Page last updated: 2024-12-11

n-(aminocarbonyl)-2-ethyl-2-butenamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID5354486
SCHEMBL ID1641674
SCHEMBL ID1641676
MeSH IDM0200554

Synonyms (55)

Synonym
2-ethylcrotonylurea
nsc169502
1-(2-ethylcrotonoyl)urea
nsc69731
nsc69733
nsc-69733
nsc-69731
nsc11776
2884-67-5
nsc-11776
(.alpha.-ethylcrotonyl)carbamide
urea, (.alpha.-ethylcrotonoyl)-
crotonyl ureide, .alpha.-ethyl-
2-butenamide, n-(aminocarbonyl)-2-ethyl-
5982-97-8
wln: zvmvy2&u2
nsc163913
(.alpha.-ethylcrotonyl)urea
urea, (2-ethylcrotonoyl)-
(2-ethylcrotonoyl)urea
NCGC00160571-01
nsc 163913
n-(aminocarbonyl)-2-ethyl-2-butenamide
(alpha-ethylcrotonyl)carbamide
nsc 11776
crotonyl ureide, alpha-ethyl-
ma-117
einecs 227-794-3
urea, (alpha-ethylcrotonoyl)-
(alpha-ethylcrotonyl)urea
urea, (2-ethylcrotonoyl)-, trans-
trans-1-(2-ethylcrotonoyl)urea
2-ethyl-trans-crotonylurea
(e)-n-carbamoyl-2-ethylbut-2-enamide
cas-5982-97-8
dtxcid5028950
tox21_113550
AKOS024332395
unii-49876e91se
ectylurea, (e)-
49876e91se ,
smr002530295
MLS006010872
SCHEMBL1641674
SCHEMBL1641676
QCUPYFTWJOZAOB-HWKANZROSA-N
n-(2-ethyl-2-butenoyl)urea
urea, (2-ethylcrotonoyl)-, (e)-
2-butenamide, n-(aminocarbonyl)-2-ethyl-, (e)-
(2-ethyl-trans-crotonyl)urea
2-butenamide,n-(aminocarbonyl)-2-ethyl-, (e)-(9ci)
(e)-ectylurea
Q27259255
DTXSID901031174
[(2e)-2-ethylbut-2-enoyl]urea

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
estrogen nuclear receptor alphaHomo sapiens (human)Potency26.87020.000229.305416,493.5996AID743075; AID743079
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-199011 (68.75)18.7374
1990's2 (12.50)18.2507
2000's0 (0.00)29.6817
2010's1 (6.25)24.3611
2020's2 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.31

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.31 (24.57)
Research Supply Index2.83 (2.92)
Research Growth Index4.14 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.31)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]