Compounds > n-(1-carboxyethyl)-alpha-(2-phenylethyl)glycyl-leucine, n-phenylamide
Page last updated: 2024-11-07

n-(1-carboxyethyl)-alpha-(2-phenylethyl)glycyl-leucine, n-phenylamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N-(1-carboxyethyl)-alpha-(2-phenylethyl)glycyl-leucine, N-phenylamide: RN refers to (L,L,S)-isomer; inhibits stromelysin; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID132967
MeSH IDM0225921

Synonyms (12)

Synonym
n-(1-carboxy-ethyl)-alpha-(2-phenyl-ethyl)glycine-leucine, n-phenylamide
l696,418
154096-58-9
n-(1-carboxyethyl)-alpha-(2-phenylethyl)glycyl-leucine, n-phenylamide
l-leucinamide, n-(1-carboxyethyl)-4-phenyl-l-2-aminobutanoyl-n-phenyl-, (s)-
cepe-gly-leu-pa
(s)-n-(1-carboxyethyl)-4-phenyl-l-2-aminobutanoyl-n-phenyl-l-leucinamide
l-696,418
l 696418
2-[[(2s)-1-[[(2s)-1-anilino-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid
DTXSID50934922
n-(1-hydroxy-1-{[1-hydroxy-4-methyl-1-(phenylimino)pentan-2-yl]imino}-4-phenylbutan-2-yl)alanine

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" Combination of a biphenylylethyl moiety at P1', a tert-butyl group at P2', and a methyl group at P3' produced orally bioavailable inhibitors as measured by an in vivo model of MMP-3 degradation of radiolabeled transferrin in the mouse pleural cavity."( Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides.
Axel, MG; Becker, JW; Bugianesi, RL; Caldwell, CG; Chapman, KT; Christen, AJ; Durette, PL; Esser, CK; Girotra, NN; Hagmann, WK; Harrison, RK; Kopka, IE; Lanza, TJ; Levorse, DA; MacCoss, M; Marcy, AI; McDonnell, J; Moore, VL; Niedzwiecki, L; Olszewski, JM; Owens, KA; Ponpipom, MM; Saphos, C; Simeone, JP; Visco, DM, 1997)		0.3
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's5 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.66 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.66)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
thymidine
[no description available]		1.9910pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
transferrin
Transferrin: An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.		1.9910
raffinose
Raffinose: A trisaccharide occurring in Australian manna (from Eucalyptus spp, Myrtaceae) and in cottonseed meal.. raffinose : A trisaccharide composed of alpha-D-galactopyranose, alpha-D-glucopyranose and beta-D-fructofuranose joined in sequence by 1->6 and 1<->2 glycosidic linkages, respectively.		1.9910raffinose family oligosaccharide;
trisaccharide		mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
phenylmercuric acetate
Phenylmercuric Acetate: A phenyl mercury compound used mainly as a fungicide. Has also been used as a herbicide, slimicide, and bacteriocide.		1.9910arylmercury compound;
benzenes
4-aminophenylmercuriacetate
4-aminophenylmercuriacetate: covalently linked to agarose for purification of FAD & COA with chromatography		1.9910
ConditionIndicatedRelationship StrengthStudiesTrials
Polyarthritis
[description not available]		01.9910
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		01.9910
Arthritis
Acute or chronic inflammation of JOINTS.		01.9910