Compounds > n-((2-dimethylamino)ethyl)-9-aminoacridine-4-carboxamide
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n-((2-dimethylamino)ethyl)-9-aminoacridine-4-carboxamide

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Description

N-((2-dimethylamino)ethyl)-9-aminoacridine-4-carboxamide: RN given refers to parent cpd; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID128962
CHEMBL ID37656
SCHEMBL ID3365620
MeSH IDM0173977

Synonyms (15)

Synonym
9-amino-n-[2-(dimethylamino)ethyl]-4-acridinecarboxamide
n-((2-dimethylamino)ethyl)-9-aminoacridine-4-carboxamide
9-amino-n-(2-(dimethylamino)ethyl)-4-acridinecarboxamide
amino-n-(2-(dimehtylamino)ehtyl)acridine-4-carboxamide
brn 3623756
ccris 4455
9-amino-(n-(2-dimethylamino)ethyl)acridine-4-carboxamide
CHEMBL37656
SCHEMBL3365620
89459-43-8
9-amino-n-[2-(dimethylamino)ethyl]acridine-4-carboxamide
n-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide
9-amino-n-(2-(dimethylamino)ethyl)acridine-4-carboxamide
Q27456992
DTXSID701034053
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (102)

Assay IDTitleYearJournalArticle
AID54821Ratio T2/T1 of DNA dissociation constant of poly(dA-dT) from calf thymus1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID54972Dissociation constant of poly(dG-dC)DNA in calf thymus1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID54824Ratio T2/T1 of DNA dissociation constant from calf thymus1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID150673Inhibitory concentration required to reduce murine p388 leukemia cell number to 50% of control cultures1997Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
AID132732Percent increase in life span of compound-treated mice bearing P388 leukemia2002Journal of medicinal chemistry, Feb-14, Volume: 45, Issue:4
Kinetic studies of the binding of acridinecarboxamide topoisomerase poisons to DNA: implications for mode of binding of ligands with uncharged chromophores.
AID131655In vivo percent increase in lifespan was determined at a dose 4.5 mg/kg per day1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 49. 5-substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity.
AID221335In vivo percent increase in lifespan was determined against Lewis lung carcinoma (LL) cells at a dose 65 mg/kg/ day;IA denotes inactive1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 49. 5-substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity.
AID54263DNA-bound drug concentration in 0.1 SHE buffer at the concentration of 50 uM for equilibrium binding to calf thymus DNA1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
Kinetic and equilibrium binding studies of amsacrine-4-carboxamides: a class of asymmetrical DNA-intercalating agents which bind by threading through the DNA helix.
AID54978DNA dissociation constant from calf thymus1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID227384Fraction of the observed equilibrium absorbance change accounted in the kinetic analysis1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
Kinetic and equilibrium binding studies of amsacrine-4-carboxamides: a class of asymmetrical DNA-intercalating agents which bind by threading through the DNA helix.
AID231449Ratio IC50 of HCT-8 cells to IC50 of L1210 cells1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 49. 5-substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity.
AID228718Difference between log K of (AT) and log K of (GC) DNA binding1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID115506Percentage increase in lifespan of Lewis lung carcinoma tumor cell bearing animal compared to nontreated tumor bearing controls at given optimal dose; Not active1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Potential antitumor agents. 54. Chromophore requirements for in vivo antitumor activity among the general class of linear tricyclic carboxamides.
AID54971Dissociation constant of poly(dA-dT)DNA in calf thymus1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID54266Micelle-bound drug concentration in 0.1 SHE buffer at the concentration of 50 uM for equilibrium binding to calf thymus DNA1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
Kinetic and equilibrium binding studies of amsacrine-4-carboxamides: a class of asymmetrical DNA-intercalating agents which bind by threading through the DNA helix.
AID234408Percentage of the sum of the amplitudes evaluated in the kinetic experiment1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
Kinetic and equilibrium binding studies of amsacrine-4-carboxamides: a class of asymmetrical DNA-intercalating agents which bind by threading through the DNA helix.
AID131640In vivo percent increase in lifespan was determined against Lewis lung carcinoma (LL) cells at a dose 3 mg/kg/ day;inactive1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 49. 5-substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity.
AID120463Number of mice survived indefinitely out a group of 61984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Potential antitumor agents. 43. Synthesis and biological activity of dibasic 9-aminoacridine-4-carboxamides, a new class of antitumor agent.
AID119968Optimal intraperitoneal dose against Lewis lung carcinoma in mice1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Potential antitumor agents. 54. Chromophore requirements for in vivo antitumor activity among the general class of linear tricyclic carboxamides.
