Compounds > n-(2-cyanoethyl)valine

Page last updated: 2024-11-12

n-(2-cyanoethyl)valine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N-(2-cyanoethyl)valine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	11665476
SCHEMBL ID	5809120
MeSH ID	M0240882

Synonyms (10)

Synonym
l-valine, n-(2-cyanoethyl)-
n-(2-cyanoethyl)valine
n-(2-cyanoethyl)-l-valine
51078-49-0
SCHEMBL5809120
n-cyanoethylvaline
DTXSID90470238
AKOS030254643
(2s)-2-(2-cyanoethylamino)-3-methylbutanoic acid
(2s)-2-[(2-cyanoethyl)amino]-3-methylbutanoic acid

Research Excerpts

Dosage Studied

Excerpt	Relevance	Reference
" A close to linear dose-response relationship was found for adduct formation in rats treated with ACN by gavage."	( Monitoring of exposure to acrylonitrile by determination of N-(2-cyanoethyl)valine at the N-terminal position of haemoglobin. Bailey, E; Borba, H; Farmer, PB; Lawrence, RM; Lynce, N; Monteiro, M; Proença, MJ; Rueff, J; Sweetman, GM; Tavares, R, 1996)	0.54
" We further explored the dose-response relationship of miR-124 and let-7a with two biomarkers of tobacco exposure and found that this relationship was affected by adjustments based on age, pack-year and gender."	( Quantification of plasma microRNAs in a group of healthy smokers, ex-smokers and non-smokers and correlation to biomarkers of tobacco exposure. Banerjee, A; Camacho, OM; Minet, E; Waters, D, 2015)	0.42
" Dose-response relationships were quantified by Generalized Additive Models (GAMs)."	( Short-term health effects in the general population following a major train accident with acrylonitrile in Belgium. Bader, M; De Cremer, K; De Paepe, P; De Smedt, T; Fierens, S; Göen, T; Mertens, B; Nemery, B; Schettgen, T; Simons, K; Stove, C; Van Loco, J; Van Nieuwenhuyse, A; Van Overmeire, I; Van Oyen, H; Vleminckx, C, 2016)	0.43
" A dose-response relation was observed between the CEV concentrations and the reporting of short-term health effects in the non-smokers."	( Short-term health effects in the general population following a major train accident with acrylonitrile in Belgium. Bader, M; De Cremer, K; De Paepe, P; De Smedt, T; Fierens, S; Göen, T; Mertens, B; Nemery, B; Schettgen, T; Simons, K; Stove, C; Van Loco, J; Van Nieuwenhuyse, A; Van Overmeire, I; Van Oyen, H; Vleminckx, C, 2016)	0.43

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (16.67)	18.2507
2000's	2 (16.67)	29.6817
2010's	8 (66.67)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.51

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.51 (24.57)
Research Supply Index	2.56 (2.92)
Research Growth Index	5.08 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.51)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
lactic acid Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.	2.15	1	0	2-hydroxy monocarboxylic acid	algal metabolite; Daphnia magna metabolite
valine Valine: A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.. valine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isopropyl group.. L-valine : The L-enantiomer of valine.	8.92	12	0	L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid; valine	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
ethylene Plastipore: high density polyethylene sponge biocompatible material; used as posts in dental bridges	2.1	1	0	alkene; gas molecular entity	plant hormone; refrigerant
ethylene oxide Ethylene Oxide: A colorless and flammable gas at room temperature and pressure. Ethylene oxide is a bactericidal, fungicidal, and sporicidal disinfectant. It is effective against most micro-organisms, including viruses. It is used as a fumigant for foodstuffs and textiles and as an agent for the gaseous sterilization of heat-labile pharmaceutical and surgical materials. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p794). oxirane : A saturated organic heteromonocyclic parent that is a three-membered heterocycle of two carbon atoms and one oxygen atom.	2.44	2	0	gas molecular entity; oxacycle; saturated organic heteromonocyclic parent	allergen; mouse metabolite; mutagen
acrylonitrile [no description available]	8.75	10	0	aliphatic nitrile; volatile organic compound	antifungal agent; carcinogenic agent; fungal metabolite; mutagen; polar aprotic solvent
thiocyanate thiocyanate: RN given refers to parent cpd. thiocyanate : A pseudohalide anion obtained by deprotonation of the thiol group of thiocyanic acid.	2.15	1	0	pseudohalide anion; sulfur molecular entity	human metabolite
nicotine (S)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.	2.11	1	0	3-(1-methylpyrrolidin-2-yl)pyridine	anxiolytic drug; biomarker; immunomodulator; mitogen; neurotoxin; nicotinic acetylcholine receptor agonist; peripheral nervous system drug; phytogenic insecticide; plant metabolite; psychotropic drug; teratogenic agent; xenobiotic
2-hydroxyethylvaline 2-hydroxyethylvaline: RN given refers to (DL)-isomer; RN for cpd without isomeric designation not available 11/88	2.74	3	0
cotinine Cotinine: The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.. (-)-cotinine : An N-alkylpyrrolidine that consists of N-methylpyrrolidinone bearing a pyridin-3-yl substituent at position C-5 (the 5S-enantiomer). It is an alkaloid commonly found in Nicotiana tabacum.	2.76	3	0	N-alkylpyrrolidine; pyridines; pyrrolidin-2-ones; pyrrolidine alkaloid	antidepressant; biomarker; human xenobiotic metabolite; plant metabolite

Condition	Indicated	Relationship Strength	Studies	Trials
Bilateral Headache [description not available]	0	2.13	1	0
Action Tremor [description not available]	0	2.13	1	0
Headache The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.	0	2.13	1	0
Nausea An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.	0	2.13	1	0
Tremor Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.	0	2.13	1	0
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	0	1.98	1	0