Page last updated: 2024-12-06

n,n'-diacetylhydrazine

N,N'-Diacetylhydrazine, also known as 1,2-diacetylhydrazine, is a white crystalline solid that is commonly used as a precursor in the synthesis of various chemical compounds. Its synthesis involves the reaction of hydrazine with acetic anhydride. The compound exhibits interesting biological activities, such as antitumor and anti-inflammatory effects, making it a subject of extensive research in the field of medicinal chemistry. Its potential applications in pharmaceuticals and agrochemicals are also being explored. The molecule's ability to form metal complexes has garnered attention in the field of coordination chemistry, leading to studies on its complexation behavior with different metal ions.'

Cross-References

ID SourceID
PubMed CID72884
CHEMBL ID3091852
CHEBI ID80616
SCHEMBL ID606948
SCHEMBL ID23224226
MeSH IDM0124787

Synonyms (45)

Synonym
1.2-diacetylhydrazine
acetic acid, 2-acetylhydrazide
nsc 42939
hydrazine,2-diacetyl-
nsc42939
1,2-diacetylhydrazine
nsc-42939
n,n'-diacetylhydrazine
diacetyl hydrazine
einecs 221-576-1
sym-diacetylhydrazine
diacetylahydrazine
hydrazine, 1,2-diacetyl-
diacetylhydrazine
n'-acetylacetohydrazide
3148-73-0
1,2-diacetylhydrazine, 98%
D2796
NCGC00248525-01
n'-acetyl-acetic acid hydrazide
NCGC00257653-01
dtxsid7020390 ,
cas-3148-73-0
dtxcid10390
tox21_200099
A820875
unii-ymr3zf0q4m
ymr3zf0q4m ,
ec 221-576-1
FT-0606330
AKOS015900792
SCHEMBL606948
CHEMBL3091852
chebi:80616 ,
diacetylhydrazide
n'-acetylacetohydrazide #
mfcd00008673
AS-57968
J-018442
Q27149664
D87230
SCHEMBL23224226
SB86069
n,n inverted exclamation mark -diacetylhydrazine
SY048493

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" This pharmacokinetic analysis, however, also shows that the apparent plasma half-life of acetylhydrazine is about five times longer than the plasma half-life of isoniazid, and thus repeated doses of isoniazid should lead to an accumulation of acetylhydrazine in the slowest acetylators in which the plasma half-life of acetylhydrazine is 20-plus hr."( Pharmacokinetics of the toxic hydrazino metabolites formed from isoniazid in humans.
Lauterburg, BH; Mitchell, JR; Smith, CV; Todd, EL, 1985
)
0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
carbohydrazideA hydrazide consisting of hydrazine carrying one or more carboacyl groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1059231Antitubercular activity against Mycobacterium tuberculosis2013European journal of medicinal chemistry, , Volume: 70Comparison of Multiple Linear Regressions and Neural Networks based QSAR models for the design of new antitubercular compounds.
AID1059234Lipophilicity, log P of the compound2013European journal of medicinal chemistry, , Volume: 70Comparison of Multiple Linear Regressions and Neural Networks based QSAR models for the design of new antitubercular compounds.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (62.50)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.19

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.19 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.19)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
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