AID134971Percent increase in life span of compound-treated mice bearing or Lewis lung carcinoma; NA denotes not available2002Journal of medicinal chemistry, Feb-14, Volume: 45, Issue:4
Kinetic studies of the binding of acridinecarboxamide topoisomerase poisons to DNA: implications for mode of binding of ligands with uncharged chromophores.
AID20514Lipophilicity is expressed in Rm1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 49. 5-substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity.
AID133481In vivo optimal i.p. dose administered on days 1, 5, and 9 after i.p. inoculation of (10E6) P388 leukemia cells.1986Journal of medicinal chemistry, Apr, Volume: 29, Issue:4
Potential antitumor agents. 46. Structure-activity relationships for acridine monosubstituted derivatives of the antitumor agent N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide.
AID55626Time constant describing the dissociation profile of calf thymus DNA-drug complexes in 0.1 SHE buffer at 20 degree C1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
Kinetic and equilibrium binding studies of amsacrine-4-carboxamides: a class of asymmetrical DNA-intercalating agents which bind by threading through the DNA helix.
AID78974In vitro inhibitory activity was determined against Human colon tumor (HCT-8) cells.1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 49. 5-substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity.
AID131139Evaluated in vivo against P388 leukemia cells ( percent increase in life span of treated animals over that of control groups of tumor bearing untreated animals.)1986Journal of medicinal chemistry, Apr, Volume: 29, Issue:4
Potential antitumor agents. 46. Structure-activity relationships for acridine monosubstituted derivatives of the antitumor agent N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide.
AID78978In vitro cytotoxicity against HCT-8 human colon carcinoma cells.1986Journal of medicinal chemistry, Apr, Volume: 29, Issue:4
Potential antitumor agents. 46. Structure-activity relationships for acridine monosubstituted derivatives of the antitumor agent N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide.
AID55131Logarithm of association constant for binding to DNA by ethidium displacement1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID225780Association constant for binding to poly(dA-dT) DNA in 0.01 SHE buffer, measured by ethidium displacement method for equilibrium binding to calf thymus DNA1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
Kinetic and equilibrium binding studies of amsacrine-4-carboxamides: a class of asymmetrical DNA-intercalating agents which bind by threading through the DNA helix.
AID153868Percentage increase in life span treated animals over those of controls injected with P388 leukemia cells1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID20512Lipophilicity (Rm) (RP-TLC)1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Potential antitumor agents. 43. Synthesis and biological activity of dibasic 9-aminoacridine-4-carboxamides, a new class of antitumor agent.
AID162548Binding constant to Poly (dG-dC) determined by ethidium bromide displacement2002Journal of medicinal chemistry, Feb-14, Volume: 45, Issue:4
Kinetic studies of the binding of acridinecarboxamide topoisomerase poisons to DNA: implications for mode of binding of ligands with uncharged chromophores.
AID103306Percentage increase in life span of tumor bearing animals compared to non treated, tumor-bearing controls when treated at the optimal dose of 4.5 mg/kg/day intraperitoneally; IA denotes inactive1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 50. In vivo solid-tumor activity of derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
AID131654In vivo percent increase in lifespan was determined at a dose 3.0 mg/kg per day1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 49. 5-substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity.
AID54975Dissociation constant of poly(dG-dC)DNA in calf thymus1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID100240Inhibitory concentration required to reduce Lewis lung carcinoma cell number to 50% of control cultures1997Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
AID26592pKa values were determined spectrophotometrically in aqueous solution.1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 49. 5-substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity.
AID26532Logarithmic association constant determined by ethidium displacement from DNA co-polymers (adenine & thymine)1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Potential antitumor agents. 43. Synthesis and biological activity of dibasic 9-aminoacridine-4-carboxamides, a new class of antitumor agent.
AID55128Association constant for DNA binding by ethidium bromide displacement1986Journal of medicinal chemistry, Apr, Volume: 29, Issue:4
Potential antitumor agents. 46. Structure-activity relationships for acridine monosubstituted derivatives of the antitumor agent N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide.
AID232677Selectivity ratio of IC50 of HCT to IC50 of L1210 cell lines1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 50. In vivo solid-tumor activity of derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
AID131639In vivo percent increase in lifespan was determined against Lewis lung carcinoma (LL) cells at a dose 1.2 mg/kg/ day;inactive1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 49. 5-substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity.
AID131499In vivo percent increase in lifespan of drug-treated, (P388 cells)tumor bearing animals was determined1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 49. 5-substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity.
