Compounds > n,2,6-trichloro-4-benzoquinone imine
Page last updated: 2024-12-05

n,2,6-trichloro-4-benzoquinone imine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N,2,6-trichloro-4-benzoquinone imine: universal thin-layer chromatographic visualization reagent [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID7556
CHEMBL ID3276931
SCHEMBL ID478999
MeSH IDM0055789

Synonyms (69)

Synonym
2,6-dichloroquinone-4-chloroimide
gibbs reagent
n-2,6-trichloro-p-benzoquinonimine
n-2,6-trichloro-p-benzoquinone imine
2,6-dichlorobenzoquinone chloroimide
2, 2,6-dichloro-4-(chloroimino)-
2,6-dichloro-4-n-chloroquinonimine
2,6-dichloroquinone chloroimide
p-benzoquinone imine,2,6-trichloro-
2,6-dichloroquinonechloroimine
2, 4-chloroimino-2,6-dichloro-
n,6-trichlorobenzoquinone imine
wln: l6v dyj bg dung fg
n,6-trichloro-p-benzoquinonimine
2,6-dichloroquinone-4-chloroimine
101-38-2
nsc6293
nsc-6293
2,6-dichloro-4-(chloroimino)-2,5-cyclohexadien-1-one
einecs 202-937-2
nsc 6293
n,2,6-trichloro-4-benzoquinone imine
n,2,6-trichlorobenzoquinone imine
n,2,6-trichloro-p-benzoquinonimine
4-chloroimino-2,6-dichloro-2,5-cyclohexadiene-1-one
n,2,6-trichloro-p-benzoquinone imine
ai3-52333
brn 2364249
2,5-cyclohexadien-1-one, 4-chloroimino-2,6-dichloro-
2,6-dichloro-4-(chloroimino)cyclohexa-2,5-dienone
p-benzoquinone imine, n,2,6-trichloro-
2,5-cyclohexadien-1-one, 2,6-dichloro-4-(chloroimino)-
2,6-dichloro-1,4-quinone-4-chlorimide
2,6-dichloro-4-chloroiminocyclohexa-2,5-dien-1-one
inchi=1/c6h2cl3no/c7-4-1-3(10-9)2-5(8)6(4)11/h1-2h
yhumthwqgwpjoq-uhfffaoysa-
n,2,6-trichloro-p-benzoquinone monoimine
T0397
n,2,6-trichloroquinoneimine
A800380
3-07-00-03377 (beilstein handbook reference)
unii-y19a13rzo0
y19a13rzo0 ,
FT-0610633
AKOS015901257
gibbs reagent [mi]
n,2,6-trichloro-p-quinoneimine
CHEMBL3276931
DTXSID2059229
SCHEMBL478999
J-610063
2,6-dichloroquinone-4-chlorimide
YHUMTHWQGWPJOQ-UHFFFAOYSA-N
gibbs' reagent
2,6-dichloro-4-(chloroimino)-2,5-cyclohexadien-1-one #
2,6-dichloro-p-benzoquinone-4-chlorimine
W-108918
mfcd00001611
2,6-dichloroquinone-4-chloroimide, for spectrophotometric det. of vitamin b6, >=99.0%
2,6-dichloroquinone-4-chloroimide, 99.0%
(s)-benzyl?1-chloropropan-2-ylcarbamate
Q209277
FS-4501
D88188
2,6-dichloro-4-(chloroimino)cyclohexa-2,5-dien-1-one
SY048612
HY-W105135
CS-0157777
PD197261

