Compounds > n-(gamma-maleimidobutyryloxy)succinimide
Page last updated: 2024-11-07

n-(gamma-maleimidobutyryloxy)succinimide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID133440
SCHEMBL ID105903
MeSH IDM0100473

Synonyms (40)

Synonym
1h-pyrrole-2,5-dione, 1-(4-((2,5-dioxo-1-pyrrolidinyl)oxy)-4-oxobutyl)-
n-(gamma-maleimidobutyryloxy)succinimide
gmbs
80307-12-6
4-maleimidobutyric acid n-succinimidyl ester
n-succinimidyl 4-maleimidobutyrate
n-(4-maleimidobutyryloxy)succinimide
(2,5-dioxopyrrolidin-1-yl) 4-(2,5-dioxopyrrol-1-yl)butanoate
4-maleimidobutyric acid n-hydroxysuccinimide ester
FT-0604086
AKOS015894342
SCHEMBL105903
DTXSID60230240
PVGATNRYUYNBHO-UHFFFAOYSA-N
2,5-dioxopyrrolidin-1-yl 4-(2,5-dioxo-2,5-dihydro-1h-pyrrol-1-yl)butanoate
butylethyldisulphide
mfcd00036817
4-maleimidobutyric acid n-hydroxysuccinimide ester, >=98.0% (hplc)
n-y-maleimidobutyryloxy succinimide ester
(gmbs);4-maleimidobutyric acid nhs
HY-W041994
gmbs crosslinker
succinimidyl 4-maleimidylbutyrate
n-(gamma-maleimidobutyryloxy) succinimidyl ester
1h-pyrrole-2,5-dione, 1-[4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4-oxobutyl]-
gamma-maleimidobutyric acid n-succinimidyl ester
Z7GNH9BK5Z
succinimidyl 4-(maleimido)butanoate
1h-pyrrole-1-butanoic acid, 2,5-dihydro-2,5-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester
n-succinimidyl 4-maleimidobutyrate [cross-linking reagent]
CS-W022734
AS-10474
AMY21536
EN300-105191
gmbs;2,5-dioxopyrrolidin-1-yl 4-(2,5-dioxo-2,5-dihydro-1h-pyrrol-1-yl)butanoate;gmbs
A864707
SY035046
4-maleimidobutyric acid-nhs(gmbs)
BP-31232
2,5-dioxopyrrolidin-1yl 4-(2,5-dioxo-2,5-dihydro-1h-pyrrol-1-yl)butanoate
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (18)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (16.67)18.7374
1990's5 (27.78)18.2507
2000's6 (33.33)29.6817
2010's2 (11.11)24.3611
2020's2 (11.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.79

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.79 (24.57)
Research Supply Index3.00 (2.92)
Research Growth Index4.78 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.79)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other19 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
phosphoserine
Phosphoserine: The phosphoric acid ester of serine.		2.0310non-proteinogenic alpha-amino acid;
O-phosphoamino acid;
serine derivative		human metabolite
n'-acetylspermine
N(1)-acetylspermine : An acetylspermine carrying an acetyl group at position N(1).		2.3920acetamides;
acetylspermine		human metabolite
spermine
[no description available]		7.6830polyazaalkane;
tetramine		antioxidant;
fundamental metabolite;
immunosuppressive agent
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.0710glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
gold
Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.		2.610copper group element atom;
elemental gold
daunorubicin
Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.. anthracycline : Anthracyclines are polyketides that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.. daunorubicin : A natural product found in Actinomadura roseola.		1.9610aminoglycoside antibiotic;
anthracycline;
p-quinones;
tetracenequinones		antineoplastic agent;
bacterial metabolite
3-(trimethoxysilyl)propylamine
3-(trimethoxysilyl)propylamine: reagent for making polymers; structure in first source		2.0110
arginyl-glycyl-aspartyl-serine
arginyl-glycyl-aspartyl-serine: corresponds to cell attachment site of fibronectin; located near carboxyl-terminal region of alpha-chain of fibrinogen; inhibits platelet aggregation & fibrinogen binding to activated platelets		2.3110
m-maleimidobenzoyl-n-hydroxysulfosuccinimide ester
[no description available]		2.0810
n',n''-diacetylspermine
N',N''-diacetylspermine: intermediate in polyamine catabolism		2.3920acetamides
n-(beta-(4-diazophenyl)ethyl)maleimide
N-(beta-(4-diazophenyl)ethyl)maleimide: used in developing enzyme immunoassay for neurotensin; structure given in first source		1.9710
ovalbumin
Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.		2.0110
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		2.0210cysteiniumfundamental metabolite
oligonucleotides
[no description available]		2.0210
lewis x antigen
Lewis X Antigen: A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, Lewis X antigen is a stage-specific embryonic antigen.		1.9710
ConditionIndicatedRelationship StrengthStudiesTrials
B-Cell Chronic Lymphocytic Leukemia
[description not available]		02.3110
Leukemia, Lymphocytic, Chronic, B-Cell
A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.		02.3110
Cardiovascular Stroke
[description not available]		02.0810
Myocardial Infarction
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).		02.0810
Malignant Melanoma
[description not available]		01.9810
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		01.9810
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)		01.9810
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.3920
Cancer of Lung
[description not available]		01.9710
Lung Neoplasms
Tumors or cancer of the LUNG.		01.9710