AID55127Binding constant for DNA by ethidium displacement1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Potential antitumor agents. 54. Chromophore requirements for in vivo antitumor activity among the general class of linear tricyclic carboxamides.
AID25340Base strength is expressed as pKa, determined in water at 25 degrees Centigrade by spectrophotometric method.1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 50. In vivo solid-tumor activity of derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
AID26533Logarithmic association constant determined by ethidium displacement from DNA co-polymers (G + C)1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Potential antitumor agents. 43. Synthesis and biological activity of dibasic 9-aminoacridine-4-carboxamides, a new class of antitumor agent.
AID234983Time constant describing the association profile of calf thymus DNA-drug complexes in 0.1 SHE buffer at 20 degree C after 1 min1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
Kinetic and equilibrium binding studies of amsacrine-4-carboxamides: a class of asymmetrical DNA-intercalating agents which bind by threading through the DNA helix.
AID54265Free drug concentration in 0.1 SHE buffer at the concentration of 50 uM; 9.4 x 10 e-3 epcilonfor equilibrium binding to calf thymus DNA1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
Kinetic and equilibrium binding studies of amsacrine-4-carboxamides: a class of asymmetrical DNA-intercalating agents which bind by threading through the DNA helix.
AID55123Binding constant (log K) for DNA by ethidium bromide displacement1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 49. 5-substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity.
AID78994Concentration required for 50% reduction of counted HCT-8 cells upon exposure for a period of 70h1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Potential antitumor agents. 43. Synthesis and biological activity of dibasic 9-aminoacridine-4-carboxamides, a new class of antitumor agent.
AID54827Ratio T3/T2 of DNA dissociation constant from calf thymus1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID54974DNA dissociation constant was determined from calf thymus1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID150522In vitro cell growth inhibitory activity against wild type P388 murine leukemia cell line (P388/W)1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Potential antitumor agents. 59. Structure-activity relationships for 2-phenylbenzimidazole-4-carboxamides, a new class of "minimal" DNA-intercalating agents which may not act via topoisomerase II.
AID162408Binding constant to Poly (dA-dT) determined by ethidium bromide displacement2002Journal of medicinal chemistry, Feb-14, Volume: 45, Issue:4
Kinetic studies of the binding of acridinecarboxamide topoisomerase poisons to DNA: implications for mode of binding of ligands with uncharged chromophores.
AID91917Inhibitory concentration required to reduce human Jurkat leukemia (JLC sensitive, wild type) cell number to 50% of control cultures1997Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
AID54969Dissociation constant of poly(dI-dC)DNA binding in calf thymus1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID54968Dissociation constant of poly(dG-dC)DNA binding in calf thymus1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID152987Ratio of IC50 value of P388/A and P388/W cell lines1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Potential antitumor agents. 59. Structure-activity relationships for 2-phenylbenzimidazole-4-carboxamides, a new class of "minimal" DNA-intercalating agents which may not act via topoisomerase II.
AID54976DNA dissociation constant from calf thymus1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID225923Association constant for binding to poly(dG-dC) DNA in 0.01 SHE buffer, measured by ethidium displacement method for equilibrium binding to calf thymus DNA1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
Kinetic and equilibrium binding studies of amsacrine-4-carboxamides: a class of asymmetrical DNA-intercalating agents which bind by threading through the DNA helix.
AID54826Ratio T3/T2 of DNA dissociation constant of poly(dG-dC) from calf thymus1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID98198Inhibition murine leukemia L1210 cell growth in culture1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 50. In vivo solid-tumor activity of derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
AID382900Cytotoxicity against human CCRF-CEM cells after 72 hrs2008Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
DNA threading bis(9-aminoacridine-4-carboxamides): effects of piperidine sidechains on DNA binding, cytotoxicity and cell cycle arrest.
AID119967Optimal intraperitoneal dose administered against P388 leukemia in mice1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Potential antitumor agents. 54. Chromophore requirements for in vivo antitumor activity among the general class of linear tricyclic carboxamides.
AID54823Ratio T2/T1 of DNA dissociation constant of poly(dI-dC) from calf thymus1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID133491In vivo optimal dose against LL cells drug administered intraperitoneally was determined1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 49. 5-substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity.
AID150523In vitro cell growth inhibitory activity against amsacrine-resistant P388 cell line (P388/A)1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Potential antitumor agents. 59. Structure-activity relationships for 2-phenylbenzimidazole-4-carboxamides, a new class of "minimal" DNA-intercalating agents which may not act via topoisomerase II.
AID55628Time constant describing the dissociation profile of calf thymus DNA-drug complexes in 0.1 SHE buffer at 20 degree C1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
Kinetic and equilibrium binding studies of amsacrine-4-carboxamides: a class of asymmetrical DNA-intercalating agents which bind by threading through the DNA helix.