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" The suggested procedures could be used for the determination of mequitazine, both in pure and dosage forms, as well as in the presence of its degradate."( Stability indicating methods for assay of mequitazine in presence of its degradate.
Badawey, AM; El Khateeb, SZ; El-Ragehy, NA, 2002)		0.31
" The proposed methods were validated according to ICH guidelines and were successfully applied for the determination of VN and NF in their tablet dosage forms."( Application of π acceptors to the spectrophotometric and spectrofluorimetric determination of vincamine and naftidrofuryl oxalate in their pharmaceutical preparations.
Badr El-Dien, MM; Elbrashy, AM; Ibrahim, FA; Nasr, JJM, 2017)		0.46
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID1148231Half life of the compound in water at pH 7 at 25 degC by spectrophotometry1978Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
Nitrogen analogues of 1,4-benzoquinones. Activities against the ascitic sarcoma 180 of mice.
AID1148235Antitumor activity against mouse Sarcoma 180 cells allografted in Swiss mouse assessed as survival at 10 mg/kg, ip three doses were given at 24 hrs interval starting 24 hrs after allograft injection measured after 5 days1978Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
Nitrogen analogues of 1,4-benzoquinones. Activities against the ascitic sarcoma 180 of mice.
AID1148260Antitumor activity against mouse Sarcoma 180 cells allografted in Swiss mouse assessed as cure at 10 mg/kg, ip three doses were given at 24 hrs interval starting 24 hrs after allograft injection measured after 60 days1978Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
Nitrogen analogues of 1,4-benzoquinones. Activities against the ascitic sarcoma 180 of mice.
AID1148285Antitumor activity against mouse Sarcoma 180 cells allografted in Swiss mouse at 10 mg/kg, ip three doses were given at 24 hrs interval starting 24 hrs after allograft injection relative to control1978Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
Nitrogen analogues of 1,4-benzoquinones. Activities against the ascitic sarcoma 180 of mice.
AID1148270Antitumor activity against mouse Sarcoma 180 cells allografted in Swiss mouse assessed as survival time at 10 mg/kg, ip three doses were given at 24 hrs interval starting 24 hrs after allograft injection relative to control1978Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
Nitrogen analogues of 1,4-benzoquinones. Activities against the ascitic sarcoma 180 of mice.
AID1148228Antitumor activity against mouse Sarcoma 180 cells allografted in Swiss mouse assessed as weight gain at 10 mg/kg, ip three doses were given at 24 hrs interval starting 24 hrs after allograft injection measured after 3 days relative to control1978Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
Nitrogen analogues of 1,4-benzoquinones. Activities against the ascitic sarcoma 180 of mice.
AID1148298Redox potential of the compound in octanol-water solution1978Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
Nitrogen analogues of 1,4-benzoquinones. Activities against the ascitic sarcoma 180 of mice.
AID1148232Acute toxicity in single ip dosed Swiss mouse assessed as death up to 5 days1978Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
Nitrogen analogues of 1,4-benzoquinones. Activities against the ascitic sarcoma 180 of mice.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (41.18)18.7374
1990's2 (11.76)18.2507
2000's6 (35.29)29.6817
2010's2 (11.76)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.37

