Compounds > n-bromophthalimide
Page last updated: 2024-12-06

n-bromophthalimide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

N-Bromophthalimide (NBP) is a brominating reagent used in organic synthesis. It is a white solid that is stable in air and light. NBP is typically prepared by the reaction of phthalimide with bromine in the presence of a base, such as sodium hydroxide or potassium hydroxide. NBP is a versatile reagent that can be used to brominate a wide variety of substrates, including alkanes, alkenes, alkynes, and aromatic compounds. The bromination reaction is typically carried out in a solvent such as dichloromethane or chloroform. NBP is an effective brominating agent because it is a good electrophile and because it can be easily prepared and handled. NBP has been studied for its use in organic synthesis, particularly for its ability to selectively brominate organic compounds. It is widely used in the pharmaceutical industry for the synthesis of various pharmaceuticals. Its importance lies in its ability to introduce bromine atoms into organic molecules, which can modify the chemical and physical properties of the molecule. NBP is also used in the synthesis of other useful reagents, such as NBS (N-bromosuccinimide). '

Cross-References

ID SourceID
PubMed CID75542
SCHEMBL ID1771
MeSH IDM0158664

Synonyms (29)

Synonym
8ec67s8pww ,
nsc 3525
ai3-18212
einecs 219-467-9
1h-isoindole-1,3(2h)-dione, 2-bromo-
unii-8ec67s8pww
AKOS015836194
2439-85-2
nsc3525
nsc-3525
n-bromophthalimide
n-bromophthalimide, 95%
B1697 ,
2-bromoisoindole-1,3-dione
2-bromo-1h-isoindole-1,3(2h)-dione
A817278
FT-0634283
STL268906
2-bromoisoindoline-1,3-dione
SCHEMBL1771
MARXMDRWROUXMD-UHFFFAOYSA-N
n-bromophtalimide
n-bromo phthalimide
mfcd00005888
DTXSID70179136
J-015498
O12021
CS-W013032
SY048359

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
"A titrimetric method is described for the determination of three acetylenic hypnotics, namely ethchlorvynol, ethinamate, and methylpentynol carbamate, in bulk and in dosage forms."( Titrimetric determination of acetylenic hyponotics using organic brominating agents.
Belal, F; el-Brashy, A; Rizk, M; Walash, MI, 1988)		0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (37.50)18.7374
1990's1 (12.50)18.2507
2000's1 (12.50)29.6817
2010's3 (37.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.29

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.29 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.84 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.29)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbamates
[no description available]		1.9710amino-acid anion
4-aminobenzoic acid
4-Aminobenzoic Acid: An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.. 4-ammoniobenzoate : A zwitterion obtained by transfer of a proton from the carboxy to the amino group of 4-aminobenzoic acid.. 4-aminobenzoic acid : An aminobenzoic acid in which the amino group is para to the carboxy group.		1.9710aminobenzoic acid;
aromatic amino-acid zwitterion		allergen;
Escherichia coli metabolite;
plant metabolite
chlorpromazine
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.. chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.		1.9810organochlorine compound;
phenothiazines;
tertiary amine		anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug
ethinamate
ethinamate: short duration hypnotic with fast onset & relatively low toxicity; may cause dependence; minor descriptor (76-85); on-line & Index Medicus search CARBAMATES (76-85). ethinamate : A carbamate ester that is the 1-vinylcyclohexyl ester of carbamic acid. A short-acting sedative-hypnotic, it was formerly used to treat insomnia.		1.9710carbamate ester;
terminal acetylenic compound		sedative
guanidine
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.. guanidine : An aminocarboxamidine, the parent compound of the guanidines.		2.0710carboxamidine;
guanidines;
one-carbon compound
isoniazid
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).		1.9810carbohydrazideantitubercular agent;
drug allergen
saccharin
Saccharin: Flavoring agent and non-nutritive sweetener.. saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.		2.37201,2-benzisothiazole;
N-sulfonylcarboxamide		environmental contaminant;
sweetening agent;
xenobiotic
n-pentanol
n-pentanol: RN given refers to parent cpd. pentan-1-ol : A short-chain primary fatty alcohol that is pentane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It has been isolated from Melicope ptelefolia.		1.9710pentanol;
short-chain primary fatty alcohol		human metabolite;
plant metabolite
1,3-dibromo-5,5-dimethylhydantoin
[no description available]		1.9710
methylpentynol
methylpentynol: structure		1.9710ynone
phthalimide
phthalimide: RN given refers to parent cpd. phthalimide : A dicarboximide that is 2,3-dihydro-1H-isoindole substituted by oxo groups at positions 1 and 3.		7.0210phthalimides
hydantoins
Hydantoins: Compounds based on imidazolidine dione. Some derivatives are ANTICONVULSANTS.. imidazolidine-2,4-dione : An imidazolidinone with oxo groups at position 2 and 4.		1.9710imidazolidine-2,4-dione
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.0710glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
bromine
Bromine: A halogen with the atomic symbol Br, atomic number 35, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.		2.0710diatomic bromine
bromosuccinimide
Bromosuccinimide: A brominating agent that replaces hydrogen atoms in benzylic or allylic positions. It is used in the oxidation of secondary alcohols to ketones and in controlled low-energy brominations. (From Miall's Dictionary of Chemistry, 5th ed; Hawley's Condensed Chemical Dictionary, 12th ed,).		1.9710dicarboximide;
organobromine compound;
pyrrolidinone		reagent
ethchlorvynol
Ethchlorvynol: A sedative and hypnotic that has been used in the short-term management of INSOMNIA. Its use has been superseded by other drugs.. ethchlorvynol : Propargyl alcohol in which the methylene hydrogens are substituted by ethyl and 2-chlorovinyl groups. A hypnotic and sedative, it is used for treatment of insomnia in some cases where an intolerance or allergy to more commonly used drugs exists.		1.9710
ConditionIndicatedRelationship StrengthStudiesTrials