N-(4-(2-chlorophenyl)-6,7-dimethyl-3-quinolyl)-N'-(2,4-difluorophenyl)urea: an acyl-CoA:cholesterol aceyltransferase inhibitor; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 125289 |
| CHEMBL ID | 64976 |
| SCHEMBL ID | 4100046 |
| MeSH ID | M0233654 |
| Synonym |
|---|
| bdbm50038923 |
| 1-[4-(2-chloro-phenyl)-6,7-dimethyl-quinolin-3-yl]-3-(2,4-difluoro-phenyl)-urea |
| cdqdu |
| CHEMBL64976 , |
| 1-[4-(2-chlorophenyl)-6,7-dimethylquinolin-3-yl]-3-(2,4-difluorophenyl)urea |
| n-(4-(2-chlorophenyl)-6,7-dimethyl-3-quinolinyl)-n'-(2,4-difluorophenyl)urea |
| tmp-153 |
| n-(4-(2-chlorophenyl)-6,7-dimethyl-3-quinolyl)-n'-(2,4-difluorophenyl)urea |
| 128831-46-9 |
| urea, n-(4-(2-chlorophenyl)-6,7-dimethyl-3-quinolinyl)-n'-(2,4-difluorophenyl)- |
| tmp 153 |
| SCHEMBL4100046 |
| DTXSID40155987 |
| J-005629 |
| 1-(4-(2-chlorophenyl)-6,7-dimethylquinolin-3-yl)-3-(2,4-difluorophenyl)urea |
| urea, n-[4-(2-chlorophenyl)-6,7-dimethyl-3-quinolinyl]-n'-(2,4-difluorophenyl)- |
| PD019995 |
| AKOS040755061 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " Here we report that three acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitors, TMP-153, FR179254 or YIC-C8-434, were more toxic to prion-infected neuronal cell lines (ScGT1 and ScN2a cells) than to their uninfected equivalents (GT1 and N2a cells)." | ( Cholesterol esterification reduces the neurotoxicity of prions. Bate, C; Tayebi, M; Williams, A, 2008) | 0.35 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Sterol O-acyltransferase 1 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 0.0058 | 0.0058 | 0.6626 | 6.0000 | AID31376 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 0.0058 | 0.0002 | 0.5521 | 10.0000 | AID31376 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID84844 | Effective dose to reduce the plasma cholesterol in hamsters | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13 | Novel acyl-CoA:cholesterol acyltransferase inhibitors. Synthesis and biological activity of 3-quinolylurea derivatives. |
| AID31376 | Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13 | Novel acyl-CoA:cholesterol acyltransferase inhibitors. Synthesis and biological activity of 3-quinolylurea derivatives. |
| AID87098 | Plamsa cholesterol leval was measured in hamsters at 0.0001% cholesterol diet as a dietary admixture | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13 | Novel acyl-CoA:cholesterol acyltransferase inhibitors. Synthesis and biological activity of 3-quinolylurea derivatives. |
| AID87100 | Plamsa cholesterol leval was measured in hamsters at 0.001% cholesterol diet as a dietary admixture | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13 | Novel acyl-CoA:cholesterol acyltransferase inhibitors. Synthesis and biological activity of 3-quinolylurea derivatives. |
| AID31519 | Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase at 10 e-6 M in rat microsomes | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13 | Novel acyl-CoA:cholesterol acyltransferase inhibitors. Synthesis and biological activity of 3-quinolylurea derivatives. |
| AID87099 | Plamsa cholesterol leval was measured in hamsters at 0.0003% cholesterol diet as a dietary admixture | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13 | Novel acyl-CoA:cholesterol acyltransferase inhibitors. Synthesis and biological activity of 3-quinolylurea derivatives. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.60) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||