n-palmitoylgalactosylsphingosine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

N-(hexadecanoyl)-beta-D-galactosylsphingosine : A D-galactosyl-N-acylsphingosine in which the ceramide N-acyl group is specified as hexadecanoyl. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	11542139
CHEBI ID	83259
MeSH ID	M0102206

Synonyms (19)

Synonym
n-palmitoylgalactosylsphingosine
34324-89-5
n-palmitoylpsychosine
CHEBI:83259
n-(hexadecanoyl)-1-beta-galactosyl-sphing-4-enine
beta-d-galactosyl-n-hexadecanoylsphingosine
n-(palmitoyl)-beta-d-galactosylsphingosine
n-hexadecanoyl-beta-d-galactosyl-sphing-4-enine
n-(hexadecanoyl)-beta-d-galactosylsphingosine
n-[(2s,3r,4e)-1-(beta-d-galactopyranosyloxy)-3-hydroxyoctadec-4-en-2-yl]hexadecanamide
beta-d-galactosyl-n-palmitoylsphingosine
n-[(e,2s,3r)-3-hydroxy-1-[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadec-4-en-2-yl]hexadecanamide
hexadecanamide, n-[(1s,2r,3e)-1-[(beta-d-galactopyranosyloxy)methyl]-2-hydroxy-3-heptadecen-1-yl]-
n-palmitoyl cerebroside
Q27105092
hexadecanamide,n-[(1s,2r,3e)-1-[(beta-d-galactopyranosyloxy)methyl]-2-hydroxy-3-heptadecen-1-yl]-
DTXSID901120367
n-[(1s,2r,3e)-1-[(beta-d-galactopyranosyloxy)methyl]-2-hydroxy-3-heptadecen-1-yl]hexadecanamide
c16 galactosylceramide (d18:1/16:0)

Research Excerpts

Toxicity

Excerpt	Reference	Relevance
"After 6 months, the EYEMATE-SC sensor was safe and well tolerated, and allowed continual IOP monitoring."	( Safety and performance of a suprachoroidal sensor for telemetric measurement of intraocular pressure in the EYEMATE-SC trial. Dick, HB; Hoffmann, EM; Mackert, M; Mansouri, K; Mermoud, A; Rao, HL; Seuthe, AM; Szurman, P; Weinreb, RN, 2023)	0.91
"Device position and adverse events."	( EYEMATE-SC Trial: Twelve-Month Safety, Performance, and Accuracy of a Suprachoroidal Sensor for Telemetric Measurement of Intraocular Pressure. Dick, HB; Gillmann, K; Hoffmann, EM; Mackert, MJ; Mansouri, K; Mermoud, A; Rao, HL; Seuthe, AM; Szurman, P; Weinreb, RN, 2023)	0.91
"The EYEMATE-SC sensor was safe and well tolerated through 12 months."	( EYEMATE-SC Trial: Twelve-Month Safety, Performance, and Accuracy of a Suprachoroidal Sensor for Telemetric Measurement of Intraocular Pressure. Dick, HB; Gillmann, K; Hoffmann, EM; Mackert, MJ; Mansouri, K; Mermoud, A; Rao, HL; Seuthe, AM; Szurman, P; Weinreb, RN, 2023)	0.91

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

Role	Description
mouse metabolite	Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

Class	Description
N-acyl-beta-D-galactosylsphingosine	An N-acyl-D-galactosylsphingosine in which the anomeric configuration of the galactosyl residue is beta; sphingosine substituted at the O-1 position by a beta-D-galactosyl group and at the N-2 position by an acyl group.
HexCer(d18:1/16:0)	A cerebroside in which the ceramide N-acyl group is specified as hexadecanoyl.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (13)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	6 (46.15)	18.7374
1990's	3 (23.08)	18.2507
2000's	1 (7.69)	29.6817
2010's	0 (0.00)	24.3611
2020's	3 (23.08)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (7.69%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (92.31%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
nickel Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.. nickel ion : A nickel atom having a net electric charge.. nickel atom : Chemical element (nickel group element atom) with atomic number 28.	2.6	1	metal allergen; nickel group element atom	epitope; micronutrient
palmitic acid Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.. hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.	1.99	1	long-chain fatty acid; straight-chain saturated fatty acid	algal metabolite; Daphnia magna metabolite; EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor; plant metabolite
deuterium Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.	2.38	2	dihydrogen
1,2-dipalmitoyl-3-phosphatidylethanolamine 1,2-dipalmitoyl-3-phosphatidylethanolamine: RN given refers to parent cpd without isomeric designation	1.97	1
i(3)so3-galactosylceramide Sulfoglycosphingolipids: GLYCOSPHINGOLIPIDS with a sulfate group esterified to one of the sugar groups.. 1-(3-O-sulfo-beta-D-galactosyl)-N-tetracosanoylsphingosine : A D-galactosyl-N-acylsphingosine having a sulfo group at the 3-position on the galactose ring and tetracosanoyl as the N-acyl group.	2	1	galactosylceramide sulfate; N-acyl-beta-D-galactosylsphingosine
phosphatidylcholines Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.	1.96	1	1,2-diacyl-sn-glycero-3-phosphocholine
galactocerebroside galactocerebroside: a NITROGEN containing sphingolipid	1.98	1

Condition	Relationship Strength	Studies	Trials
Chronic Primary Open Angle Glaucoma [description not available]	5.31	2	1
Glaucoma, Open-Angle Glaucoma in which the angle of the anterior chamber is open and the trabecular meshwork does not encroach on the base of the iris.	5.31	2	1
Intraocular Pressure The pressure of the fluids in the eye.	5.31	2	1

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