Page last updated: 2024-12-06

methyl vinyl sulfone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Methyl vinyl sulfone (MVS) is a versatile reagent used in organic synthesis. It is a highly reactive electrophile that can undergo a variety of reactions, including Michael additions, Diels-Alder reactions, and nucleophilic substitutions. MVS is typically synthesized by the reaction of vinyl magnesium bromide with sulfur dioxide followed by methylation. It has been used in the synthesis of a wide range of compounds, including pharmaceuticals, agrochemicals, and materials. MVS is also a useful reagent for the modification of biomolecules, such as proteins and peptides. The reactivity of MVS stems from the electron-withdrawing nature of the sulfone group, which makes the vinyl group highly electrophilic. MVS has been studied for its potential applications in various fields, including organic synthesis, materials science, and medicinal chemistry.'

Cross-References

ID SourceID
PubMed CID19354
CHEMBL ID163849
SCHEMBL ID29683
MeSH IDM0169026

Synonyms (52)

Synonym
methyl vinyl sulphone
sulfone, methyl vinyl
nsc-518304
nsc518304
ethene, (methylsulfonyl)-
methyl vinyl sulfone
uri 718
wln: ws1&1u1
3680-02-2
methyl vinyl sulfphone
brn 0878198
nsc 518304
(methylsulphonyl)ethylene
ccris 4130
einecs 222-958-0
inchi=1/c3h6o2s/c1-3-6(2,4)5/h3h,1h2,2h
methyl vinyl sulfone, >=97%
(methylsulfonyl)ethene
1-methylsulfonylethene
methanesulfonyl-ethene
CHEMBL163849
AKOS009157720
methanesulfonylethene
EN300-50841
t6n4pu5bsh ,
unii-t6n4pu5bsh
1-(methylsulfonyl)ethylene
methylvinyl sulfone
methyl vinylsulfone
vinyl methylsulfone
methyl vinylsulphone
methylsulphonylethene
methyl-sulfonylethene
vinylmethylsulfone
methansulfonyl-ethene
methylvinyl sulphone
methylsulfonylethene
methylvinylsulphone
ethenyl methyl sulfone
vinyl methyl sulfone
methylvinylsulfone
SCHEMBL29683
1-(methylsulfonyl)ethylene #
mfcd00007567
F8880-3441
DTXSID1031628
Q1815264
D95725
(methylsulfonyl)ethylene
CS-0132320
uri-718
Z608051272
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID89966In vitro inhibition of inducible vascular cell adhesion molecule-1 (VCAM-1) expression in Human aortic endothelial cells (HAEC)2003Bioorganic & medicinal chemistry letters, Feb-24, Volume: 13, Issue:4
Lead discovery of alpha,beta-unsaturated sulfones from a combinatorial library as inhibitors of inducible VCAM-1 expression.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (11.11)18.7374
1990's3 (33.33)18.2507
2000's3 (33.33)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.92

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.92 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.73 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.92)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]