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.37 (24.57)
Research Supply Index3.00 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.37)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other19 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
guaiacol
Guaiacol: An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747). methylcatechol : Any member of the class of catechols carrying one or more methyl substituents.. guaiacol : A monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position.		1.9510guaiacolsdisinfectant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
expectorant;
plant metabolite
phenol
[no description available]		1.9510phenolsantiseptic drug;
disinfectant;
human xenobiotic metabolite;
mouse metabolite
uric acid
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.. uric acid : An oxopurine that is the final oxidation product of purine metabolism.. 6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.. 7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.		1.9710uric acidEscherichia coli metabolite;
human metabolite;
mouse metabolite
oxyquinoline
Oxyquinoline: An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.. quinolin-8-ol : A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.		1.9610monohydroxyquinolineantibacterial agent;
antifungal agrochemical;
antiseptic drug;
iron chelator
albuterol
Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.. albuterol : A member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).		2.0110phenols;
phenylethanolamines;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
environmental contaminant;
xenobiotic
ampyrone
Ampyrone: A metabolite of AMINOPYRINE with analgesic and anti-inflammatory properties. It is used as a reagent for biochemical reactions producing peroxides or phenols. Ampyrone stimulates LIVER MICROSOMES and is also used to measure extracellular water.		1.9810primary amino compound;
pyrazolone		antipyretic;
antirheumatic drug;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
marine xenobiotic metabolite;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
peripheral nervous system drug
mequitazine
mequitazine: RN given refers to parent cpd without isomeric designation; structure		2.0110phenothiazines
nafronyl
Nafronyl: A drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1310) It may also be an antagonist at 5HT-2 serotonin receptors.		2.1510naphthalenes
propranolol
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.. propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.		2.0410naphthalenes;
propanolamine;
secondary amine		anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic
chloroform
Chloroform: A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.. chloroform : A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines.		2.0310chloromethanes;
one-carbon compound		carcinogenic agent;
central nervous system drug;
inhalation anaesthetic;
non-polar solvent;
refrigerant
dichlorodicyanobenzoquinone
dichlorodicyanobenzoquinone: request from searcher		2.1510
3,5-dinitrobenzoic acid
3,5-dinitrobenzoic acid : A member of the class of benzoic acids that is benzoic acid in which the hydrogens at positions 3 and 5 are replaced by nitro groups.		2.0310benzoic acids;
C-nitro compound
4-nitrosophenol
4-nitrosophenol: RN given refers to unlabeled parent cpd		1.9510
4-toluidine
4-toluidine: RN given refers to parent cpd. p-toluidine : An aminotoluene in which the amino substituent is para to the methyl group.		2.0310aminotoluene
2-tolidine
2-tolidine: RN given refers to parent cpd; structure		2.0310biphenyls
mequinol
mequinol: depigmenting agent; RN given refers to parent cpd		1.9510methoxybenzenes;
phenols		metabolite
thiazoles
[no description available]		2.01101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
vincamine
Vincamine: A major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders.		2.1510alkaloid ester;
hemiaminal;
methyl ester;
organic heteropentacyclic compound;
vinca alkaloid		antihypertensive agent;
metabolite;
vasodilator agent
prenalterol
Prenalterol: A partial adrenergic agonist with functional beta 1-receptor specificity and inotropic effect. It is effective in the treatment of acute CARDIAC FAILURE, postmyocardial infarction low-output syndrome, SHOCK, and reducing ORTHOSTATIC HYPOTENSION in the SHY-RAGER SYNDROME.		1.9810aromatic ether
tetracyanoquinodimethane
tetracyanoquinodimethane: structure. tetracyanoquinodimethane : A quinodimethane that is p-quinodimethane in which the methylidene hydrogens are replaced by cyano groups.		2.4620alicyclic compound;
nitrile;
quinodimethane
indophenyl acetate
[no description available]		1.9510
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		210
methimazole
Methimazole: A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme.. methimazole : A member of the class of imidazoles that it imidazole-2-thione in which a methyl group replaces the hydrogen which is attached to a nitrogen.		1.96101,3-dihydroimidazole-2-thionesantithyroid drug
thiosemicarbazide
thiosemicarbazide: glutamate decarboxylase antagonist; structure given in first source. hydrazinecarbothioamide : A member of the class of thioureas that is thiourea in which a hydrogen of one of the amino groups is replaced by an amino group.		2.2110hydrazines;
thiocarboxamide;
thioureas
lead
Lead: A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.		2.2110carbon group element atom;
elemental lead;
metal atom		neurotoxin
3-methyl-2-benzothiazolone hydrazone
3-methyl-2-benzothiazolone hydrazone: RN given refers to parent cpd		2.0110
chitosan
[no description available]		2.2110
chiniofon
Hydroxyquinolines: The 8-hydroxy derivatives inhibit various enzymes and their halogenated derivatives, though neurotoxic, are used as topical anti-infective agents, among other uses.		1.9610
ConditionIndicatedRelationship StrengthStudiesTrials
Sarcoma 180
An experimental sarcoma of mice.		01.9510