Compounds > n-(2-cyanoethylene)urea
Page last updated: 2024-12-06

n-(2-cyanoethylene)urea

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N-(2-cyanoethylene)urea: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID41854
CHEMBL ID146639
SCHEMBL ID3155911
MeSH IDM0049281

Synonyms (14)

Synonym
2-cyano-1-aziridinecarboxamide
1-aziridinecarboxamide, 2-cyano-
n-(2-cyanaethylene)harnstoff [german]
brn 0472019
n-(2-cyanoethylene)urea
CHEMBL146639
2-cyanoaziridine-1-carboxamide
AKOS006277906
n-(2-cyanaethylene)harnstoff
5-22-01-00010 (beilstein handbook reference)
56368-59-3
SCHEMBL3155911
DTXSID60971803
2-cyanoaziridine-1-carboximidic acid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID98575Inhibition of cell growth in (L1210 leukemia) MDR cells determined by MTT assay1999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Novel antitumor 2-cyanoaziridine-1-carboxamides.
AID104061Inhibition of cell growth in (MCF7 breast) mitox cell line1999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Novel antitumor 2-cyanoaziridine-1-carboxamides.
AID8245Inhibition of cell growth in drug resistant 8226 myeloma cell line1999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Novel antitumor 2-cyanoaziridine-1-carboxamides.
AID9031Inhibition of cell growth in (A-549) lung cell line1999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Novel antitumor 2-cyanoaziridine-1-carboxamides.
AID100790Cytotoxicity against sensitive L1210 murine leukemia cells by MTT assay2004Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1
Chemical basis for the biological activity of imexon and related cyanoaziridines.
AID8246Inhibition of cell growth in drug sensitive 8226 myeloma cell line1999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Novel antitumor 2-cyanoaziridine-1-carboxamides.
AID7704Inhibition of cell growth in (A375) melan cell line1999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Novel antitumor 2-cyanoaziridine-1-carboxamides.
AID100789Cytotoxicity against multidrug resistant (MDR) L1210 murine leukemia cells by MTT assay2004Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1
Chemical basis for the biological activity of imexon and related cyanoaziridines.
AID145903Inhibition of cell growth in (OVCAR-3) ovarian cell line1999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Novel antitumor 2-cyanoaziridine-1-carboxamides.
AID104060Inhibition of cell growth in (MCF7 breast) dox cell line1999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Novel antitumor 2-cyanoaziridine-1-carboxamides.
AID143572Cytotoxicity against multidrug resistant (MDR) human myeloma 8226 cells by MTT assay2004Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1
Chemical basis for the biological activity of imexon and related cyanoaziridines.
AID216584Inhibition of cell growth in drug resistant WiDr colon cell line1999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Novel antitumor 2-cyanoaziridine-1-carboxamides.
AID104062Inhibition of cell growth in drug sensitive MCF-7 breast cell line1999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Novel antitumor 2-cyanoaziridine-1-carboxamides.
AID216585Inhibition of cell growth in drug sensitive WiDr colon cell line1999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Novel antitumor 2-cyanoaziridine-1-carboxamides.
AID98576Inhibition of cell growth in drug sensitive L1210 leukemia cell line determined by MTT assay1999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Novel antitumor 2-cyanoaziridine-1-carboxamides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (40.00)18.7374
1990's1 (20.00)18.2507
2000's1 (20.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.66 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.66)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		2.6630isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
3-chloro-4-(dichloromethyl)-5-hydroxy-2(5h)-furanone
3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone: structure given in first source		2.0510butenolide
mepivacaine
[no description available]		210
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Esophagus
[description not available]		01.9610
Benign Neoplasms
[description not available]		02.3620
Cancer of Stomach
[description not available]		01.9610
Esophageal Neoplasms
Tumors or cancer of the ESOPHAGUS.		01.9610
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.3620
Stomach Neoplasms
Tumors or cancer of the STOMACH.		01.9610
Carcinoma, Ehrlich Tumor
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.		01.9510