methyldeoxyspergualin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

15-deoxymethylspergualin: act on the proliferation & differentiation of T cells which respond to growth factors, such as IL-2 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	126996
CHEMBL ID	1771562
SCHEMBL ID	9772181
MeSH ID	M0206705

Synonyms (19)

Synonym
15-deoxy-11-o-methylspergualin
114760-35-9
heptanamide, 7-((aminoiminomethyl)amino)-n-(2-((4-((3-amino propyl)amino)butyl)amino)-1-methoxy-2-oxoethyl)-, (s)-
(-)-15-deoxy-11-o-methylspergualin
medsg
deoxymethylspergualin
methyldeoxyspergualin
15-medsg
15-deoxymethylspergualin
heptanamide, 7-((aminoiminomethyl)amino)-n-(2-((4-((3-aminopropyl)amino)butyl)amino)-1-methoxy-2-oxoethyl)-
deoxymethyspergualin
1-amino-19-guanidino-11-methoxy-4,9,12-triazanonadecane-10,13-dione
98629-44-8
CHEMBL1771562
n-[4-(3-aminopropyl)aminobutyl]-2-(7-guanidinoheptanamido)-2-methoxyethanamide
HFNDGMJKLKYYRZ-UHFFFAOYSA-N
SCHEMBL9772181
DTXSID90913155
n-[2-({4-[(3-aminopropyl)amino]butyl}imino)-2-hydroxy-1-methoxyethyl]-7-carbamimidamidoheptanimidic acid

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (7)

Assay ID	Title	Year	Journal	Article
AID595073	Chemical stability of the compound in aqueous buffer assessed as half life at pH 7 by thin layer chromatography	2011	Bioorganic & medicinal chemistry letters, May-01, Volume: 21, Issue:9	Improved synthesis of 15-deoxyspergualin analogs using the Ugi multi-component reaction.
AID595046	Chemical stability of the compound in aqueous buffer assessed as half life at pH 8 by thin layer chromatography	2011	Bioorganic & medicinal chemistry letters, May-01, Volume: 21, Issue:9	Improved synthesis of 15-deoxyspergualin analogs using the Ugi multi-component reaction.
AID595048	Antibacterial activity against Escherichia coli	2011	Bioorganic & medicinal chemistry letters, May-01, Volume: 21, Issue:9	Improved synthesis of 15-deoxyspergualin analogs using the Ugi multi-component reaction.
AID595049	Antibacterial activity against Bacillus subtilis	2011	Bioorganic & medicinal chemistry letters, May-01, Volume: 21, Issue:9	Improved synthesis of 15-deoxyspergualin analogs using the Ugi multi-component reaction.
AID595047	Chemical stability of the compound in aqueous buffer assessed as half life at pH 10 by thin layer chromatography	2011	Bioorganic & medicinal chemistry letters, May-01, Volume: 21, Issue:9	Improved synthesis of 15-deoxyspergualin analogs using the Ugi multi-component reaction.
AID595072	Chemical stability of the compound in aqueous buffer assessed as half life at pH 5 by thin layer chromatography	2011	Bioorganic & medicinal chemistry letters, May-01, Volume: 21, Issue:9	Improved synthesis of 15-deoxyspergualin analogs using the Ugi multi-component reaction.
AID595050	Antibacterial activity against Staphylococcus aureus	2011	Bioorganic & medicinal chemistry letters, May-01, Volume: 21, Issue:9	Improved synthesis of 15-deoxyspergualin analogs using the Ugi multi-component reaction.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (29)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (17.24)	18.7374
1990's	19 (65.52)	18.2507
2000's	3 (10.34)	29.6817
2010's	2 (6.90)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.41

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.41 (24.57)
Research Supply Index	3.40 (2.92)
Research Growth Index	4.81 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.41)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	29 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
lactic acid Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.	2	1	2-hydroxy monocarboxylic acid	algal metabolite; Daphnia magna metabolite
putrescine [no description available]	2.01	1	alkane-alpha,omega-diamine	antioxidant; fundamental metabolite
spermidine [no description available]	2.01	1	polyazaalkane; triamine	autophagy inducer; fundamental metabolite; geroprotector
azathioprine Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed). azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.	2.39	2	aryl sulfide; C-nitro compound; imidazoles; thiopurine	antimetabolite; antineoplastic agent; carcinogenic agent; DNA synthesis inhibitor; hepatotoxic agent; immunosuppressive agent; prodrug
lysine Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.	2.01	1	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
methylprednisolone Methylprednisolone: A PREDNISOLONE derivative with similar anti-inflammatory action.. 6alpha-methylprednisolone : The 6alpha-stereoisomer of 6-methylprednisolone.	2	1	6-methylprednisolone; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	adrenergic agent; anti-inflammatory drug; antiemetic; environmental contaminant; neuroprotective agent; xenobiotic
gusperimus gusperimus: synthesized by chemical modification of spergualin; in combination with cyclosporin A prevents diabetes in predisposed NOD mice; structure given in first source; RN given refers to (-)-isomer trihydrochloride	3.77	11	N-acyl-amino acid
hypusine hypusine: N-terminal amino alcohol deriv of Lys occurring in bovine brain & in the urine of children with familial hyperlysinemia; minor descriptor (75-82); online & Index Medicus search LYSINE/AA (75-82). hypusine : An L-lysine derivative that is L-lysine bearing a (2R)-4-amino-2-hydroxybutyl substituent at position N(6).	2.01	1
mizoribine [no description available]	1.97	1	imidazoles	anticoronaviral agent
tacrolimus Tacrolimus: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.. tacrolimus (anhydrous) : A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.	3.08	5	macrolide lactam	bacterial metabolite; immunosuppressive agent
mycophenolic acid Mycophenolic Acid: Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.. mycophenolate : A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of mycophenolic acid.. mycophenolic acid : A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.	2	1	2-benzofurans; gamma-lactone; monocarboxylic acid; phenols	anticoronaviral agent; antimicrobial agent; antineoplastic agent; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; environmental contaminant; immunosuppressive agent; mycotoxin; Penicillium metabolite; xenobiotic
sirolimus Sirolimus: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.. sirolimus : A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.	2	1	antibiotic antifungal drug; cyclic acetal; cyclic ketone; ether; macrolide lactam; organic heterotricyclic compound; secondary alcohol	antibacterial drug; anticoronaviral agent; antineoplastic agent; bacterial metabolite; geroprotector; immunosuppressive agent; mTOR inhibitor
spergualin spergualin: from bacillus isolated from soil sample collected at Ohira-san	2.38	2	N-acyl-amino acid
cyclosporine Cyclosporine: A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).	2.9	4
concanavalin a Concanavalin A: A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.	1.97	1

Condition	Relationship Strength	Studies
Autoimmune Diabetes [description not available]	2	1
Diabetes Mellitus, Type 1 A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.	2	1
Osteogenic Sarcoma [description not available]	2	1
Osteosarcoma A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)	2	1
Leukemia L 1210 [description not available]	1.97	1

chemdatabank.com