Compounds > n-(2-hydroxypropyl)-n-nitrosourea
Page last updated: 2024-12-07

n-(2-hydroxypropyl)-n-nitrosourea

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N-(2-hydroxypropyl)-N-nitrosourea: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID114735
CHEMBL ID447523
MeSH IDM0111133

Synonyms (18)

Synonym
n-nitroso-(2-hydroxy-n-propyl)urea
1-(2-hydroxypropyl)-1-nitrosourea
ccris 1853
brn 5923588
nitrosoisopropanolurea
urea, 1-(2-hydroxypropyl)-1-nitroso-
n-(2-hydroxypropyl)-n-nitrosourea
nitroso-2-hydroxy-n-propylurea
CHEMBL447523
71752-69-7
AKOS006277069
7ri4y77iu8 ,
unii-7ri4y77iu8
urea, n-(2-hydroxypropyl)-n-nitroso-
nitroso-2-hydroxypropylurea
DTXSID00992390
n-(2-hydroxypropyl)-n-nitrosocarbamimidic acid
Q27268758
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID24150Half life in 0.067 M (D20), pH = 6.01985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Decomposition reactions of (hydroxyalkyl) nitrosoureas and related compounds: possible relationship to carcinogenicity.
AID24155Half life in 0.10 M (D20), pH = 7.41985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Decomposition reactions of (hydroxyalkyl) nitrosoureas and related compounds: possible relationship to carcinogenicity.
AID24153Half life in 0.067 M buffer, pH = 7.41985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Decomposition reactions of (hydroxyalkyl) nitrosoureas and related compounds: possible relationship to carcinogenicity.
AID24149Half life in 0.067 M (D20), pH = 5.51985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Decomposition reactions of (hydroxyalkyl) nitrosoureas and related compounds: possible relationship to carcinogenicity.
AID24152Half life in 0.067 M (D2O), pH = 7.41985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Decomposition reactions of (hydroxyalkyl) nitrosoureas and related compounds: possible relationship to carcinogenicity.
AID24154Half life in 0.067 M buffer, pH = 81985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Decomposition reactions of (hydroxyalkyl) nitrosoureas and related compounds: possible relationship to carcinogenicity.
AID24151Half life in 0.067 M (D20), pH = 6.51985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Decomposition reactions of (hydroxyalkyl) nitrosoureas and related compounds: possible relationship to carcinogenicity.
AID24148Half life in 0.01 M HClO4, pH = 3.01985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Decomposition reactions of (hydroxyalkyl) nitrosoureas and related compounds: possible relationship to carcinogenicity.
AID24157Half life in buffer1985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Decomposition reactions of (hydroxyalkyl) nitrosoureas and related compounds: possible relationship to carcinogenicity.
AID24156Half life in 0.10 M buffer, pH = 7.41985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Decomposition reactions of (hydroxyalkyl) nitrosoureas and related compounds: possible relationship to carcinogenicity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (60.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.60

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.60 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.39 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.60)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
methylnitrosourea
Methylnitrosourea: A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.. N-methyl-N-nitrosourea : A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.		1.9810N-nitrosoureasalkylating agent;
carcinogenic agent;
mutagen;
teratogenic agent
ethylnitrosourea
Ethylnitrosourea: A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.. N-ethyl-N-nitrosourea : A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups.		2.3720N-nitrosoureasalkylating agent;
carcinogenic agent;
genotoxin;
mutagen
diisopropanolnitrosamine
diisopropanolnitrosamine: experimental carcinogen. N,N-bis(2-hydroxypropyl)nitrosamine : A nitrosamine that is dipropylamine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. It is a genotoxic carcinogen, targeting the lung, liver, thyroid, and kidney.		1.9810diol;
nitrosamine;
secondary alcohol		carcinogenic agent
nitrosobis(2-oxopropyl)amine
nitrosobis(2-oxopropyl)amine: structure. nitrosobis(2-oxopropyl)amine : A nitrosamine that is iminodiacetone that is substituted by a nitroso group at the N-atom. It induces pancreatic ductal adenocarcinomas in Syrian golden hamsters (other rodents are not susceptible).		1.9810ketone;
nitrosamine		carcinogenic agent
oxazolidin-2-one
Oxazolidinones: Derivatives of oxazolidin-2-one. They represent an important class of synthetic antibiotic agents.. oxazolidin-2-one : An oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2.. oxazolidinone : An oxazolidine containing one or more oxo groups.		2.3720carbamate ester;
oxazolidinone		metabolite
1-(2-hydroxyethyl)-1-nitrosourea
1-(2-hydroxyethyl)-1-nitrosourea: structure		2.6530
3-nitroso-2-oxazolidone
3-nitroso-2-oxazolidone: structure given in first source		2.6530
transforming growth factor alpha
Transforming Growth Factor alpha: An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form which binds to the EGF RECEPTOR.		1.9810
ConditionIndicatedRelationship StrengthStudiesTrials
Experimental Neoplasms
[description not available]		01.9610
Germinoblastoma
[description not available]		01.9610
Benign Neoplasms
[description not available]		01.9610
Lymphoma
A general term for various neoplastic diseases of the lymphoid tissue.		01.9610
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		01.9610
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.		01.9810
Cancer of Pancreas
[description not available]		01.9810
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).		01.9810