Page last updated: 2024-10-15

methisosildenafil

Description

methisosildenafil: synthetic analog in which the N-methylpiperazine moiety has been replaced with 2,6-dimethylpiperazine; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID135452876
SCHEMBL ID6497379
SCHEMBL ID18073972
MeSH IDM0510538

Synonyms (15)

Synonym
496835-35-9
aildenafil
dimethyl sildenafil
9t49w8gax6 ,
unii-9t49w8gax6
methisosildenafil
7h-pyrazolo(4,3-d)pyrimidin-7-one, 5-(5-(((3r,5s)-3,5-dimethyl-1-piperazinyl)sulfonyl)-2-ethoxyphenyl)-1,6-dihydro-1-methyl-3-propyl-, rel-
SCHEMBL6497379
DTXSID10197970
SCHEMBL18073972
Q15410232
BCP28111
aildenafil; dimethyl sildenafil; dimethylsildenafil
5-[5-[(3s,5r)-3,5-dimethylpiperazin-1-yl]sulfonyl-2-ethoxyphenyl]-1-methyl-3-propyl-6h-pyrazolo[4,3-d]pyrimidin-7-one
5-[5-[(3s,5r)-3,5-dimethylpiperazin-1-yl]sulfonyl-2-ethoxyphenyl]-1-methyl-3-propyl-4h-pyrazolo[4,3-d]pyrimidin-7-one

Pharmacokinetics

ExcerptReference
" This method has been used in a pharmacokinetic study of aildenafil in healthy male volunteers each given an oral administration of one of the three dosages."( Liquid chromatography tandem mass spectrometry assay to determine the pharmacokinetics of aildenafil in human plasma.
Cui, Y; Gu, J; Jiang, Y; Wang, J; Wang, Y; Zhao, X, 2007
)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (27.27)29.6817
2010's8 (72.73)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (9.09%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (90.91%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
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