n-(3-pyridylmethyl)pyrrolidine profile

N-(3-pyridylmethyl)pyrrolidine: nicotine antagonist; RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	67786
CHEMBL ID	148489
SCHEMBL ID	1538320
MeSH ID	M0188640

Synonym
nsc-628102
nsc628102
3-(pyrrolidin-1-ylmethyl)pyridine
3-(1-pyrrolidinylmethyl)pyridine
3-pyrrolidin-1-ylmethyl-pyridine
bdbm50138491
n-(3-pyridylmethyl)pyrrolidine
CHEMBL148489 ,
(3-pyridylmethyl)pyrrolidine
370-09-2
STK117679
pyridine, 3-(1-pyrrolidinylmethyl)-
3-pyr-me-pyrrolidine
3-(1-pyrrolidinylmethyl)-pyridine
YFCWBKBNFCDPDF-UHFFFAOYSA-N
SCHEMBL1538320
DTXSID90190489
Z232680520
EN300-1196740
3-[(pyrrolidin-1-yl)methyl]pyridine

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Sodium-dependent serotonin transporter	Homo sapiens (human)	Ki	10.0000	0.0000	0.7048	8.1930	AID661016
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
monoamine transport	Sodium-dependent serotonin transporter	Homo sapiens (human)
response to hypoxia	Sodium-dependent serotonin transporter	Homo sapiens (human)
neurotransmitter transport	Sodium-dependent serotonin transporter	Homo sapiens (human)
response to nutrient	Sodium-dependent serotonin transporter	Homo sapiens (human)
memory	Sodium-dependent serotonin transporter	Homo sapiens (human)
circadian rhythm	Sodium-dependent serotonin transporter	Homo sapiens (human)
response to xenobiotic stimulus	Sodium-dependent serotonin transporter	Homo sapiens (human)
response to toxic substance	Sodium-dependent serotonin transporter	Homo sapiens (human)
positive regulation of gene expression	Sodium-dependent serotonin transporter	Homo sapiens (human)
positive regulation of serotonin secretion	Sodium-dependent serotonin transporter	Homo sapiens (human)
negative regulation of cerebellar granule cell precursor proliferation	Sodium-dependent serotonin transporter	Homo sapiens (human)
negative regulation of synaptic transmission, dopaminergic	Sodium-dependent serotonin transporter	Homo sapiens (human)
response to estradiol	Sodium-dependent serotonin transporter	Homo sapiens (human)
social behavior	Sodium-dependent serotonin transporter	Homo sapiens (human)
vasoconstriction	Sodium-dependent serotonin transporter	Homo sapiens (human)
sperm ejaculation	Sodium-dependent serotonin transporter	Homo sapiens (human)
negative regulation of neuron differentiation	Sodium-dependent serotonin transporter	Homo sapiens (human)
positive regulation of cell cycle	Sodium-dependent serotonin transporter	Homo sapiens (human)
negative regulation of organ growth	Sodium-dependent serotonin transporter	Homo sapiens (human)
behavioral response to cocaine	Sodium-dependent serotonin transporter	Homo sapiens (human)
enteric nervous system development	Sodium-dependent serotonin transporter	Homo sapiens (human)
brain morphogenesis	Sodium-dependent serotonin transporter	Homo sapiens (human)
serotonin uptake	Sodium-dependent serotonin transporter	Homo sapiens (human)
membrane depolarization	Sodium-dependent serotonin transporter	Homo sapiens (human)
platelet aggregation	Sodium-dependent serotonin transporter	Homo sapiens (human)
cellular response to retinoic acid	Sodium-dependent serotonin transporter	Homo sapiens (human)
cellular response to cGMP	Sodium-dependent serotonin transporter	Homo sapiens (human)
regulation of thalamus size	Sodium-dependent serotonin transporter	Homo sapiens (human)
conditioned place preference	Sodium-dependent serotonin transporter	Homo sapiens (human)
sodium ion transmembrane transport	Sodium-dependent serotonin transporter	Homo sapiens (human)
amino acid transport	Sodium-dependent serotonin transporter	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
integrin binding	Sodium-dependent serotonin transporter	Homo sapiens (human)
monoatomic cation channel activity	Sodium-dependent serotonin transporter	Homo sapiens (human)
neurotransmitter transmembrane transporter activity	Sodium-dependent serotonin transporter	Homo sapiens (human)
serotonin:sodium:chloride symporter activity	Sodium-dependent serotonin transporter	Homo sapiens (human)
protein binding	Sodium-dependent serotonin transporter	Homo sapiens (human)
monoamine transmembrane transporter activity	Sodium-dependent serotonin transporter	Homo sapiens (human)
antiporter activity	Sodium-dependent serotonin transporter	Homo sapiens (human)
syntaxin-1 binding	Sodium-dependent serotonin transporter	Homo sapiens (human)
cocaine binding	Sodium-dependent serotonin transporter	Homo sapiens (human)
sodium ion binding	Sodium-dependent serotonin transporter	Homo sapiens (human)
identical protein binding	Sodium-dependent serotonin transporter	Homo sapiens (human)
nitric-oxide synthase binding	Sodium-dependent serotonin transporter	Homo sapiens (human)
actin filament binding	Sodium-dependent serotonin transporter	Homo sapiens (human)
serotonin binding	Sodium-dependent serotonin transporter	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
plasma membrane	Sodium-dependent serotonin transporter	Homo sapiens (human)
focal adhesion	Sodium-dependent serotonin transporter	Homo sapiens (human)
endosome membrane	Sodium-dependent serotonin transporter	Homo sapiens (human)
endomembrane system	Sodium-dependent serotonin transporter	Homo sapiens (human)
presynaptic membrane	Sodium-dependent serotonin transporter	Homo sapiens (human)
membrane raft	Sodium-dependent serotonin transporter	Homo sapiens (human)
synapse	Sodium-dependent serotonin transporter	Homo sapiens (human)
postsynaptic membrane	Sodium-dependent serotonin transporter	Homo sapiens (human)
serotonergic synapse	Sodium-dependent serotonin transporter	Homo sapiens (human)
synapse	Sodium-dependent serotonin transporter	Homo sapiens (human)
plasma membrane	Sodium-dependent serotonin transporter	Homo sapiens (human)
neuron projection	Sodium-dependent serotonin transporter	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (47)

