Compounds > morphine 6-nicotinate
Page last updated: 2024-12-11

morphine 6-nicotinate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

morphine 6-nicotinate: RN given refers to (5alpha,6alpha)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5488579
MeSH IDM0100275

Synonyms (16)

Synonym
morphine 6-nicotinate
unii-819768139g
75533-60-7
6-nicotinoylmorphine
morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl-(5alpha,6alpha)-, 6-(3-pyridinecarboxylate)
819768139g ,
6-mononicotioylmorphine
morphin-6-nicotinat
J457.075H ,
6-mononicotinoylmorphine
morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5.alpha.,6.alpha.)-, 6-(3-pyridinecarboxylate)
morphine, 6-nicotinate
DTXSID00996994
3-hydroxy-17-methyl-7,8-didehydro-4,5-epoxymorphinan-6-yl pyridine-3-carboxylate
Q27269232
[(4r,4ar,7s,7ar,12bs)-9-hydroxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl] pyridine-3-carboxylate

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" The rate of absorption differs between patients and governs the overall pharmacokinetic profile of the compound."( Pharmacokinetics of intramuscular nicomorphine and its metabolites in man.
Booij, LH; Dirksen, R; Koopman-Kimenai, PM; Nijhuis, GM; Vree, TB, 1991)		0.28

Bioavailability

ExcerptReferenceRelevance
" The rate of absorption differs between patients and governs the overall pharmacokinetic profile of the compound."( Pharmacokinetics of intramuscular nicomorphine and its metabolites in man.
Booij, LH; Dirksen, R; Koopman-Kimenai, PM; Nijhuis, GM; Vree, TB, 1991)		0.28
"29), suggesting it is directly related to the absorption rate of nicomorphine."( The bioavailability of intramuscularly administered nicomorphine (Vilan) with its metabolites and their glucuronide conjugates in surgical patients.
Booij, LH; Dirksen, R; Koopman-Kimenai, PM; Vree, TB, 1995)		0.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (42.86)18.7374
1990's4 (57.14)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.21

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.21 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.21)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (28.57%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (71.43%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
bupivacaine
Bupivacaine: A widely used local anesthetic agent.. 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.. bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.		3.3711aromatic amide;
piperidinecarboxamide;
tertiary amino compound
thiopental
Thiopental: A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration.. thiopental : A barbiturate, the structure of which is that of 2-thiobarbituric acid substituted at C-5 by ethyl and sec-pentyl groups.		3.3711barbituratesanticonvulsant;
drug allergen;
environmental contaminant;
intravenous anaesthetic;
sedative;
xenobiotic
morphine
Meconium: The thick green-to-black mucilaginous material found in the intestines of a full-term fetus. It consists of secretions of the INTESTINAL GLANDS; BILE PIGMENTS; FATTY ACIDS; AMNIOTIC FLUID; and intrauterine debris. It constitutes the first stools passed by a newborn.		10.1762morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic
morphine-6-glucuronide
morphine-6-glucuronide: RN given refers to (5alpha,6alpha)-isomer		3.3711morphinane alkaloid
nicomorphine
nicomorphine: RN given refers to parent cpd		5.1762morphinane alkaloid
morphine-3-glucuronide
morphine-3-glucuronide: RN given refers to (5alpha,6alpha)-isomer		3.3711morphinane alkaloid
ConditionIndicatedRelationship StrengthStudiesTrials