methylarginyl-lysyl-prolyl-tryptophyl-tert-leucyl-leucyl-ethyl ester: hexapeptide with neurotensin activity [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 130482 |
| MeSH ID | M0186611 |
| Synonym |
|---|
| methylarginyl-lysyl-prolyl-tryptophyl-tert-leucyl-leucyl-ethyl ester |
| 125600-60-4 |
| h(ch3)-arg-lys-pro-trp-tert-leu-leu-oet |
| (me)arg-lys-pro-trp-tert-leu-leu-oet |
| l-leucine, n-(3-methyl-n-(n-(1-(n2-(n2-methyl-l-arginyl)-l-lysyl)-l-prolyl)-l-tryptophyl)-l-valyl)-, ethyl ester |
| nt-1 |
| (methyl)-arginyl-lysyl-prolyl-tryptophyl-tert-leucyl-leucine ethyl ester |
| ethyl (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-1-[(2s)-6-amino-2-[[(2s)-5-(diaminomethylideneamino)-2-methylaminopentanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1h-indol-3-yl)propanoyl]amino]-3,3-dimethylbutanoyl]amino]-4-methylpentanoate |
| eisai-1 |
| gtpl1566 |
| malptll |
| ethyl (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-1-[(2s)-6-amino-2-[[(2s)-5-(diaminomethylideneamino)-2-(methylamino)pentanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1h-indol-3-yl)propanoyl]amino]-3,3-dimethylbutanoyl]amino]-4-methylpentanoate |
| 1-{n~2~-[5-carbamimidamido-1-hydroxy-2-(methylamino)pentylidene]lysyl}-n-[1-({1-[(1-ethoxy-4-methyl-1-oxopentan-2-yl)imino]-1-hydroxy-3,3-dimethylbutan-2-yl}imino)-1-hydroxy-3-(1h-indol-3-yl)propan-2-yl]pyrrolidine-2-carboximidic acid |
| DTXSID20925185 |
| Q27077168 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "A high-performance liquid chromatographic method to determine (Me)Arg-Lys-Pro-Trp-tert-Leu-Leu (NT-2) with neurotensin (NT) activity in rat plasma was developed and a pharmacokinetic study was performed in rats." | ( Pharmacokinetics of novel hexapeptides with neurotensin activity in rats. Abe, K; Machida, R; Sasaki, A; Tokumura, T; Tsuchiya, Y, 1993) | 0.29 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1346391 | Rat NTS1 receptor (Neurotensin receptors) | 2003 | Molecular pharmacology, Aug, Volume: 64, Issue:2 | Differential involvement of intracellular domains of the rat NTS1 neurotensin receptor in coupling to G proteins: a molecular basis for agonist-directed trafficking of receptor stimulus. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (75.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.02) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||