N(2)-(4-n-butylphenyl) 2'-deoxyguanosine: RN & structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
---|---|
PubMed CID | 135537671 |
CHEMBL ID | 2115349 |
MeSH ID | M0120234 |
Synonym |
---|
87781-96-2 |
6h-purin-6-one, 1,9-dihydro-2-((4-butylphenyl)amino)-9-(2-deoxy-beta-d-erythro-pentofuranosyl)- |
n(2)-(4-n-butylanilino)deoxyguanosine |
2'-deoxy-n(2)-(4-n-butylphenyl)guanosine |
1,9-dihydro-2-((4-butylphenyl)amino)-9-(2-deoxy-beta-d-erythro-pentofuranosyl)-6h-purin-6-one |
n(2)-(4-n-butylphenyl) 2'-deoxyguanosine |
CHEMBL2115349 , |
bdbm50405103 |
DTXSID40236624 |
Excerpt | Reference |
---|---|
" However, BuPGdR did not accumulate single strand breaks in cells irradiated with 5 J/m2 UV-light even at the highest dosage tested, indicating that BuPGdR does not inhibit DNA repair." | ( Involvement of DNA polymerase delta and/or epsilon in joining UV-induced DNA single strand breaks in human fibroblasts (comparison of effects of butylphenyldeoxyguanosine with aphidicolin). Itoh, R; Yamada, K, 1994) |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
DNA polymerase alpha catalytic subunit | Homo sapiens (human) | Ki | 20.4333 | 0.8300 | 1.5650 | 2.3000 | AID53664 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Thymidine kinase | Human alphaherpesvirus 1 strain SC16 | EC50 (µMol) | 25.0000 | 8.0000 | 8.0000 | 8.0000 | AID210529 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Process | via Protein(s) | Taxonomy |
---|---|---|
nucleotide binding | DNA polymerase alpha catalytic subunit | Homo sapiens (human) |
DNA binding | DNA polymerase alpha catalytic subunit | Homo sapiens (human) |
chromatin binding | DNA polymerase alpha catalytic subunit | Homo sapiens (human) |
DNA-directed DNA polymerase activity | DNA polymerase alpha catalytic subunit | Homo sapiens (human) |
protein binding | DNA polymerase alpha catalytic subunit | Homo sapiens (human) |
zinc ion binding | DNA polymerase alpha catalytic subunit | Homo sapiens (human) |
protein kinase binding | DNA polymerase alpha catalytic subunit | Homo sapiens (human) |
DNA replication origin binding | DNA polymerase alpha catalytic subunit | Homo sapiens (human) |
single-stranded DNA binding | DNA polymerase alpha catalytic subunit | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Process | via Protein(s) | Taxonomy |
---|---|---|
nucleus | DNA polymerase alpha catalytic subunit | Homo sapiens (human) |
nuclear envelope | DNA polymerase alpha catalytic subunit | Homo sapiens (human) |
nucleoplasm | DNA polymerase alpha catalytic subunit | Homo sapiens (human) |
alpha DNA polymerase:primase complex | DNA polymerase alpha catalytic subunit | Homo sapiens (human) |
nucleolus | DNA polymerase alpha catalytic subunit | Homo sapiens (human) |
cytosol | DNA polymerase alpha catalytic subunit | Homo sapiens (human) |
nuclear matrix | DNA polymerase alpha catalytic subunit | Homo sapiens (human) |
chromatin | DNA polymerase alpha catalytic subunit | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID53664 | Compound was tested for its inhibitory activity against HeLa DNA polymerase alpha, Ki values were obtained in the absence of dGTP | 1984 | Journal of medicinal chemistry, Feb, Volume: 27, Issue:2 | Synthesis and characterization of N2-(p-n-butylphenyl)-2'-deoxyguanosine and its 5'-triphosphate and their inhibition of HeLa DNA polymerase alpha. |
AID210529 | Inhibitory activity against Herpes simplex virus type-I specific thymidine kinase | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | N2-phenyldeoxyguanosine: a novel selective inhibitor of herpes simplex thymidine kinase. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 3 (50.00) | 18.7374 |
1990's | 3 (50.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 6 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |