Compounds > n,n-dimethyl-2-((4'-(thien-2''-yl)pyrimidin-2'-yl)thio)ethylamine
Page last updated: 2024-12-07

n,n-dimethyl-2-((4'-(thien-2''-yl)pyrimidin-2'-yl)thio)ethylamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N,N-dimethyl-2-((4'-(thien-2''-yl)pyrimidin-2'-yl)thio)ethylamine: phleomycin amplifier; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID122632
CHEMBL ID283729
SCHEMBL ID4239842
MeSH IDM0144152

Synonyms (12)

Synonym
n,n-dimethyl-2-[4-(2-thienyl)pyrimidin-2-yl]sulfanyl-ethanamine
n,n-dimethyl-2-[[4-(2-thienyl)pyrimidine-4'-yl]thio]ethylamine - unfused bicyclic pyrimidine derivative
ethanamine, n,n-dimethyl-2-[[4-(2-thienyl)-2-pyrimidinyl]thio]-
83726-78-7
4-thienyl-2-setnme2-pyrimidine
n,n-dimethyl-2-((4'-(thien-2''-yl)pyrimidin-2'-yl)thio)ethylamine
dmtpte
ethanamine, n,n-dimethyl-2-((4-(2-thienyl)-2-pyrimidinyl)thio)-
CHEMBL283729
n,n-dimethyl-2-(4-thiophen-2-ylpyrimidin-2-yl)sulfanylethanamine
DTXSID00232581
SCHEMBL4239842
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID384542Activity at IFNAR in human Daudi cells assessed as induction of stat1 tyrosine phosphorylation at 100 umol after 5 to 30 mins2008Journal of medicinal chemistry, May-08, Volume: 51, Issue:9
De novo design of nonpeptidic compounds targeting the interactions between interferon-alpha and its cognate cell surface receptor.
AID50755In vitro cytotoxicity against human colon carcinoma (Colon-205) cells1999Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18
Synthesis and antitumor activity of bithienyl-pyrimidine derivatives with electrostatic binding side chains.
AID95846In vitro cytotoxicity against human oral epidermoid carcinoma (KB) cells1999Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18
Synthesis and antitumor activity of bithienyl-pyrimidine derivatives with electrostatic binding side chains.
AID54453Binding constant to DNA measured spectrophotometrically1988Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
Molecular basis for bleomycin amplification: conformational and stereoelectronic effects in unfused amplifiers.
AID54452Activity against DNA binding in calf thymus was determined1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Amplification of bleomycin-mediated degradation of DNA.
AID55473Evaluated for binding affinity with DNA at a pH of 8 by Fluorimetric method; 50% loss of initial fluorescent cannot achieve.1999Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18
Synthesis and antitumor activity of bithienyl-pyrimidine derivatives with electrostatic binding side chains.
AID86202In vitro cytotoxicity against human larynx carcinoma (Hep-2)1999Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18
Synthesis and antitumor activity of bithienyl-pyrimidine derivatives with electrostatic binding side chains.
AID88544In vitro cytotoxicity against human cervical carcinoma (Hela) cells at dose 50 ug/mL1999Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18
Synthesis and antitumor activity of bithienyl-pyrimidine derivatives with electrostatic binding side chains.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (60.00)18.7374
1990's1 (20.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.42

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.42 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.42)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
thiophenes
Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.		1.9610mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
ethidium bromide
[no description available]		1.9710organic bromide saltgeroprotector;
intercalator;
trypanocidal drug
phleomycins
Phleomycins: Water-soluble, copper-containing low molecular weight polypeptides obtained from the culture medium of Streptomyces verticillus. They are specific inhibitors of DNA synthesis in bacteria and have been found to act as antitumor agents. They have also been used against rust fungi of plants.. phleomycin : A mixture of glycopeptide antibiotics originally isolated from the bacterium Streptomyces verticillus whose components all contain a thiazolinylthiazole moiety and can form complexes with redox-active metals such as Co, Cu, and Fe. (Bleomycins are very similar to phleomycins, but have a bithiazole moiety in place of the thiazolinylthiazole moiety).		1.9610
ConditionIndicatedRelationship StrengthStudiesTrials