Compounds > n-((3s)-1-azabicyclo(2.2.2)oct-3-yl)-1h-indazole-3-carboxamide hydrochloride
Page last updated: 2024-11-12

n-((3s)-1-azabicyclo(2.2.2)oct-3-yl)-1h-indazole-3-carboxamide hydrochloride

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10380472
CHEMBL ID5095032
SCHEMBL ID40976
MeSH IDM0553500

Synonyms (25)

Synonym
909910-22-1
mem 3454
mem3454
rg3487
rg-3487
SCHEMBL40976
O6J463N18M ,
n-((3s)-1-azabicyclo(2.2.2)oct-3-yl)-1h-indazole-3-carboxamide hydrochloride
facinicline hydrochloride
1h-indazole-3-carboxamide, n-(3s)-1-azabicyclo(2.2.2)oct-3-yl-, hydrochloride (1:1)
mem-3454
1h-indazole-3-carboxamide, n-(3s)-1-azabicyclo(2.2.2)oct-3-yl-, monohydrochloride
677305-02-1
unii-o6j463n18m
n-[(3s)-1-azabicyclo[2.2.2]oct-3-yl]-1h-indazole-3-carboxamide hydrochloride
Q27285409
facinicline hcl
677305-02-1(hcl)
MS-24446
facinicline (hydrochloride)
HY-108057A
CS-0081613
n-[(3s)-1-azabicyclo[2.2.2]octan-3-yl]-1h-indazole-3-carboxamide;hydrochloride
AKOS040749293
CHEMBL5095032

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
"6-mg/kg doses, producing a bell-shaped dose-response curve."( The alpha-7 nicotinic receptor partial agonist/5-HT3 antagonist RG3487 enhances cortical and hippocampal dopamine and acetylcholine release.
Felix, AR; Huang, M; Kwon, S; Lowe, D; Meltzer, HY; Santarelli, L; Wallace, T, 2014)		0.4
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.43

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.43 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.43)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (16.67%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
quinuclidines
Quinuclidines: A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms and contains an amine group.		2.1110quinuclidines;
saturated organic heterobicyclic parent
thiophenes
Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.		2.1110mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
indazoles
Indazoles: A group of heterocyclic aromatic organic compounds consisting of the fusion of BENZENE and PYRAZOLES.		4.7461indazole
isoxazoles
Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent.		2.1110isoxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
pnu 120596
1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea: an alpha7nAChR agonist; structure in first source		2.1110ureas
ConditionIndicatedRelationship StrengthStudiesTrials
Cognition Disorders
Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.		03.4811
Dementia Praecox
[description not available]		03.4811
Schizophrenia
A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.		15.4811