Compounds > methyl 5-nitro-2-furoate
Page last updated: 2024-12-07

methyl 5-nitro-2-furoate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID94882
CHEMBL ID120921
CHEBI ID189109
SCHEMBL ID1350315
MeSH IDM0110529

Synonyms (51)

Synonym
1874-23-3
nsc-6457
nsc6457
2-furancarboxylic acid, 5-nitro-, methyl ester
5-nitro-2-furoic acid methyl ester
methyl 5-nitropyromucate
brn 0165132
methyl 5-nitrofuroate
2-furoic acid, 5-nitro-, methyl ester
nsc 6457
ai3-23607
ccris 2152
methyl nitrofuroate
methyl 5-nitro-2-furancarboxylate
methyl 5-nitro-2-furoate
5-nitro-2-furancarboxylic acid methyl ester
STK448639
methyl 5-nitrofuran-2-carboxylate
methyl 5-nitro-2-furoate, 98%
SR-01000640475-1
AKOS003309694
CHEMBL120921
methyl 5-nitrouran-2-carboxylate
CHEBI:189109
EN300-49149
A813151
71qm4e6j90 ,
unii-71qm4e6j90
CCG-51159
GEO-01894
FT-0628326
5-nitro-2-(methoxycarbonyl)furan
methyl 5'-nitropyromucate
methyl 5-nitro-2-furylcarboxylate
SCHEMBL1350315
8P-568S
methyl 5 nitrofuran-2-carboxylate
methyl-5-nitrofuran-2-carboxylate
methyl-5-nitro-2-furoate
W-200187
DTXSID50172049
F8880-1591
mfcd00051956
Z19638744
CS-0048963
AM10047
SB13378
Q27265985
5-nitro-2-furan-carboxylic acid, methyl ester
methyl5-nitrofuran-2-carboxylate
SY041932
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
carboxylic esterAn ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
AID723483Cytotoxicity against human HeLa cells after 65 hrs by Alamar blue assay2013Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3
A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro.
AID106021Tested for cytotoxicity towards human MRC-5 cells2002Bioorganic & medicinal chemistry letters, Dec-16, Volume: 12, Issue:24
Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides.
AID213632Evaluated in vitro for antitrypanosomal activity against Trypanosoma cruzi2002Bioorganic & medicinal chemistry letters, Dec-16, Volume: 12, Issue:24
Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides.
AID100887Evaluated in vitro for antitrypanosomal activity against Leishmania infantum2002Bioorganic & medicinal chemistry letters, Dec-16, Volume: 12, Issue:24
Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides.
AID723484Trypanocidal activity against bloodstream form of Trypanosoma brucei brucei 427 after 72 hrs by Alamar blue assay2013Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3
A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro.
AID140480Tested for cytotoxicity towards mouse peritoneal macrophages (MPM)2002Bioorganic & medicinal chemistry letters, Dec-16, Volume: 12, Issue:24
Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides.
AID215328Evaluated in vitro for antitrypanosomal activity against Trypanosoma brucei2002Bioorganic & medicinal chemistry letters, Dec-16, Volume: 12, Issue:24
Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (28.57)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's3 (42.86)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.72 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pentamidine
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.		2.0810aromatic ether;
carboxamidine;
diether		anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic
melarsoprol
Melarsoprol: Arsenical used in trypanosomiases. It may cause fatal encephalopathy and other undesirable side effects.		2.4420triazines
5-nitro-2-furoic acid
5-nitro-2-furoic acid: structure given in first source		2.0110
benzonidazole
benzonidazole: used in treatment of Chagas' disease. benznidazole : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease.		2.0110C-nitro compound;
imidazoles;
monocarboxylic acid amide		antiprotozoal drug
dinoprost
Dinoprost: A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.. prostaglandin F2alpha : A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor.		1.9610monocarboxylic acid;
prostaglandins Falpha		human metabolite;
mouse metabolite
15-keto-13,14-dihydroprostaglandin f2alpha
15-keto-13,14-dihydroprostaglandin F2alpha: main metabolite of PGF2alpha in plasma after allergen provoked asthma; RN given refers to (5Z,9alpha,11alpha)-isomer; structure. 13,14-dihydro-15-keto-PGF2alpha : A prostaglandin Falpha obtained by formal oxidation of the 15-hydroxy group and hydrogenation of the 13,14-double bond of prostaglandin F2alpha.		1.9610ketone;
prostaglandins Falpha		metabolite
nifurtimox
Nifurtimox: A nitrofuran thiazine that has been used against TRYPANOSOMIASIS.		2.4420nitrofuran antibiotic
allopurinol
Allopurinol: A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.. allopurinol : A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring.		1.9610nucleobase analogue;
organic heterobicyclic compound		antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger
ConditionIndicatedRelationship StrengthStudiesTrials
Plasmodium falciparum Malaria
[description not available]		02.110
Malaria, Falciparum
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.		02.110
Anemia, Fanconi
[description not available]		02.1310
Fanconi Anemia
Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)		02.1310