n-(2-hydroxypropyl)-n-nitrosourea

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N-(2-hydroxypropyl)-N-nitrosourea: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	114735
CHEMBL ID	447523
MeSH ID	M0111133

Synonyms (18)

Synonym
n-nitroso-(2-hydroxy-n-propyl)urea
1-(2-hydroxypropyl)-1-nitrosourea
ccris 1853
brn 5923588
nitrosoisopropanolurea
urea, 1-(2-hydroxypropyl)-1-nitroso-
n-(2-hydroxypropyl)-n-nitrosourea
nitroso-2-hydroxy-n-propylurea
CHEMBL447523
71752-69-7
AKOS006277069
7ri4y77iu8 ,
unii-7ri4y77iu8
urea, n-(2-hydroxypropyl)-n-nitroso-
nitroso-2-hydroxypropylurea
DTXSID00992390
n-(2-hydroxypropyl)-n-nitrosocarbamimidic acid
Q27268758

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay ID	Title	Year	Journal	Article
AID24150	Half life in 0.067 M (D20), pH = 6.0	1985	Journal of medicinal chemistry, Aug, Volume: 28, Issue:8	Decomposition reactions of (hydroxyalkyl) nitrosoureas and related compounds: possible relationship to carcinogenicity.
AID24155	Half life in 0.10 M (D20), pH = 7.4	1985	Journal of medicinal chemistry, Aug, Volume: 28, Issue:8	Decomposition reactions of (hydroxyalkyl) nitrosoureas and related compounds: possible relationship to carcinogenicity.
AID24153	Half life in 0.067 M buffer, pH = 7.4	1985	Journal of medicinal chemistry, Aug, Volume: 28, Issue:8	Decomposition reactions of (hydroxyalkyl) nitrosoureas and related compounds: possible relationship to carcinogenicity.
AID24149	Half life in 0.067 M (D20), pH = 5.5	1985	Journal of medicinal chemistry, Aug, Volume: 28, Issue:8	Decomposition reactions of (hydroxyalkyl) nitrosoureas and related compounds: possible relationship to carcinogenicity.
AID24152	Half life in 0.067 M (D2O), pH = 7.4	1985	Journal of medicinal chemistry, Aug, Volume: 28, Issue:8	Decomposition reactions of (hydroxyalkyl) nitrosoureas and related compounds: possible relationship to carcinogenicity.
AID24154	Half life in 0.067 M buffer, pH = 8	1985	Journal of medicinal chemistry, Aug, Volume: 28, Issue:8	Decomposition reactions of (hydroxyalkyl) nitrosoureas and related compounds: possible relationship to carcinogenicity.
AID24151	Half life in 0.067 M (D20), pH = 6.5	1985	Journal of medicinal chemistry, Aug, Volume: 28, Issue:8	Decomposition reactions of (hydroxyalkyl) nitrosoureas and related compounds: possible relationship to carcinogenicity.
AID24148	Half life in 0.01 M HClO4, pH = 3.0	1985	Journal of medicinal chemistry, Aug, Volume: 28, Issue:8	Decomposition reactions of (hydroxyalkyl) nitrosoureas and related compounds: possible relationship to carcinogenicity.
AID24157	Half life in buffer	1985	Journal of medicinal chemistry, Aug, Volume: 28, Issue:8	Decomposition reactions of (hydroxyalkyl) nitrosoureas and related compounds: possible relationship to carcinogenicity.
AID24156	Half life in 0.10 M buffer, pH = 7.4	1985	Journal of medicinal chemistry, Aug, Volume: 28, Issue:8	Decomposition reactions of (hydroxyalkyl) nitrosoureas and related compounds: possible relationship to carcinogenicity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (60.00)	18.7374
1990's	2 (40.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.60

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.60 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.39 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.60)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
methylnitrosourea Methylnitrosourea: A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.. N-methyl-N-nitrosourea : A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.	1.98	1	N-nitrosoureas	alkylating agent; carcinogenic agent; mutagen; teratogenic agent
ethylnitrosourea Ethylnitrosourea: A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.. N-ethyl-N-nitrosourea : A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups.	2.37	2	N-nitrosoureas	alkylating agent; carcinogenic agent; genotoxin; mutagen
diisopropanolnitrosamine diisopropanolnitrosamine: experimental carcinogen. N,N-bis(2-hydroxypropyl)nitrosamine : A nitrosamine that is dipropylamine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. It is a genotoxic carcinogen, targeting the lung, liver, thyroid, and kidney.	1.98	1	diol; nitrosamine; secondary alcohol	carcinogenic agent
nitrosobis(2-oxopropyl)amine nitrosobis(2-oxopropyl)amine: structure. nitrosobis(2-oxopropyl)amine : A nitrosamine that is iminodiacetone that is substituted by a nitroso group at the N-atom. It induces pancreatic ductal adenocarcinomas in Syrian golden hamsters (other rodents are not susceptible).	1.98	1	ketone; nitrosamine	carcinogenic agent
oxazolidin-2-one Oxazolidinones: Derivatives of oxazolidin-2-one. They represent an important class of synthetic antibiotic agents.. oxazolidin-2-one : An oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2.. oxazolidinone : An oxazolidine containing one or more oxo groups.	2.37	2	carbamate ester; oxazolidinone	metabolite
1-(2-hydroxyethyl)-1-nitrosourea 1-(2-hydroxyethyl)-1-nitrosourea: structure	2.65	3
3-nitroso-2-oxazolidone 3-nitroso-2-oxazolidone: structure given in first source	2.65	3
transforming growth factor alpha Transforming Growth Factor alpha: An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form which binds to the EGF RECEPTOR.	1.98	1

Condition	Relationship Strength	Studies
Experimental Neoplasms [description not available]	1.96	1
Germinoblastoma [description not available]	1.96	1
Benign Neoplasms [description not available]	1.96	1
Lymphoma A general term for various neoplastic diseases of the lymphoid tissue.	1.96	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	1.96	1
Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	1.98	1
Cancer of Pancreas [description not available]	1.98	1
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	1.98	1

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