AID20513Lipophilicity index (Rm) (HPLC)1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 50. In vivo solid-tumor activity of derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
AID131498In vivo percent increase in lifespan of drug-treated, (LL cells)tumor bearing animals was determined;ND denotes no data1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 49. 5-substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity.
AID55627Time constant describing the dissociation profile of calf thymus DNA-drug complexes in 0.1 SHE buffer at 20 degree C1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
Kinetic and equilibrium binding studies of amsacrine-4-carboxamides: a class of asymmetrical DNA-intercalating agents which bind by threading through the DNA helix.
AID229289Ratio of IC50 of Jurkat leukemia amsacrine (JLA) to the IC50 of Jurkat leukemia (JLC sensitive, wild type)1997Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
AID131653In vivo percent increase in lifespan was determined at a dose 1.2 mg/kg per day1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 49. 5-substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity.
AID231906Ratio between the ID50 values of L1210 and HCT-8 cell lines.1986Journal of medicinal chemistry, Apr, Volume: 29, Issue:4
Potential antitumor agents. 46. Structure-activity relationships for acridine monosubstituted derivatives of the antitumor agent N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide.
AID98762In vitro inhibition of Murine leukemia (L1210) cell growth.1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 49. 5-substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity.
AID98315Evaluated for concentration which when added to cultures of L1210 leukemia cells for a period of 70 hr reduces cell numbers of 50% of control cultures1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID55629Time constant describing the dissociation profile of calf thymus DNA-drug complexes in 0.1 SHE buffer at 20 degree C1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
Kinetic and equilibrium binding studies of amsacrine-4-carboxamides: a class of asymmetrical DNA-intercalating agents which bind by threading through the DNA helix.
AID382903Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G2/M phase at 10 times IC50 after 24 hrs by flow cytometry2008Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
DNA threading bis(9-aminoacridine-4-carboxamides): effects of piperidine sidechains on DNA binding, cytotoxicity and cell cycle arrest.
AID55126Binding constant to poly(dG-dC)DNA by ethidium bromide displacement1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 50. In vivo solid-tumor activity of derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
AID54822Ratio T2/T1 of DNA dissociation constant of poly(dG-dC) from calf thymus1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID133498In vivo optimal dose was determined against P388 cells after (ip) administration1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 49. 5-substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity.
AID131489In vivo increased lifespan in mice implanted intraperitoneally with wild type P388 murine leukemia cell line at the optimal dose of 4.5 mg/kg/day1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Potential antitumor agents. 59. Structure-activity relationships for 2-phenylbenzimidazole-4-carboxamides, a new class of "minimal" DNA-intercalating agents which may not act via topoisomerase II.
AID98488Concentration required to inhibit growth of murine leukemia (L1210) cells in culture1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Potential antitumor agents. 54. Chromophore requirements for in vivo antitumor activity among the general class of linear tricyclic carboxamides.
AID54967Dissociation constant of poly(dA-dT)DNA binding in calf thymus1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID55125Binding constant to poly(dA-dT)DNA by ethidium bromide displacement1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 50. In vivo solid-tumor activity of derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
AID25047Lipophilicity expressed as the negative logarithm of the equilibrium constant2002Journal of medicinal chemistry, Feb-14, Volume: 45, Issue:4
Kinetic studies of the binding of acridinecarboxamide topoisomerase poisons to DNA: implications for mode of binding of ligands with uncharged chromophores.
AID115369Percentage increase in lifespan of P388 tumor cell bearing animal compared to nontreated tumor bearing controls at given optimal dose.1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Potential antitumor agents. 54. Chromophore requirements for in vivo antitumor activity among the general class of linear tricyclic carboxamides.
AID78825Inhibition of human colon tumor (HCT-8) cell growth in culture1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 50. In vivo solid-tumor activity of derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
AID54970DNA dissociation constant from calf thymus1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID54264Free drug concentration in 0.1 SHE buffer at the concentration of 50 uM for equilibrium binding to calf thymus DNA1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
Kinetic and equilibrium binding studies of amsacrine-4-carboxamides: a class of asymmetrical DNA-intercalating agents which bind by threading through the DNA helix.
AID25217Compound was evaluated for ionizable constant, pKa1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Potential antitumor agents. 54. Chromophore requirements for in vivo antitumor activity among the general class of linear tricyclic carboxamides.
