n-acryloyl-tris(hydroxymethyl)aminomethane profile

n-Acryloyl-tris(hydroxymethyl)aminomethane (A-Tris) is a synthetic monomer that is used in the preparation of hydrogels. It is a derivative of tris(hydroxymethyl)aminomethane (Tris), a common buffering agent in biological research. A-Tris can be synthesized via a reaction between Tris and acryloyl chloride. The acryloyl group makes A-Tris a reactive monomer that can polymerize via free radical polymerization, forming hydrogels with a variety of properties. A-Tris hydrogels are often used in biomedical applications, such as drug delivery, tissue engineering, and wound healing. They are biocompatible, biodegradable, and have good mechanical properties. The ability to control the properties of A-Tris hydrogels by varying the polymerization conditions, such as the concentration of monomers, crosslinkers, and initiators, makes them a versatile material for a range of applications. Research into A-Tris hydrogels focuses on improving their properties and expanding their applications in biomedicine and other fields.'

N-acryloyl-tris(hydroxymethyl)aminomethane: structure: CH2=CH-CO-NH-C(CH2OH)3 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	83788
SCHEMBL ID	105869
MeSH ID	M0151727

Synonym
n-acryloyltris(hydroxymethyl)aminomethane
n-[tris(hydroxymethyl)methyl]acrylamide, contains <=7% kcl, 93%
tris-acrylamide
13880-05-2
n-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]prop-2-enamide
n-[tris(hydroxymethyl)methyl]acrylamide
einecs 237-645-4
r8vgy8cvf2 ,
tris(hydroxymethyl)acrylaminomethane
unii-r8vgy8cvf2
n-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)acrylamide
n-acryloyl-tris(hydroxymethyl)aminomethane
n-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide
FT-0636974
AKOS015900619
SCHEMBL105869
2-propenamide, n-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)-
DTXSID60160790
mfcd00081045
J-007179
n-[tris(hydroxymethyl)methyl]-acrylamide
STR02781
n-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)-2-propenamide
C93420
2-propenamide, n-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-
30347-69-4
CS-0158040

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (12.50)	18.7374
1990's	1 (12.50)	18.2507
2000's	5 (62.50)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (12.50)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	1 (9.09%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (90.91%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
citric acid, anhydrous Citric Acid: A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.. citric acid : A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.	2.03	1	tricarboxylic acid	antimicrobial agent; chelator; food acidity regulator; fundamental metabolite
chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion.	2.03	1	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	2.01	1	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
mitomycin Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.	2.01	1	mitomycin	alkylating agent; antineoplastic agent
cytarabine [no description available]	2.01	1	beta-D-arabinoside; monosaccharide derivative; pyrimidine nucleoside	antimetabolite; antineoplastic agent; antiviral agent; immunosuppressive agent
trehalose alpha,alpha-trehalose : A trehalose in which both glucose residues have alpha-configuration at the anomeric carbon.	2.03	1	trehalose	Escherichia coli metabolite; geroprotector; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
arginyl-glycyl-aspartic acid arginyl-glycyl-aspartic acid: amino acid sequence of basic unit of widespread cellular recognition system	2.01	1	oligopeptide
biotin vitamin B7 : Any member of a group of vitamers that belong to the chemical structural class called biotins that exhibit biological activity against vitamin B7 deficiency. Vitamin B7 deficiency is very rare in individuals who take a normal balanced diet. Foods rich in biotin are egg yolk, liver, cereals, vegetables (spinach, mushrooms) and rice. Symptoms associated with vitamin B7 deficiency include thinning hair, scaly skin rashes around eyes, nose and mouth, and brittle nails. The vitamers include biotin and its ionized and salt forms.	2.25	1	biotins; vitamin B7	coenzyme; cofactor; Escherichia coli metabolite; fundamental metabolite; human metabolite; mouse metabolite; nutraceutical; prosthetic group; Saccharomyces cerevisiae metabolite
carboplatin [no description available]	2.01	1
pirarubicin [no description available]	2.01	1	anthracycline
sepharose agarose : A linear polysaccharide made up from alternating D-galactose and 3,6-anhydro-alpha-L-galactopyranose residues joined by alpha-(1->3)- and beta-(1->4)-linkages.	1.98	1

Condition	Relationship Strength	Studies
Angiogenesis, Pathologic [description not available]	2.01	1
Anoxemia [description not available]	2.02	1
Hepatocellular Carcinoma [description not available]	2.02	1
Pulmonary Hypertension [description not available]	2.02	1
Cancer of Liver [description not available]	2.02	1
Hypoxia Sub-optimal OXYGEN levels in the ambient air of living organisms.	2.02	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.02	1
Hypertension, Pulmonary Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.	2.02	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.02	1

n-acryloyl-tris(hydroxymethyl)aminomethane

Description

Cross-References

Synonyms (27)

Research

Studies (8)

Market Indicators

Research Demand Index: 12.41

Study Types