Assay ID	Title	Year	Journal	Article
AID661020	Inhibition of M3 muscarinic receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663181	Inhibition of alpha1B adrenergic receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663200	Inhibition of H3 receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663190	Inhibition of Ca2+ channel	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663180	Inhibition of alpha1A adrenergic receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663209	Inhibition of 5-HT3 receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663192	Inhibition of D2 dopamine receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663185	Inhibition of alpha2C adrenergic receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID661028	Displacement of [3H]DTG from sigma2 receptor in human PC12 cells at 10 uM	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663208	Inhibition of 5-HT2C receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663182	Inhibition of alpha1D adrenergic receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663201	Inhibition of H4 receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663211	Inhibition of 5-HT6 receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663195	Inhibition of D5 dopamine receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663202	Inhibition of 5-HT1A receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663184	Inhibition of alpha2B adrenergic receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663188	Inhibition of beta3 adrenergic receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663193	Inhibition of D3 dopamine receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663207	Inhibition of 5-HT2B receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663189	Inhibition of BZP receptor in rat brain	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663204	Inhibition of 5-HT1D receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID661025	Inhibition of mu opioid receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID661027	Displacement of [3H](+)-pentazocine from sigma1 receptor in rat brain homogenate at 10 uM	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663187	Inhibition of beta2 adrenergic receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID661024	Inhibition of kappa opioid receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663210	Inhibition of 5-HT5A receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID661019	Inhibition of M2 muscarinic receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663194	Inhibition of D4 dopamine receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID661067	Inhibition of NET at 10 uM	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663203	Inhibition of 5-HT1B receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663197	Inhibition of GABA-A receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663191	Inhibition of D1 dopamine receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID661062	Inhibition of NMDA receptor PCP binding site at 10 uM	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663183	Inhibition of alpha2A adrenergic receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663206	Inhibition of 5-HT2A receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663198	Inhibition of H1 receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID661022	Inhibition of M5 muscarinic receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID661044	Inhibition of DAT at 10 uM	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID146485	Binding affinity towards nicotinic acetylcholine receptor alpha4-beta2 from rat brain homogenates	2004	Bioorganic & medicinal chemistry letters, Jan-19, Volume: 14, Issue:2	3-(4-Aminobutyn-1-yl)pyridines: binding at alpha 4 beta 2 nicotinic cholinergic receptors.
AID661015	Inhibition of 5-HT7 receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID661016	Inhibition of SERT	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID661023	Inhibition of delta opioid receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663205	Inhibition of 5-HT1E receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663186	Inhibition of beta1 adrenergic receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID661018	Inhibition of M1 muscarinic receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID661021	Inhibition of M4 muscarinic receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
AID663199	Inhibition of H2 receptor	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (40.00)	18.2507
2000's	2 (40.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
arecoline Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.. arecoline : A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.	1.97	1	enoate ester; methyl ester; pyridine alkaloid; tetrahydropyridine	metabolite; muscarinic agonist
N-methyl-N-(3-pyridylmethyl)amine [no description available]	2.02	1	aralkylamine
nicotine (S)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.	2.91	4	3-(1-methylpyrrolidin-2-yl)pyridine	anxiolytic drug; biomarker; immunomodulator; mitogen; neurotoxin; nicotinic acetylcholine receptor agonist; peripheral nervous system drug; phytogenic insecticide; plant metabolite; psychotropic drug; teratogenic agent; xenobiotic
isoarecolone methiodide isoarecolone methiodide: inhibits nicotine binding	1.97	1
cocaine Cocaine: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.. cocaine : A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.	1.98	1	benzoate ester; methyl ester; tertiary amino compound; tropane alkaloid	adrenergic uptake inhibitor; central nervous system stimulant; dopamine uptake inhibitor; environmental contaminant; local anaesthetic; mouse metabolite; plant metabolite; serotonin uptake inhibitor; sodium channel blocker; sympathomimetic agent; vasoconstrictor agent; xenobiotic
trans-metanicotine metanicotine: RN given refers to parent cpd with unspecified isomeric designation	2.02	1

n-(3-pyridylmethyl)pyrrolidine

Description

Cross-References

Synonyms (20)

Protein Targets (1)

Inhibition Measurements

Biological Processes (31)

Molecular Functions (14)

Ceullar Components (10)

Bioassays (47)

Research

Studies (5)

Market Indicators

Research Demand Index: 12.58

Study Types

n-(3-pyridylmethyl)pyrrolidine

Description

Cross-References

Synonyms (20)

Protein Targets (1)

Inhibition Measurements

Biological Processes (31)

Molecular Functions (14)

Ceullar Components (10)

Bioassays (47)

Research

Studies (5)

Market Indicators

Research Demand Index: 12.58

Study Types

Related Drugs (6)

Related Conditions (0)