Compounds > methylprednisolone sodium succinate
Page last updated: 2024-11-13

methylprednisolone sodium succinate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID23680530
CHEMBL ID1201081
CHEBI ID6890
SCHEMBL ID40947
MeSH IDM0013666

Synonyms (105)

Synonym
methylprednisolone sodium succinate
2375-03-3
methylprednisolone sodium hemisuccinate
solu-medrol
u 9088
urbason solubile
nsc-48989
solu-medrone
solumedrol
nsc48989
m-6-p
sodium 4-{[(6alpha,11beta)-11,17-dihydroxy-6-methyl-3,20-dioxopregna-1,4-dien-21-yl]oxy}-4-oxobutanoate
pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-6-alpha-methyl-, 21-(hydrogen succinate), monosodium salt
6alpha-methylprednisolone 21-sodium hemisuccinate
einecs 219-156-8
sodium methylprednisolone succinate
ubrason solubile [inj.]
pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, monosodium salt, (6alpha,11beta)-
metypred
6alpha-methylprednisolone 21-hemisuccinate sodium salt
6-alpha-methylprednisolone sodium succinate
prednilem
cryosolona [inj.]
11-beta,17,21-trihydroxy-6-alpha-methyl-1,4-pregnadiene-3,20-dione 21-(sodium succinate)
11beta,17,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-(sodium succinate)
metypresol
6alpha-methylpregnisolone 21-sodium succinate
firmacort fiale
medrate [inj.]
pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl-, 21-(hydrogen succinate), monosodium salt
methylprednisolone succinate sodium salt
metypred [inj.]
6alpha-methylprednisolone 21-sodium succinate
nsc 48989
sol melcort
lemod solu
pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-6-alpha-methyl-, 21- (hydrogen succinate), monosodium salt
6alpha-methylprednisolone sodium hemisuccinate
prednisolone, 6alpha-methyl-, succinate, sodium salt
prednol [inj.]
succinic acid, 21-monoester with 11beta,17,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione, monosodium salt
asmacortone
corticel
nirypan solubile
6alpha-methylprednisolone sodium succinate
methylprednisolone sodium succinate (jan/usp)
solu-medrol (tn)
D00751
a-methapred (tn)
sodium succinate, methylprednisolone
methylprednisolone 21-succinate sodium salt
CHEMBL1201081
solu medrol
ubrason solubile
lec9gky20k ,
omnacortil
cryosolona
unii-lec9gky20k
methylprednisolone sodium succinate [usp:jan]
prednol
dtxsid2023303 ,
cas-2375-03-3
tox21_113527
dtxcid103303
AKOS015962276
methylprednisolone sodium succinate [usp impurity]
methylprednisolone sodium succinate [usp monograph]
methylprednisolone sodium succinate [who-dd]
methylprednisolone sodium succinate [mart.]
methylprednisolone sodium succinate [orange book]
methylprednisolone 21-succinate sodium salt [mi]
methylprednisolone sodium succinate [jan]
methylprednisolone sodium succinate [vandf]
pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, monosodium salt, (6.alpha.,11.beta.)-
SCHEMBL40947
CS-4582
W-107376
6a-methylprednisolone 21-succinate sodium
HY-B1060
6|a-methylprednisolone 21-hemisuccinate (sodium salt)
6afae'a centa' nota inverted exclamation markafasa'a|afae'adaggeratrade mark?-methylprednisolone 21-hemisuccinate (sodium salt)
methylprodnisolone sodium succinate
6-methylprednisolone succinate sodium
AS-74917
sodium 4-{2-[(1r,3as,3bs,5s,9ar,9bs,10s,11as)-1,10-dihydroxy-5,9a,11a-trimethyl-7-oxo-1h,2h,3h,3ah,3bh,4h,5h,7h,9ah,9bh,10h,11h,11ah-cyclopenta[a]phenanthren-1-yl]-2-oxoethoxy}-4-oxobutanoate
methylprednisolone hydrogen succinate sodium salt
CHEBI:6890
FQISKWAFAHGMGT-SGJOWKDISA-M
methylprednisolone sodium succinate;6-methylprednisolone succinate sodium
Q27282942
D95085
6-methylprednisolone 21-hemisuccinate (sodium salt)
sodium;4-[2-[(6s,8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoate
ubrason solubile (inj.)
11beta,17,21-trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione 21-sodium succinate
medrate (inj.)
methylprednisolone sodium succinate (mart.)
solu-medrol(r) methylprednisolone sodium succinat
solu moderin
methylprednisolone sodium succinate (usp monograph)
prednol (inj.)
methylprednisolone sodium succinate (usp:jan)
metypred (inj.)
cryosolona (inj.)
methylprednisolone sodium succinate (usp impurity)

