIA: a cardiovascular agent with antineoplastic activity; isolated from Salvia miltiorrhiza; structure in first source		2.4420abietane diterpenoid
tamoxifen citrate
[no description available]		2.0210citrate saltangiogenesis inhibitor;
anticoronaviral agent
tamoxifen
[no description available]		2.0310stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		03.1450
Breast Neoplasms
Tumors or cancer of the human BREAST.		03.1450
Cancer of Lung
[description not available]		02.0510
Lung Neoplasms
Tumors or cancer of the LUNG.		02.0510