Compounds > napyradiomycin a1
Page last updated: 2024-12-11

napyradiomycin a1

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

napyradiomycin A1: from culture broth Chainia rubra MG802-AF1; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6438953
CHEMBL ID4204970
CHEBI ID188521
MeSH IDM0154691

Synonyms (15)

Synonym
2h-naphtho(2,3-b)pyran-5,10-dione, 3,4,4a,10a-tetrahydro-3,4a-dichloro-10a-(3,7-dimethyl-2,6-octadienyl)-6,8-dihydroxy-2,2-dimethyl-
2h-naphtho(2,3-b)pyran-5,10-dione, 3,4a-dichloro-10a-(3,7-dimethyl-2,6-octadienyl)-3,4,4a,10a-tetrahydro-6,8-dihydroxy-2,2-dimethyl-
napyradiomycin a1
103106-24-7
CHEBI:188521
(3r,4ar,10as)-3,4a-dichloro-10a-[(2e)-3,7-dimethylocta-2,6-dienyl]-6,8-dihydroxy-2,2-dimethyl-3,4-dihydrobenzo[g]chromene-5,10-dione
ws 9558 a
ws9558 a
npd-a1
napyrodiomycin a
CHEMBL4204970
HY-136824
CS-0133878
DTXSID601043827
AKOS040754762
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
menaquinonesAny prenylnaphthoquinone having a prenyl or polyprenyl group at position 3 and a methyl group at position 2 on the naphthoquinone ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (18)

