Compounds > n(4)-methylcytosine
Page last updated: 2024-12-07

n(4)-methylcytosine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

n(4)-methylcytosine (4mC) is a modified base found in DNA, primarily in bacteria and some eukaryotes. It is formed by the methylation of cytosine at the N4 position. The formation of 4mC is catalyzed by DNA methyltransferases, and it plays a role in gene regulation and other cellular processes. 4mC is not as common in eukaryotic DNA as 5-methylcytosine (5mC), but it has been implicated in various biological functions. It is found in specific genomic regions, suggesting a potential role in gene expression regulation. Researchers are studying 4mC to understand its role in epigenetic regulation, DNA repair, and the development of cancer. Furthermore, understanding the functions of 4mC could have implications in developing novel therapeutic strategies.'

N(4)-methylcytosine : A pyrimidone that is cytosine bearing an N(4)-methyl substituent. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID122004
CHEBI ID21839
SCHEMBL ID19930
SCHEMBL ID13030167
MeSH IDM0117166

Synonyms (30)

Synonym
4n-methylcytosine
6220-47-9
6-(methylamino)-1h-pyrimidin-2-one
4-(methylamino)-2(1h)-pyrimidinone
4-METHYLAMINO-1H-PYRIMIDIN-2-ONE ,
n4-methylcytosine
CHEBI:21839
n(4)-methylcytosine
4-(methylamino)pyrimidin-2(1h)-one
4-(methylamino)pyrimidin-2-ol
2(1h)-pyrimidinone, 4-(methylamino)-
4-methylaminocytosine
AKOS006330221
4-(methylamino)-2-pyrimidinol
FT-0687997
AB60627
6-(methylamino)pyrimidin-2(1h)-one
SCHEMBL19930
SCHEMBL13030167
PJKKQFAEFWCNAQ-UHFFFAOYSA-N
4-(methylamino)-2(1h)-pyrimidinone #
J-513768
6-(methylamino)-2(1h)-pyrimidinone
Q15632688
AMY16237
A935251
noname_3509
DTXSID40902933
F81507
CS-0366447
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
aminopyrimidineA member of the class of pyrimidines that is pyrimidine substituted by at least one amino group and its derivatives.
pyrimidoneA pyrimidine carrying one or more oxo substituents.
methylcytosine
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (32)

TimeframeStudies, This Drug (%)All Drugs %
pre-199012 (37.50)18.7374
1990's6 (18.75)18.2507
2000's4 (12.50)29.6817
2010's6 (18.75)24.3611
2020's4 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.45

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.45 (24.57)
Research Supply Index3.53 (2.92)
Research Growth Index4.98 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.45)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other33 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
adenine
[no description available]		3.62906-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
cytosine
[no description available]		4.74300aminopyrimidine;
pyrimidine nucleobase;
pyrimidone		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
hydrogen
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.		1.9710elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
sulfites
Sulfites: Inorganic salts of sulfurous acid.. sulfites : Any sulfurous acid derivative that is a salt or an ester of sulfurous acid.. organosulfonate oxoanion : An organic anion obtained by deprotonation of the sufonate group(s) of any organosulfonic acid.. sulfite : A sulfur oxoanion that is the conjugate base of hydrogen sulfite (H2SO3).		2.4420divalent inorganic anion;
sulfur oxide;
sulfur oxoanion
uracil
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder		210pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
deuterium
Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.		1.9710dihydrogen
5-methylcytosine
5-Methylcytosine: A methylated nucleotide base found in eukaryotic DNA. In ANIMALS, the DNA METHYLATION of CYTOSINE to form 5-methylcytosine is found primarily in the palindromic sequence CpG. In PLANTS, the methylated sequence is CpNpGp, where N can be any base.. 5-methylcytosine : A pyrimidine that is a derivative of cytosine, having a methyl group at the 5-position.		3.77110methylcytosine;
pyrimidines		human metabolite
6-methyladenine
6-methyladenine: structure. 6-methyladenine : A methyladenine that is 9H-purin-6-amine substituted by a methyl group at the amino nitrogen.		3.62906-alkylaminopurine;
methyladenine		human metabolite
hydrogen sulfite
[no description available]		2.1110sulfur oxoanionhuman metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
5-propynyluracil
5-propynyluracil: a PYaraU metabolite		210
2',3'-dideoxyguanosine 5'-triphosphate
[no description available]		2.0210
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Stomach
[description not available]		01.9710
Gastric Ulcer
[description not available]		01.9710
Stomach Neoplasms
Tumors or cancer of the STOMACH.		01.9710
Stomach Ulcer
Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).		01.9710
Cell Transformation, Viral
An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.		01.9710