Compounds > n-decyl phosphoric acid
Page last updated: 2024-11-06

n-decyl phosphoric acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

n-Decyl phosphoric acid, also known as decylphosphonic acid, is a long-chain alkylphosphonic acid. It is a white solid with a molecular weight of 264.3 g/mol and has a melting point of 62-64 °C. It is synthesized by reacting n-decyl alcohol with phosphorus trichloride and water. n-Decyl phosphoric acid is a key component in the formation of ionic liquids, which are salts that are liquid at room temperature. These ionic liquids have a wide range of applications, including catalysis, electrochemistry, and separation processes. n-Decyl phosphoric acid is also used as a surfactant, an emulsifier, and a corrosion inhibitor. It is studied due to its unique properties, such as its ability to form stable ionic liquids and its potential applications in various fields.'

n-decyl phosphoric acid: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID62532
CHEMBL ID361255
SCHEMBL ID597742
MeSH IDM0057119

Synonyms (23)

Synonym
phosphoric acid, monodecyl ester
3921-30-0
n-decyl phosphoric acid
phosphoric acid, decyl ester
decyl dihydrogen phosphate
CHEMBL361255 ,
phosphoric acid monodecyl ester
bdbm50170850
einecs 223-491-5
unii-js9np12y1y
js9np12y1y ,
ai3-17201
decyl phosphate
fap10
decanol phosphate
fap-10
gtpl4030
SCHEMBL597742
n-decyl phosphate
monodecyl phosphate
DTXSID1042289
Q27077007
SY299104
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Lysophosphatidic acid receptor 3Homo sapiens (human)IC50 (µMol)0.38400.08500.56481.6000AID248443
Lysophosphatidic acid receptor 3Homo sapiens (human)Ki0.12100.03900.43961.6880AID239112
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Lysophosphatidic acid receptor 2Homo sapiens (human)EC50 (µMol)1.80000.00200.31161.8000AID246337
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (13)

Processvia Protein(s)Taxonomy
G protein-coupled receptor signaling pathwayLysophosphatidic acid receptor 2Homo sapiens (human)
activation of phospholipase C activityLysophosphatidic acid receptor 2Homo sapiens (human)
positive regulation of cytosolic calcium ion concentrationLysophosphatidic acid receptor 2Homo sapiens (human)
positive regulation of Rho protein signal transductionLysophosphatidic acid receptor 2Homo sapiens (human)
positive regulation of MAPK cascadeLysophosphatidic acid receptor 2Homo sapiens (human)
regulation of metabolic processLysophosphatidic acid receptor 2Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathwayLysophosphatidic acid receptor 2Homo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerLysophosphatidic acid receptor 3Homo sapiens (human)
positive regulation of cytosolic calcium ion concentrationLysophosphatidic acid receptor 3Homo sapiens (human)
chemical synaptic transmissionLysophosphatidic acid receptor 3Homo sapiens (human)
gene expressionLysophosphatidic acid receptor 3Homo sapiens (human)
bleb assemblyLysophosphatidic acid receptor 3Homo sapiens (human)
positive regulation of MAPK cascadeLysophosphatidic acid receptor 3Homo sapiens (human)
collateral sproutingLysophosphatidic acid receptor 3Homo sapiens (human)
positive regulation of collateral sproutingLysophosphatidic acid receptor 3Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathwayLysophosphatidic acid receptor 3Homo sapiens (human)
regulation of metabolic processLysophosphatidic acid receptor 3Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Processvia Protein(s)Taxonomy
protein bindingLysophosphatidic acid receptor 2Homo sapiens (human)
lipid bindingLysophosphatidic acid receptor 2Homo sapiens (human)
PDZ domain bindingLysophosphatidic acid receptor 2Homo sapiens (human)
lysophosphatidic acid receptor activityLysophosphatidic acid receptor 2Homo sapiens (human)
G protein-coupled receptor activityLysophosphatidic acid receptor 2Homo sapiens (human)
protein bindingLysophosphatidic acid receptor 3Homo sapiens (human)
lipid bindingLysophosphatidic acid receptor 3Homo sapiens (human)
lysophosphatidic acid receptor activityLysophosphatidic acid receptor 3Homo sapiens (human)
G protein-coupled receptor activityLysophosphatidic acid receptor 3Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (8)