Assay IDTitleYearJournalArticle
AID1378613Induction of cellular permeability in HUVEC at 20 uM by Transwell assay2017Journal of natural products, 08-25, Volume: 80, Issue:8
Identification of Antiangiogenic Potential and Cellular Mechanisms of Napyradiomycin A1 Isolated from the Marine-Derived Streptomyces sp. YP127.
AID1378606Antiinvasive activity in HUVEC assessed as inhibition of VEGF-induced cell invasion at 20 uM measured every 3 hrs for 48 hrs relative to control2017Journal of natural products, 08-25, Volume: 80, Issue:8
Identification of Antiangiogenic Potential and Cellular Mechanisms of Napyradiomycin A1 Isolated from the Marine-Derived Streptomyces sp. YP127.
AID1424115Antibacterial activity against Bacillus thuringiensis SCSIO BT012017Journal of natural products, 04-28, Volume: 80, Issue:4
Antibacterial Compounds from Marine Bacteria, 2010-2015.
AID1378602Antiproliferative activity against HUVEC assessed as inhibition of Ki67 expression at 20 uM after 24 hrs by immunofluorescent microscopic analysis2017Journal of natural products, 08-25, Volume: 80, Issue:8
Identification of Antiangiogenic Potential and Cellular Mechanisms of Napyradiomycin A1 Isolated from the Marine-Derived Streptomyces sp. YP127.
AID1378611Downregulation of VE-cadherin expression in HUVEC at 20 uM by Western blot method2017Journal of natural products, 08-25, Volume: 80, Issue:8
Identification of Antiangiogenic Potential and Cellular Mechanisms of Napyradiomycin A1 Isolated from the Marine-Derived Streptomyces sp. YP127.
AID1378600Antiproliferative activity against HUVEC after 72 hrs by Celltiter-Glo luminescent cell viability assay2017Journal of natural products, 08-25, Volume: 80, Issue:8
Identification of Antiangiogenic Potential and Cellular Mechanisms of Napyradiomycin A1 Isolated from the Marine-Derived Streptomyces sp. YP127.
AID1378607Downregulation of PECAM1 mRNA level in HUVEC at 20 uM after 24 hrs by qRT-PCR method relative to control2017Journal of natural products, 08-25, Volume: 80, Issue:8
Identification of Antiangiogenic Potential and Cellular Mechanisms of Napyradiomycin A1 Isolated from the Marine-Derived Streptomyces sp. YP127.
AID1378605Antiinvasive activity in HUVEC assessed as inhibition of VEGF-induced cell invasion at 20 uM measured every 3 hrs for 24 hrs relative to control2017Journal of natural products, 08-25, Volume: 80, Issue:8
Identification of Antiangiogenic Potential and Cellular Mechanisms of Napyradiomycin A1 Isolated from the Marine-Derived Streptomyces sp. YP127.
AID1378601Cytotoxicity against HUVEC assessed as cell death at 20 uM after 24 hrs by YOYO-1 Iodide staining based fluorescence assay2017Journal of natural products, 08-25, Volume: 80, Issue:8
Identification of Antiangiogenic Potential and Cellular Mechanisms of Napyradiomycin A1 Isolated from the Marine-Derived Streptomyces sp. YP127.
AID1378604Antimigratory activity against VEGF-stimulated HUVEC at 20 uM after 24 hrs by scratch wound-healing assay2017Journal of natural products, 08-25, Volume: 80, Issue:8
Identification of Antiangiogenic Potential and Cellular Mechanisms of Napyradiomycin A1 Isolated from the Marine-Derived Streptomyces sp. YP127.
AID1378609Downregulation of VE-cadherin mRNA level in HUVEC at 20 uM after 24 hrs by qRT-PCR method relative to control2017Journal of natural products, 08-25, Volume: 80, Issue:8
Identification of Antiangiogenic Potential and Cellular Mechanisms of Napyradiomycin A1 Isolated from the Marine-Derived Streptomyces sp. YP127.
AID1378608Downregulation of PECAM1 mRNA level in HUVEC at 20 uM after 48 hrs by qRT-PCR method relative to control2017Journal of natural products, 08-25, Volume: 80, Issue:8
Identification of Antiangiogenic Potential and Cellular Mechanisms of Napyradiomycin A1 Isolated from the Marine-Derived Streptomyces sp. YP127.
AID1424102Antibacterial activity against Staphylococcus aureus ATCC 292132017Journal of natural products, 04-28, Volume: 80, Issue:4
Antibacterial Compounds from Marine Bacteria, 2010-2015.
AID1378612Downregulation of PECAM1 expression in HUVEC at 20 uM after 24 to 48 hrs by Western blot method2017Journal of natural products, 08-25, Volume: 80, Issue:8
Identification of Antiangiogenic Potential and Cellular Mechanisms of Napyradiomycin A1 Isolated from the Marine-Derived Streptomyces sp. YP127.
AID1378610Downregulation of VE-cadherin mRNA level in HUVEC at 20 uM after 48 hrs by qRT-PCR method relative to control2017Journal of natural products, 08-25, Volume: 80, Issue:8
Identification of Antiangiogenic Potential and Cellular Mechanisms of Napyradiomycin A1 Isolated from the Marine-Derived Streptomyces sp. YP127.
AID1378599Antiangiogenic activity in HUVEC assessed as inhibition of VEGF-induced tube formation after 24 hrs by calcein-AM dye based fluorescence assay2017Journal of natural products, 08-25, Volume: 80, Issue:8
Identification of Antiangiogenic Potential and Cellular Mechanisms of Napyradiomycin A1 Isolated from the Marine-Derived Streptomyces sp. YP127.
AID1424114Antibacterial activity against Bacillus subtilis SCSIO BS012017Journal of natural products, 04-28, Volume: 80, Issue:4
Antibacterial Compounds from Marine Bacteria, 2010-2015.
AID1378603Antiproliferative activity against human BJ6 cells at 0.2 to 20 uM after 24 hrs by immunofluorescent microscopic analysis2017Journal of natural products, 08-25, Volume: 80, Issue:8
Identification of Antiangiogenic Potential and Cellular Mechanisms of Napyradiomycin A1 Isolated from the Marine-Derived Streptomyces sp. YP127.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (9.09)18.7374
1990's1 (9.09)18.2507
2000's1 (9.09)29.6817
2010's7 (63.64)24.3611
2020's1 (9.09)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.05

