Compounds > mf 5137
Page last updated: 2024-12-08

mf 5137

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID460150
CHEMBL ID124970
MeSH IDM0256734

Synonyms (12)

Synonym
6-amino-1-cyclopropyl-8-methyl-7-(1,2,3,4-tetrahydro-2-isoquinolinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
6-amino-1-cyclopropyl-7-(3,4-dihydro-1h-isoquinolin-2-yl)-8-methyl-4-oxo-quinoline-3-carboxylic acid
6-amino-1-cyclopropyl-7-(3,4-dihydro-1h-isoquinolin-2-yl)-8-methyl-4-oxoquinoline-3-carboxylic acid
CHEMBL124970 ,
148927-23-5
mf-5137
HY-100289
CS-0018441
mf 5137
mf5137
bdbm50470986
AKOS040733727
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (62)

Assay IDTitleYearJournalArticle
AID68193In vitro antibacterial activity against Enterobacter cloacae OMNFI 1741996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID96070Antibacterial activity tested against Klebsiella pneumoniae (Klebsiella pneumoniae) ATCC 100311996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID165040In vitro antibacterial activity against Pseudomonas aeruginosa ATC1C 90271996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID96251In vitro antibacterial activity against Klebsiella pneumoniae ATCC 100311996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID207330Antibacterial activity against Staphylococcus aureus MPR 51996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID209072Antibacterial activity tested against Streptococcus faecalis LEP Br1996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID205567Antibacterial activity tested against Staphylococcus epidermidis HCF Berset C1996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID69926Antibacterial activity tested against Escherichia coli ATCC 87391996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID484794Antibacterial activity against Staphylococcus aureus ATCC 25923 by microdilution technique2010Journal of medicinal chemistry, Jun-10, Volume: 53, Issue:11
From 6-aminoquinolone antibacterials to 6-amino-7-thiopyranopyridinylquinolone ethyl esters as inhibitors of Staphylococcus aureus multidrug efflux pumps.
AID163752Antibacterial activity tested against Providencia stuartii CNUR 51996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID484801Antibacterial activity against Staphylococcus aureus K1628 bearing S84L mutant GyrA and S80F mutant GrlA by microdilution technique2010Journal of medicinal chemistry, Jun-10, Volume: 53, Issue:11
From 6-aminoquinolone antibacterials to 6-amino-7-thiopyranopyridinylquinolone ethyl esters as inhibitors of Staphylococcus aureus multidrug efflux pumps.
AID85976In vitro antibacterial activity against Haemophilus influenzae1996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID68025Antibacterial activity tested against Enterobacter cloacae OMNFI 1741996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID15716CLogP was calculated1996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID228942Mean MIC against gram negative1996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID206294In vitro antibacterial activity against Staphylococcus aureus M-R POMM 62141996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID70937In vitro antibacterial activity against Escherichia coliCPX-R OBT 4311996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID210223In vitro antibacterial activity against Streptococcus pneumoniae I 0.431996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID207249Efficacy against Septicemia caused by Staphylococcus aureus in mice by Oral administration1996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID74726Geometric mean of antibacterial activity (Gram -ve bacteria) of the compound1996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID207329Antibacterial activity against Staphylococcus aureus ATCC 65381996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID228943Mean MIC against gram positive1996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID74852Geometric mean of antibacterial activity (Gram +ve bacteria) of the compound1996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID70917In vitro antibacterial activity against Escherichia coli 1201996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID81946In vitro toxicity to C8166 (human CD4) cells.2000Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20
6-Aminoquinolones as new potential anti-HIV agents.
AID207331Antibacterial activity tested against Staphylococcus aureus Methicillin-and Ciprofloxacin resistants; Range is 0.05-1 ug/mL1996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID78703Inhibitory effect against Escherichia coli Gyrase in Supercoiling assay1996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID42400Selectivity index in HIV-1 infected C8166 (human CD4) cells.2000Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20
6-Aminoquinolones as new potential anti-HIV agents.
AID206291In vitro antibacterial activity against Staphylococcus aureus CPX-R OBT 6871996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID164387Antibacterial activity tested against P. ae (Pseudomonas aeruginosa) ATCC 90271996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID165052In vitro antibacterial activity against Pseudomonas aeruginosa OBT 3071996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID162750In vitro antibacterial activity against Proteus mirabilis OBT 5051996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID15679Calculated partition coefficient (clogP)1996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID67245In vitro antibacterial activity against Enterococcus faecalis UCMC 396901996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID67058Antibacterial activity tested against Enterococcus faecalis1996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID484798Antibacterial activity against Staphylococcus aureus K1035 bearing wild-type GyrA and S80F mutant GrlA by microdilution technique2010Journal of medicinal chemistry, Jun-10, Volume: 53, Issue:11
From 6-aminoquinolone antibacterials to 6-amino-7-thiopyranopyridinylquinolone ethyl esters as inhibitors of Staphylococcus aureus multidrug efflux pumps.
AID484793Antibacterial activity against Escherichia coli ATCC 25922 by microdilution technique2010Journal of medicinal chemistry, Jun-10, Volume: 53, Issue:11
From 6-aminoquinolone antibacterials to 6-amino-7-thiopyranopyridinylquinolone ethyl esters as inhibitors of Staphylococcus aureus multidrug efflux pumps.
AID203049Antibacterial activity tested against Shigella enteritidis1996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID68212Antibacterial activity tested against Enterococcus faecium; Range is 0.06-1 ug/mL1996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID484791Antibacterial activity against Staphylococcus aureus SA-K1902 bearing norA- deficient mutation by microdilution technique2010Journal of medicinal chemistry, Jun-10, Volume: 53, Issue:11
