Compounds > neokestose
Page last updated: 2024-12-07

neokestose

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Neokestose is a trisaccharide composed of fructose, glucose, and fructose units linked by α(1→2), β(2→1), and β(2→1) glycosidic bonds, respectively. It is a naturally occurring sugar found in some plants, and it can also be synthesized through enzymatic reactions. Neokestose has been shown to exhibit prebiotic properties, stimulating the growth of beneficial bacteria in the gut. Research on neokestose focuses on its potential health benefits, including improved gut health, reduced inflammation, and modulation of the immune system. The study of neokestose aims to explore its applications as a functional food ingredient, a dietary supplement, and a potential therapeutic agent.'

Cross-References

ID SourceID
PubMed CID102436
CHEBI ID175865
MeSH IDM0196232

Synonyms (7)

Synonym
2-[3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-[[3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxymethyl]oxane-3,4,5-triol
CHEBI:175865
neokestose ,
6g-kestotriose
b-d-fructofuranosyl 6-o-b-d-fructofuranosyl-a-d-glucopyranoside, 8ci
neo-kestose
o-b-d-fructofuranosyl-(2->6)-a-d-glucopyranosyl b-d-fructofuranoside

Research Excerpts

Overview

Neokestose is a 6G-fructooligosaccharide (FOS) and an important prebiotic.

ExcerptReferenceRelevance
"Neokestose is a 6G-fructooligosaccharide (FOS) and an important prebiotic. "( Antineoplastic effect of a novel chemopreventive agent, neokestose, on the Caco-2 cell line via inhibition of expression of nuclear factor-κB and cyclooxygenase-2.
Chang, JY; Lee, SM; Sheu, DC; Wu, JS, 2015)		2.11

Effects

ExcerptReferenceRelevance
"Neokestose has superior prebiotic effects compared with the commercial fructooligosaccharides (FOS). "( Neokestose suppresses the growth of human melanoma A2058 cells via inhibition of the nuclear factor‑κB signaling pathway.
Chang, JY; Chen, CW; Lee, SM; Lin, MT; Sheu, DC; Wu, JS, 2017)		3.34

Treatment

ExcerptReferenceRelevance
"Treatment with neokestose led to a dose‑dependent inhibition of cell viability."( Neokestose suppresses the growth of human melanoma A2058 cells via inhibition of the nuclear factor‑κB signaling pathway.
Chang, JY; Chen, CW; Lee, SM; Lin, MT; Sheu, DC; Wu, JS, 2017)		2.24
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
oligosaccharideA compound in which monosaccharide units are joined by glycosidic linkages. The term is commonly used to refer to a defined structure as opposed to a polymer of unspecified length or a homologous mixture. When the linkages are of other types the compounds are regarded as oligosaccharide analogues.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (16.67)18.2507
2000's2 (16.67)29.6817
2010's8 (66.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.09

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.09 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index5.08 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.09)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
1-anilino-8-naphthalenesulfonate
1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.		2.1510aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
sucrose
Saccharum: A plant genus of the family POACEAE widely cultivated in the tropics for the sweet cane that is processed into sugar.		8.360glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
2,2-bis(bromomethyl)-1,3-propanediol
2,2-bis(bromomethyl)-1,3-propanediol: structure given in first source		2.7830primary alcohol
fungitetraose
nistose: structure in first source		2.0510oligosaccharide
levanbiose
levanbiose: structure given in first source		2.1710glycoside
1-kestose
1-kestose: sugar found in vegetables; structure given in first source. 1-kestose : A trisaccharide found in vegetables consisting of beta-D-fructofuranose having beta-D-fructofuranosyl and alpha-D-glucopyranosyl residues attached at the 1- and 2-positions respectively.		7.9440trisaccharide
fructans
(2->6)-beta-D-fructan : A fructan compound consisting of repeating (2->6)-beta-linked fructofuranose units.		2.5820
6-kestose
6-kestotriose : A trisaccharide that consists of sucrose having an additional fructosyl residue attached to the fructose residue via a beta-(2->6)-linkage.		7.9640trisaccharide
transforming growth factor beta
Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.		2.1510
cyclin d1
Cyclin D1: Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.		2.1510
fructooligosaccharide
[no description available]		2.7630oligosaccharide
ConditionIndicatedRelationship StrengthStudiesTrials
Malignant Melanoma
[description not available]		02.1510
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		07.1510