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.05 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index5.53 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.05)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (9.09%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (90.91%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
nalidixic acid
[no description available]		3.25101,8-naphthyridine derivative;
monocarboxylic acid;
quinolone antibiotic		antibacterial drug;
antimicrobial agent;
DNA synthesis inhibitor
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		3.2510beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
lauric acid diethanolamide
lauric acid diethanolamide: component of shampoo implicated in contact dermatitis		3.2510fatty amide
manganese dioxide
[no description available]		2.1510manganese molecular entity;
metal oxide
vanadium
Vanadium: A metallic element with the atomic symbol V, atomic number 23, and atomic weight 50.94. It is used in the manufacture of vanadium steel. Prolonged exposure can lead to chronic intoxication caused by absorption usually via the lungs.		2.1710elemental vanadium;
vanadium group element atom		micronutrient
tiletamine hydrochloride
Cyclohexanones: Cyclohexane ring substituted by one or more ketones in any position.. cyclohexanones : Any alicyclic ketone based on a cyclohexane skeleton and its substituted derivatives thereof.		2.1710
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.		1.9710benzenes;
phenyl acetates
alkenes
[no description available]		2.0510
chlorodimedone
[no description available]		2.1710
flaviolin
flaviolin: isolated from mutants of Wangiella dermatitidis; structure given in first source. flaviolin : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone having three hydroxy substituents placed at the 2-, 5- and 7-positions.		2.0510
deoxynyboquinone
deoxynyboquinone: structure in first source		3.2510
mevalonic acid
Mevalonic Acid: A dihydroxy monocarboxylic acid and precursor in the biosynthetic pathway known as the mevalonate pathway, which produces terpenes and steroids that are vital for diverse cellular functions.. mevalonic acid : A racemate composed of equimolar amounts of (R)- and (S)-mevalonic acid.. (R)-mevalonic acid : The (R)-enantiomer of mevalonic acid.		1.97103,5-dihydroxy-3-methylpentanoic acid
dactinomycin
Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)		3.2510actinomycinmutagen
naphthoquinones
Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.		3.76100
piericidin a
piericidin A: pyridine-substituted fatty alcohol antibiotic; minor descriptor (75-85); on-line & Index Medicus search ANTIBIOTICS (75-85); RN given refers to (S-(R*,R*-(all-E)))-isomer. piericidin A : A member of the class of monohydroxypyridines that acts as an irreversible mitochondrial Complex I inhibitor that strongly associates with ubiquinone binding sites in both mitochondrial and bacterial forms of NADH:ubiquinone oxidoreductase		3.2510aromatic ether;
methylpyridines;
monohydroxypyridine;
secondary allylic alcohol		antimicrobial agent;
bacterial metabolite;
EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor;
mitochondrial respiratory-chain inhibitor
novobiocin
Novobiocin: An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189). novobiocin : A coumarin-derived antibiotic obtained from Streptomyces niveus.		3.2510carbamate ester;
ether;
hexoside;
hydroxycoumarin;
monocarboxylic acid amide;
monosaccharide derivative;
phenols		antibacterial agent;
antimicrobial agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
Escherichia coli metabolite;
hepatoprotective agent
tetracycline
Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.		3.2510
ikarugamycin
ikarugamycin: structure given in first source; an antiprotozoal antibiotic isolated from Streptomyces phaeochromogenes ikaruganensis; inhibits the uptake of oxidized LDL in macrophage J774. ikarugamycin : A polyketide macrolactam containing a tetramic acid (pyrrolidine-2,4-dione) ring system. It is isolated from Streptomyces as an antibiotic with antiprotozoal and cytotoxic activities.		3.2510
merochlorin b
merochlorin B: from marine Streptomyces sp. strain CNH-189; structure in first source		2.1710
iodinin
iodinin: antibiotic pigment from Chromobacterium iodinum; structure		3.2510
merochlorin a
merochlorin A: isolated from a Streptomyces species; structure in first source		2.1710
ConditionIndicatedRelationship StrengthStudiesTrials
Angiogenesis, Pathologic
[description not available]		02.1510