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)		0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
corticosteroid hormoneAny of a class of steroid hormones that are produced in the adrenal cortex.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
TDP1 proteinHomo sapiens (human)Potency3.75860.000811.382244.6684AID686979
AR proteinHomo sapiens (human)Potency0.16820.000221.22318,912.5098AID743035; AID743036; AID743040; AID743042; AID743053; AID743054; AID743063
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency0.07390.000214.376460.0339AID720691; AID720692; AID720719
estrogen nuclear receptor alphaHomo sapiens (human)Potency6.39670.000229.305416,493.5996AID743069; AID743080; AID743091
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency0.04730.001723.839378.1014AID743083
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID180509Tested in vitro for the inhibition of iron-dependent lipid peroxidation against rat brain homogenates, by malondialdehyde (MDA) formation assay1992Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23
2-(Aminomethyl)chromans that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma and ischemia.
AID130844Percent increase in KCN lethality (cytotoxic hypoxia) model against male CF-1 mice at a dose 100 mg/kg administered intravenously1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Novel 21-aminosteroids that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma.
AID130086Evaluated for in vivo neuroprotective activity in a mouse head injury model expressed as 1 hr post injury grip scores1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Novel 21-aminosteroids that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma.
AID182836Ability to inhibit iron-dependent lipid peroxidation in rat brain homogenate using MDA (malondialdehyde) formation assay at 300 uM1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Novel 21-aminosteroids that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma.
AID139247Lowest effective dosage in Mouse Head Injury Assay.1992Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23
2-(Aminomethyl)chromans that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma and ischemia.
AID131976Tested in vivo for neuroprotectant activity against mouse head injury(MHI) model.1992Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23
2-(Aminomethyl)chromans that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma and ischemia.
AID130845Percent increase in KCN lethality (cytotoxic hypoxia) model against male CF-1 mice at a dose 30 mg/kg administered intravenously1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Novel 21-aminosteroids that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma.
AID135622Lowest effective dose in a mouse head injury model was reported1990Journal of medicinal chemistry, Apr, Volume: 33, Issue:4
Novel 21-aminosteroids that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's2 (40.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 60.04

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index60.04 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index92.95 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (60.04)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
deferoxamine
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.. desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.		1.9710acyclic desferrioxaminebacterial metabolite;
ferroptosis inhibitor;
iron chelator;
siderophore
d-alpha tocopherol
Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.		2.3820alpha-tocopherolalgal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
[no description available]		1.9810chromanol;
monocarboxylic acid;
phenols		antioxidant;
ferroptosis inhibitor;
neuroprotective agent;
radical scavenger;
Wnt signalling inhibitor
u 78517f
U 78517F: iron-catalyzed lipid peroxidation inhibitor; structure given in first source; RN given is for diHCl		1.9810
ConditionIndicatedRelationship StrengthStudiesTrials
Cerebral Ischemia
[description not available]		01.9810
Injuries
Used with anatomic headings, animals, and sports for wounds and injuries. Excludes cell damage, for which pathology is used.		01.9810
Brain Ischemia
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.		01.9810
Wounds and Injuries
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.		01.9810
Craniocerebral Injuries
[description not available]		01.9710
Injuries, Spinal
[description not available]		01.9710
Craniocerebral Trauma
Traumatic injuries involving the cranium and intracranial structures (i.e., BRAIN; CRANIAL NERVES; MENINGES; and other structures). Injuries may be classified by whether or not the skull is penetrated (i.e., penetrating vs. nonpenetrating) or whether there is an associated hemorrhage.		01.9710