Page last updated: 2024-12-09

methyl isoquinoline-3-carboxylate

Cross-References

ID SourceID
PubMed CID725374
CHEMBL ID416152
CHEMBL ID-416152
CHEBI ID183729
SCHEMBL ID214090

Synonyms (37)

Synonym
AC-7697
SDCCGMLS-0065873.P001
SR-01000640142-1
methyl 3-isoquinolinecarboxylate, 98%
MAYBRIDGE1_001945
methyl isoquinoline-3-carboxylate
27104-73-0
HMS547A09
CHEMBL416152
isoquinoline-3-carboxylic acid methyl ester
CHEBI:183729
A5289
methyl 3-isoquinolinecarboxylate
CCG-50796
FT-0628748
PS-4179
AM20051023
AKOS015851535
SCHEMBL214090
3-isoquinolinecarboxylic acid methyl ester
ZBCGBIZQNMVMPC-UHFFFAOYSA-N
3-isoquinolinecarboxylic acid, methyl ester
J-200107
mfcd00075138
DTXSID10352385
methyl isoquinoline-3-carbo-xylate
BCP05782
SY018429
STL560143
CS-W016858
BBL037033
bis(2-pyrrolidinoethyl)ether
unii-eqt2546qnr
chembl-416152
eqt2546qnr ,
methyl-3-isoquinolinecarboxylate
PD185896
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
isoquinolinesA class of organic heteropolycyclic compound consisting of isoquinoline and its substitution derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (16)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)IC50 (µMol)13.20000.00010.507510.0000AID40832
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Ki13.20000.00020.656110.0000AID40666; AID40971
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)IC50 (µMol)13.20000.00010.507510.0000AID40832
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Ki13.20000.00020.656110.0000AID40666; AID40971
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)IC50 (µMol)13.20000.00010.507510.0000AID40832
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Ki13.20000.00020.656110.0000AID40666; AID40971
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)IC50 (µMol)13.20000.00010.505710.0000AID40832
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Ki13.20000.00020.561410.0000AID40666; AID40971
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)IC50 (µMol)13.20000.00010.497310.0000AID40832
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Ki13.20000.00020.635210.0000AID40666; AID40971
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)IC50 (µMol)13.20000.00010.507510.0000AID40832
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Ki13.20000.00020.621710.0000AID40666; AID40971
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)IC50 (µMol)13.20000.00010.498810.0000AID40832
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Ki13.20000.00020.675810.0000AID40666; AID40971
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)IC50 (µMol)13.20000.00010.504610.0000AID40832
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Ki13.20000.00020.646910.0000AID40666; AID40971
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)IC50 (µMol)13.20000.00010.507510.0000AID40832
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Ki13.20000.00020.656110.0000AID40666; AID40971
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)IC50 (µMol)13.20000.00010.507510.0000AID40832
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Ki13.20000.00020.656110.0000AID40666; AID40971
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)IC50 (µMol)13.20000.00010.507510.0000AID40832
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Ki13.20000.00020.671210.0000AID40666; AID40971
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)IC50 (µMol)13.20000.00010.506510.0000AID40832
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Ki13.20000.00020.557710.0000AID40666; AID40971
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)IC50 (µMol)13.20000.00010.505710.0000AID40832
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Ki13.20000.00020.640310.0000AID40666; AID40971
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)IC50 (µMol)13.20000.00010.507510.0000AID40832
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Ki13.20000.00020.570810.0000AID40666; AID40971
GABA theta subunitRattus norvegicus (Norway rat)IC50 (µMol)13.20000.00010.507510.0000AID40832
GABA theta subunitRattus norvegicus (Norway rat)Ki13.20000.00020.656110.0000AID40666; AID40971
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)IC50 (µMol)13.20000.00010.507510.0000AID40832
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Ki13.20000.00020.656110.0000AID40666; AID40971
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membraneGamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)
plasma membraneGamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)
plasma membraneGamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID40832In vitro inhibition of binding to the benzodiazepine receptor in rat cerebral cortical membrane using [3H]diazepam as radioligand1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore.
AID40971In vitro inhibition of [3H]diazepam binding to rat cerebral cortical membrane benzodiazepine receptors1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
Biomimetic approach to potential benzodiazepine receptor agonists and antagonists.
AID40666In vitro inhibition of [3H]diazepam binding to benzodiazepine receptor in rat cerebral cortical membrane1982Journal of medicinal chemistry, Sep, Volume: 25, Issue:9
Beta-carbolines: synthesis and neurochemical and pharmacological actions on brain benzodiazepine receptors.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (50.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (33.33)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.38 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.38)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
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