Compounds > n-methyl-n-nitroso-(4-methylphenyl)methylamine
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n-methyl-n-nitroso-(4-methylphenyl)methylamine

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Description

N-methyl-N-nitroso-(4-methylphenyl)methylamine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID44161
CHEMBL ID107002
MeSH IDM0095601

Synonyms (15)

Synonym
ccris 2569
brn 5507971
n-nitroso-n-(4-methylbenzyl)methylamine
n-methyl-n-nitroso-(4-methylphenyl)methylamine
benzylamine, n,p-dimethyl-n-nitroso-
n-nitroso-n-(4-methylbenzyl)-methylamin [german]
CHEMBL107002
n-methyl-n-[(4-methylphenyl)methyl]nitrous amide
n-nitroso-n-(4-methylbenzyl)-methylamin
62783-50-0
n-methyl-n-(4-methylbenzyl)nitrosamine
DTXSID40211855
benzenemethanamine, n,4-dimethyl-n-nitroso-
EFQ7KJ4JCS
n,4-dimethyl-n-nitrosobenzenemethanamine

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" The dose-response data were subjected to a multiple linear regression equation calculated in a stepwise manner, which found that the differences in mutagenicities could be explained primarily by differences in the three-bond path molecular connectivity index, with smaller contributions from sigma and pi."( Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
Andrews, AW; Guo, SM; Singer, GM, 1986)		0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (35)

Assay IDTitleYearJournalArticle
AID87264compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells at dose of 50 ug1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID202950Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 1 ug1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Mutagenicity and chemistry of N-nitroso-N-(p-substituted-benzyl)methylamines.
AID87251compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells at dose of 250 ug1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID202955Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 500 ug1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Mutagenicity and chemistry of N-nitroso-N-(p-substituted-benzyl)methylamines.
AID202954Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 25 ug1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Mutagenicity and chemistry of N-nitroso-N-(p-substituted-benzyl)methylamines.
AID202949Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 10 ug1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Mutagenicity and chemistry of N-nitroso-N-(p-substituted-benzyl)methylamines.
AID87260compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells at dose of 2.5 ug1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID87250compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells at dose of 2.5 ug1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID87122Mutagenicity against Salmonella tester strain TA 1535 without hamster S9 mix (3 mg/plate) in cells.1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID87263compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells at dose of 500 ug1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID87249compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells at dose of 1 ug1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID87253compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells at dose of 500 ug1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID87255compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells at dose of 5 ug1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID87252compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells at dose of 25 ug1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID202948Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 100 ug1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Mutagenicity and chemistry of N-nitroso-N-(p-substituted-benzyl)methylamines.
AID202958Activity expressed as no. of revertants per plate in strain TA1535 with hamster S9 cells (3 mg/plate)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Mutagenicity and chemistry of N-nitroso-N-(p-substituted-benzyl)methylamines.
AID202956Activity expressed as no. of revertants per plate in Salmonella Typhimurium TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 50 ug1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Mutagenicity and chemistry of N-nitroso-N-(p-substituted-benzyl)methylamines.
AID202951Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 2.5 ug1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Mutagenicity and chemistry of N-nitroso-N-(p-substituted-benzyl)methylamines.
AID87265compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells at dose of 5 ug1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID87120compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells. Activity expressed as no. of cells1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID87256compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells at dose of 1000 ug1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID202957Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 5 ug1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Mutagenicity and chemistry of N-nitroso-N-(p-substituted-benzyl)methylamines.
AID87261compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells at dose of 250 ug1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID87121compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells.1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID202953Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 250 ug1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Mutagenicity and chemistry of N-nitroso-N-(p-substituted-benzyl)methylamines.
AID87119compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells.1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID202947Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 1000 ug1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Mutagenicity and chemistry of N-nitroso-N-(p-substituted-benzyl)methylamines.
AID87248compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells at dose of 10 ug1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID87257compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells at dose of 100 ug1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID87254compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells at dose of 50 ug1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID87124compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells at dose of 100 ug1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID87123compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells at dose of 1000 ug1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID87262compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells at dose of 25 ug1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID87258compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells at dose of 10 ug1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
AID87259compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells at dose of 1 ug1986Journal of medicinal chemistry, Jan, Volume: 29, Issue:1
Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: possible implications for carcinogenicity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (80.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.53 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-nitroquinoline-1-oxide
4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.		2.0610C-nitro compound;
quinoline N-oxide		carcinogenic agent
dimethylnitrosamine
Dimethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents.		2.6730nitrosaminegeroprotector;
mutagen
nitrosobenzylmethylamine
nitrosobenzylmethylamine: structure		2.6530
ConditionIndicatedRelationship StrengthStudiesTrials
Disease Exacerbation
[description not available]		02.0610
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.0610
Cancer of Esophagus
[description not available]		02.3920
Innate Inflammatory Response
[description not available]		02.0610
Cancer of Stomach
[description not available]		02.0610
Cancer of the Tongue
[description not available]		02.0610
Esophageal Neoplasms
Tumors or cancer of the ESOPHAGUS.		02.3920
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0610
Stomach Neoplasms
Tumors or cancer of the STOMACH.		02.0610
Tongue Neoplasms
Tumors or cancer of the TONGUE.		02.0610
Experimental Neoplasms
[description not available]		01.9610