From 6-aminoquinolone antibacterials to 6-amino-7-thiopyranopyridinylquinolone ethyl esters as inhibitors of Staphylococcus aureus multidrug efflux pumps.
AID70919In vitro antibacterial activity against Escherichia coli ATCC 259221996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID205566Antibacterial activity tested against Staphylococcus epidermidis CPHL A21996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID207251Minimum inhibitory concentration against Septicemia caused by Staphylococcus aureus in mice1996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID484797Antibacterial activity against Staphylococcus aureus SA-1199B norA++ and A116E GrlA mutation by microdilution technique2010Journal of medicinal chemistry, Jun-10, Volume: 53, Issue:11
From 6-aminoquinolone antibacterials to 6-amino-7-thiopyranopyridinylquinolone ethyl esters as inhibitors of Staphylococcus aureus multidrug efflux pumps.
AID484799Antibacterial activity against Staphylococcus aureus K1134 bearing wild-type GyrA and S80Y mutant GrlA by microdilution technique2010Journal of medicinal chemistry, Jun-10, Volume: 53, Issue:11
From 6-aminoquinolone antibacterials to 6-amino-7-thiopyranopyridinylquinolone ethyl esters as inhibitors of Staphylococcus aureus multidrug efflux pumps.
AID484795Antibacterial activity against Staphylococcus aureus SA-K1904 bearing norA++ efficient mutation by microdilution technique2010Journal of medicinal chemistry, Jun-10, Volume: 53, Issue:11
From 6-aminoquinolone antibacterials to 6-amino-7-thiopyranopyridinylquinolone ethyl esters as inhibitors of Staphylococcus aureus multidrug efflux pumps.
AID484796Antibacterial activity against wild-type norA expressing Staphylococcus aureus SA-1199 by microdilution technique2010Journal of medicinal chemistry, Jun-10, Volume: 53, Issue:11
From 6-aminoquinolone antibacterials to 6-amino-7-thiopyranopyridinylquinolone ethyl esters as inhibitors of Staphylococcus aureus multidrug efflux pumps.
AID163221Antibacterial activity tested against Proteus vulgaris CNUR 51996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID69927Antibacterial activity tested against Escherichia coli ISF 4321996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID67244In vitro antibacterial activity against Enterococcus faecalis LEP Br1996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID206289In vitro antibacterial activity against Staphylococcus aureus ATCC 292131996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID484800Antibacterial activity against Staphylococcus aureus K1305 bearing wild-type GyrA and E84K mutant GrlA by microdilution technique2010Journal of medicinal chemistry, Jun-10, Volume: 53, Issue:11
From 6-aminoquinolone antibacterials to 6-amino-7-thiopyranopyridinylquinolone ethyl esters as inhibitors of Staphylococcus aureus multidrug efflux pumps.
AID69137Inhibitory activity against gyrase supercoiling activity from Escherichia coli1996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID207250Efficacy against Septicemia caused by Staphylococcus aureus in mice by subcutaneous administration1996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID206295In vitro antibacterial activity against Staphylococcus aureus MPR 51996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID81099In vitro antiviral activity against HIV-1 IIIB in C8166 (human CD4) cells.2000Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20
6-Aminoquinolones as new potential anti-HIV agents.
AID209465In vitro antibacterial activity against Streptococcus pyogenes OMNFI BI1996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID207338Antibacterial activity tested against Staphylococcus aureus; Range is 0.004-0.03 ug/mL1996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID163242In vitro antibacterial activity against Proteus vulgaris CNUR 61996Journal of medicinal chemistry, Dec-06, Volume: 39, Issue:25
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.
AID210025Antibacterial activity tested against Streptococcus pneumoniae1996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
AID484802Antibacterial activity against Staphylococcus aureus K1640 bearing S84L mutant GyrA and S80Y mutant GrlA by microdilution technique2010Journal of medicinal chemistry, Jun-10, Volume: 53, Issue:11
From 6-aminoquinolone antibacterials to 6-amino-7-thiopyranopyridinylquinolone ethyl esters as inhibitors of Staphylococcus aureus multidrug efflux pumps.
AID484792Antibacterial activity against methicillin and ciprofloxacin-resistant Staphylococcus aureus 25A by microdilution technique2010Journal of medicinal chemistry, Jun-10, Volume: 53, Issue:11
From 6-aminoquinolone antibacterials to 6-amino-7-thiopyranopyridinylquinolone ethyl esters as inhibitors of Staphylococcus aureus multidrug efflux pumps.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (60.00)18.2507
2000's1 (20.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.40

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.40 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.20 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.40)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		3.150aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
reserpine
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.. reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.		2.0510alkaloid ester;
methyl ester;
yohimban alkaloid		adrenergic uptake inhibitor;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
first generation antipsychotic;
plant metabolite;
xenobiotic
carbostyril
Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.. quinolin-2(1H)-one : A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.		1.9810monohydroxyquinoline;
quinolone		bacterial xenobiotic metabolite
zidovudine
Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.		210azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
rufloxacin
rufloxacin: structure in first source		2.420fluoroquinolone antibiotic;
quinolines;
quinolone antibiotic
moxifloxacin
Moxifloxacin: A fluoroquinolone that acts as an inhibitor of DNA TOPOISOMERASE II and is used as a broad-spectrum antibacterial agent.. moxifloxacin : A quinolone that consists of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents.		2.0510aromatic ether;
cyclopropanes;
fluoroquinolone antibiotic;
pyrrolidinopiperidine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone		antibacterial drug
ConditionIndicatedRelationship StrengthStudiesTrials
Blood Poisoning
[description not available]		01.9910
Sepsis
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.		01.9910