AID54973Dissociation constant of poly(dI-dC)DNA binding in calf thymus1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID234988Time constant describing the association profile of calf thymus DNA-drug complexes in 0.1 SHE buffer at 20 degree C after 2 min1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
Kinetic and equilibrium binding studies of amsacrine-4-carboxamides: a class of asymmetrical DNA-intercalating agents which bind by threading through the DNA helix.
AID98543Inhibition of L1210 cell growth by 50%2002Journal of medicinal chemistry, Feb-14, Volume: 45, Issue:4
Kinetic studies of the binding of acridinecarboxamide topoisomerase poisons to DNA: implications for mode of binding of ligands with uncharged chromophores.
AID115164Percentage increase in lifespan of treated animals over that of animals injected with tumor (10e6 P388 leukemia cells), at the optimal dose of 4.5 mg/(kg day)1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Potential antitumor agents. 43. Synthesis and biological activity of dibasic 9-aminoacridine-4-carboxamides, a new class of antitumor agent.
AID131656In vivo percent increase in lifespan was determined at a dose 6.7 mg/kg/day1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 49. 5-substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity.
AID229325Ratio of IC50 of mutant Jurkat leukemia (JLD) to the IC50 of Jurkat leukemia (JLC sensitive, wild type)1997Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
AID96647Concentration required for 50% reduction of counted L1210 cells upon exposure for a period of 70h1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Potential antitumor agents. 43. Synthesis and biological activity of dibasic 9-aminoacridine-4-carboxamides, a new class of antitumor agent.
AID131641In vivo percent increase in lifespan was determined against Lewis lung carcinoma (LL) cells at a dose 3.0 mg/kg/ day;inactive1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 49. 5-substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity.
AID54818Ratio T4/T3 of DNA dissociation constant from calf thymus1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID152666Compound administered intraperitoneally was evaluated for optimal dose (OD) given per day after inoculation of 10e 6 P388 leukemia cells for highest nontoxic dose1987Journal of medicinal chemistry, May, Volume: 30, Issue:5
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
AID55643Binding constant to poly[d(AT)] by ethidium bromide displacement1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Potential antitumor agents. 59. Structure-activity relationships for 2-phenylbenzimidazole-4-carboxamides, a new class of "minimal" DNA-intercalating agents which may not act via topoisomerase II.
AID96635In vitro cytotoxicity against L1210 leukemia cells1986Journal of medicinal chemistry, Apr, Volume: 29, Issue:4
Potential antitumor agents. 46. Structure-activity relationships for acridine monosubstituted derivatives of the antitumor agent N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide.
AID153863Percentage increase in life span of tumor bearing animals compared to non treated, tumor-bearing controls when treated at the optimal dose of 4.5 mg/kg/day intraperitoneally1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Potential antitumor agents. 50. In vivo solid-tumor activity of derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (50.00)18.7374
1990's3 (21.43)18.2507
2000's3 (21.43)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.40

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.40 (24.57)
Research Supply Index2.77 (2.92)
Research Growth Index4.17 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.40)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
amsacrine
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.. amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.		2.940acridines;
aromatic ether;
sulfonamide		antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
aminacrine
Aminacrine: A highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH indicator.. 9-aminoacridine : An aminoacridine that is acridine in which the hydrogen at position 9 is replaced by an amino group. A fluorescent dyd and topical antiseptic agent, it is used (usually as the hydrochloride salt) in eye drops for the treatment of superficial eye infections.		2.3720aminoacridines;
primary amino compound		acid-base indicator;
antiinfective agent;
antiseptic drug;
fluorescent dye;
MALDI matrix material;
mutagen
acridines
Acridines: Compounds that include the structure of acridine.. acridine : A polycyclic heteroarene that is anthracene in which one of the central CH groups is replaced by a nitrogen atom.		210acridines;
mancude organic heterotricyclic parent;
polycyclic heteroarene		genotoxin
n-(2'-(dimethylamino)ethyl)acridine-4-carboxamide
[no description available]		2.940
dactinomycin
Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)		2.0410actinomycinmutagen
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.8940
Experimental Leukemia
[description not available]		02.6630
Carcinoma, Anaplastic
[description not available]		02.3720
Cancer of Colon
[description not available]		02.6730
Cancer of Lung
[description not available]		02.8940
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		02.3720
Colonic Neoplasms
Tumors or cancer of the COLON.		02.6730
Lung Neoplasms
Tumors or cancer of the LUNG.		02.8940
Leukemia L 1210
[description not available]		02.3720
Adenocarcinoma, Basal Cell
[description not available]		01.9610
Adenocarcinoma
A malignant epithelial tumor with a glandular organization.		01.9610
Leucocythaemia
[description not available]		01.9910
Leukemia
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)		01.9910