n-nitroso-2-hydroxymorpholine profile

N-nitroso-2-hydroxymorpholine (NHM) is a potent carcinogen that has been found in various food products. It is formed as a by-product during the nitrosation of secondary amines, a process that can occur during food processing or storage. NHM is particularly concerning due to its high carcinogenic potential, which has been demonstrated in animal studies. Its formation can be influenced by factors such as pH, temperature, and the presence of nitrite, highlighting the importance of controlling these factors during food production to minimize its formation. Research into NHM focuses on understanding its formation mechanisms, its occurrence in different food matrices, and developing methods to prevent or reduce its formation. This research is crucial to ensure food safety and protect public health.'

N-nitroso-2-hydroxymorpholine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	107887
SCHEMBL ID	10413792
MeSH ID	M0128683

Synonym
morpholinol, 4-nitroso-
106900-25-8
67587-52-4
4-nitrosomorpholin-2-ol
n-nitroso-2-hydroxymorpholine
ccris 2914
4-nitroso-2-morpholinol
4-nitrosomorpholinol
AKOS006278728
102996-61-2
SCHEMBL10413792
DTXSID0020995

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	6 (75.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (25.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetaldehyde Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.. acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.. aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.. acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.	2.37	2	aldehyde	carcinogenic agent; EC 3.5.1.4 (amidase) inhibitor; electron acceptor; Escherichia coli metabolite; human metabolite; mouse metabolite; mutagen; oxidising agent; Saccharomyces cerevisiae metabolite; teratogenic agent
adenine [no description available]	2	1	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
cytosine [no description available]	2	1	aminopyrimidine; pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
formaldehyde paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy	1.96	1	aldehyde; one-carbon compound	allergen; carcinogenic agent; disinfectant; EC 3.5.1.4 (amidase) inhibitor; environmental contaminant; Escherichia coli metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
glycolaldehyde [no description available]	1.96	1	glycolaldehydes	fundamental metabolite; human metabolite
diethylnitrosamine Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.. N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.	3.36	7	nitrosamine	carcinogenic agent; hepatotoxic agent; mutagen
n-nitrosomorpholine N-nitrosomorpholine : A nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco.	7.66	3	nitrosamine	carcinogenic agent; mutagen
glyoxal [no description available]	2.39	2	dialdehyde	agrochemical; allergen; pesticide; plant growth regulator
n-nitrosodiethanolamine [no description available]	3.22	6	nitroso compound
n-nitrosoiminodiacetic acid [no description available]	1.96	1
n-(2-hydroxyethyl)-n-carboxymethylnitrosamine N-(2-hydroxyethyl)-N-carboxymethylnitrosamine: N-nitrosodiethanolamine metabolite in rat urine	1.96	1
fenton's reagent Fenton's reagent: used for oxidizing sugars & alcohols	1.96	1
deoxyguanosine [no description available]	7.39	2	purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
guanine [no description available]	2	1	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
phosphorus radioisotopes Phosphorus Radioisotopes: Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.	2.01	1

Condition	Relationship Strength	Studies
Adenocarcinoma, Basal Cell [description not available]	1.97	1
Angiosarcoma [description not available]	1.97	1
Cancer of Liver [description not available]	1.97	1
Experimental Hepatoma [description not available]	1.97	1
Cancer of Lung [description not available]	1.97	1
Experimental Neoplasms [description not available]	1.97	1
Cancer of the Thyroid [description not available]	1.97	1
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	1.97	1
Hemangiosarcoma A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed)	1.97	1
Liver Neoplasms Tumors or cancer of the LIVER.	1.97	1
Lung Neoplasms Tumors or cancer of the LUNG.	1.97	1
Thyroid Neoplasms Tumors or cancer of the THYROID GLAND.	1.97	1
Cell Transformation, Viral An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.	1.96	1

n-nitroso-2-hydroxymorpholine

Description

Cross-References

Synonyms (12)

Research

Studies (8)

Market Indicators

Research Demand Index: 11.98

Study Types