Processvia Protein(s)Taxonomy
endocytic vesicleLysophosphatidic acid receptor 2Homo sapiens (human)
plasma membraneLysophosphatidic acid receptor 2Homo sapiens (human)
cell surfaceLysophosphatidic acid receptor 2Homo sapiens (human)
presynaptic active zone membraneLysophosphatidic acid receptor 2Homo sapiens (human)
glutamatergic synapseLysophosphatidic acid receptor 2Homo sapiens (human)
plasma membraneLysophosphatidic acid receptor 2Homo sapiens (human)
cytoplasmLysophosphatidic acid receptor 2Homo sapiens (human)
plasma membraneLysophosphatidic acid receptor 3Homo sapiens (human)
axonLysophosphatidic acid receptor 3Homo sapiens (human)
synapseLysophosphatidic acid receptor 3Homo sapiens (human)
plasma membraneLysophosphatidic acid receptor 3Homo sapiens (human)
cytoplasmLysophosphatidic acid receptor 3Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID239112Binding affinity for Lysophosphatidic acid receptor 3 expressed in RH7777 rat hepatoma cells2005Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.
AID248443Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA3 receptor2005Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.
AID248071Inhibitory concentration against LPA expressed in PC-3 cells; Not determined2005Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.
AID246337Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor2005Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.
AID248649Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor; No effect2005Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.
AID248650Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor; No effect2005Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.
AID246420Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA3 receptor; No effect2005Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.
AID246418Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor; No effect2005Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.
AID247117Maximal efficacy against LPA2 receptor expressed in RH7777 rat hepatoma cells2005Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.
AID246335Inhibition of LPA-induced calcium transients in PC-3 cells; Not determined2005Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.
AID1346102Human LPA2 receptor (Lysophospholipid (LPA) receptors)2003Molecular pharmacology, May, Volume: 63, Issue:5
Fatty alcohol phosphates are subtype-selective agonists and antagonists of lysophosphatidic acid receptors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.53 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
erythrosine
Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.		2.110
1-hexanol
1-hexanol: RN given refers to parent cpd. hexanol : A fatty alcohol consisting of a hydroxy function at any position of an unbranched saturated chain of six carbon atoms.. hexan-1-ol : A primary alcohol that is hexane substituted by a hydroxy group at position 1.		2.0610hexanol;
primary alcohol		alarm pheromone;
antibacterial agent;
fragrance;
plant metabolite
dodecyltrimethylammonium
dodecyltrimethylammonium: used to determine thermal stability of DNA; RN given refers to parent cpd. dodecyltrimethylammonium ion : A quarternary ammonium cation having one dodecyl and three methyl substituents around the central nitrogen.		1.9510quaternary ammonium ion
6-carboxyfluorescein
6-carboxyfluorescein: originally sold as 6-carboxyfluorescein, but commercial product is a mixture of two isomers; correct name is 5(6)-carboxyfluorescein		2.110monocarboxylic acid
diacylglycerol pyrophosphate
1,2-dioctanoyl-sn-glycerol 3-diphosphate : A 1,2-diacyl-sn-glycerol 3-diphosphate in which both of the phosphatidyl acyl groups are specified as octanoyl.		2.02101,2-diacyl-sn-glycerol 3-diphosphate;
octanoate ester
ki16425
3-[({4-[4-({[1-(2-chlorophenyl)ethoxy]carbonyl}amino)-3-methyl-1,2-oxazol-5-yl]phenyl}methyl)sulfanyl]propanoic acid : A member of the class of isoxazoles that is the carbamate ester obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)ethyl hydrogen carbonate with the amino group of 3-({[4-(4-amino-3-methyl-1,2-oxazol-5-yl)phenyl]methyl}sulfanyl)propanoic acid.		2.0210carbamate ester;
isoxazoles;
monocarboxylic acid;
monochlorobenzenes;
organic sulfide
ConditionIndicatedRelationship StrengthStudiesTrials