Compounds > n(4)-acetylsulfisoxazole
Page last updated: 2024-11-07

n(4)-acetylsulfisoxazole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID160743
CHEMBL ID725
SCHEMBL ID7857278
MeSH IDM0079704

Synonyms (28)

Synonym
bdbm50034479
n-[4-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)-phenyl]-acetamide
n-{4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl}acetamide
STL357465
OPREA1_428841
OPREA1_848478
HMS2093L11
CHEMBL725 ,
n4-acetyl sulfisoxazole
AKOS002262082
n-[4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]acetamide
nsc759138
pharmakon1600-01505461
4206-74-0
n-(4-(((3,4-dimethyl-5-isoxazolyl)amino)sulfonyl)phenyl)acetamide
n(4)-acetylsulfisoxazole
CCG-213456
SCHEMBL7857278
n-(4-([(3,4-dimethyl-5-isoxazolyl)amino]sulfonyl)phenyl)acetamide #
n-(p-(3,4-dimethyl-5-isoxazolylaminosulfonyl)phenyl)acetamide
UTVCPAPWORAKEV-UHFFFAOYSA-N
AB01563087_01
DTXSID30194901
SR-05000002018-1
sr-05000002018
SBI-0206809.P001
BRD-K05009775-001-01-2
n-(4-(n-(3,4-dimethylisoxazol-5-yl)sulfamoyl)phenyl)acetamide

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" The tmax value and plasma half-life of sulfisoxazole were significantly longer, and the total body and renal clearances of the drug decreased in the elderly subjects."( Pharmacokinetics of sulfisoxazole in young and elderly subjects.
Barbeau, G; Bélanger, PM; Boisvert, A, 1984)		0.27
" The loss of weight up to 44 per cent within an individual over a year's time had no significant effect on the apparent volumes of distribution or other pharmacokinetic parameters of sulfisoxazole and its N4-acetylsulfisoxazole metabolite."( Surgically affected sulfisoxazole pharmacokinetics in the morbidly obese.
Eberst, K; Garrett, ER; O'Leary, JP; Süverkrup, RS; Yost, RL, )		0.13

Bioavailability

ExcerptReferenceRelevance
" There was no significant variation between the two groups of volunteers in the absorption rate constant, Cmax, bioavailability, the fraction of the dose of sulfisoxazole excreted unchanged, the area under the plasma curve of the N4-acetyl conjugate formed, and in the apparent volume of distribution of the drug."( Pharmacokinetics of sulfisoxazole in young and elderly subjects.
Barbeau, G; Bélanger, PM; Boisvert, A, 1984)		0.27

Dosage Studied

ExcerptRelevanceReference
" Dosing of this drug on a mg kg-1 basis is contraindicated."( Surgically affected sulfisoxazole pharmacokinetics in the morbidly obese.
Eberst, K; Garrett, ER; O'Leary, JP; Süverkrup, RS; Yost, RL, )		0.13
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Endothelin-1 receptorRattus norvegicus (Norway rat)IC50 (µMol)13.00000.00001.774610.0000AID66057
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID66057Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
Discovery and structure-activity relationships of sulfonamide ETA-selective antagonists.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (3)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (66.67)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.41

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.41 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.41)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
sulfamethoxazole
Sulfamethoxazole: A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208). sulfamethoxazole : An isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position.		1.9810isoxazoles;
substituted aniline;
sulfonamide antibiotic;
sulfonamide		antibacterial agent;
antiinfective agent;
antimicrobial agent;
drug allergen;
EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
epitope;
P450 inhibitor;
xenobiotic
sulfathiazole
Sulfathiazole: A sulfathiazole compound that is used as a short-acting anti-infective agent. It is no longer commonly used systemically due to its toxicity, but may still be applied topically in combination with other drugs for the treatment of vaginal and skin infections, and is still used in veterinary medicine.. sulfathiazole : A 1,3-thiazole compound having a 4-aminobenzenesulfonamido group at the 2-position.		1.98101,3-thiazoles;
substituted aniline;
sulfonamide antibiotic;
sulfonamide		antiinfective agent;
drug allergen;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
xenobiotic
sulfisoxazole
Sulfisoxazole: A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.. sulfisoxazole : A sulfonamide antibacterial with an oxazole substituent. It has antibiotic activity against a wide range of gram-negative and gram-positive organisms.		2.6630isoxazoles;
sulfonamide antibiotic;
sulfonamide		antibacterial drug;
drug allergen
sulfatroxazole
sulfatroxazole: structure given in first source		1.9810
5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide
5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide: structure in first source; endothelin receptor antagonist		1.9810naphthalenes;
sulfonic acid derivative
ConditionIndicatedRelationship StrengthStudiesTrials
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.		01.9610