methionylmethionine profile

Methionylmethionine (Met-Met) is a dipeptide consisting of two methionine amino acids linked by a peptide bond. It is a naturally occurring compound found in various biological systems and has been studied for its potential therapeutic applications. Met-Met is known to be a precursor for the biosynthesis of methionine, an essential amino acid required for protein synthesis and other metabolic processes. In addition to its role in protein synthesis, Met-Met has been implicated in various biological functions, including antioxidant activity, neuroprotection, and anti-inflammatory effects. Its antioxidant properties are attributed to its ability to scavenge free radicals, while its neuroprotective effects may be related to its ability to protect neurons from damage caused by oxidative stress. Met-Met is also being investigated for its potential therapeutic benefits in conditions such as Parkinson's disease, Alzheimer's disease, and cancer. However, further research is needed to fully understand the mechanisms of action and potential therapeutic applications of Met-Met.'

methionylmethionine: has growth-promoting ability equal to DL-methionine; RN given refers to (DL-Met-DL-Met)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Met-Met : A dipeptide formed from two L-methionine residues. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	104294
CHEMBL ID	159019
SCHEMBL ID	1157690
MeSH ID	M0106909

Synonym
met-met
nsc-522615
l-methionine, n-l-methionyl-
methionylmethionine
nsc522615
nsc-522618
nsc522618
chembl159019
2-(2-amino-4-methylsulfanyl-butyrylamino)-4-methylsulfanyl-butyric acid
bdbm50085087
2-[(2-amino-4-methylsulfanylbutanoyl)amino]-4-methylsulfanylbutanoic acid
einecs 258-124-8
methionine, methionyl-
52715-93-2
n-dl-methionyl-dl-methionine
SCHEMBL1157690
h-dl-met-dl-met-oh
ZYTPOUNUXRBYGW-UHFFFAOYSA-N
methionine-methionine dipeptide
m-m dipeptide
methionine methionine dipeptide
mm dipeptide
FT-0771536
2-(2-amino-4-(methylthio)butanamido)-4-(methylthio)butanoic acid
dl-methionyl-dl-methionine
F84478
DTXSID50886013

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (27.27)	18.7374
1990's	1 (9.09)	18.2507
2000's	1 (9.09)	29.6817
2010's	5 (45.45)	24.3611
2020's	1 (9.09)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
hydrogen sulfide Hydrogen Sulfide: A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed). hydrogen sulfide : A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.. thiol : An organosulfur compound in which a thiol group, -SH, is attached to a carbon atom of any aliphatic or aromatic moiety.	1.98	1	gas molecular entity; hydracid; mononuclear parent hydride; sulfur hydride	Escherichia coli metabolite; genotoxin; metabolite; signalling molecule; toxin; vasodilator agent
methylmercaptan methylmercaptan: intermediate in the manufacturing of jet fuels, pesticides, fungicides, plastics, synthesis of methionine; odor may cause nausea; narcotic in high concentrations; depresses urea biosynthesis; RN given refers to parent cpd; structure	1.98	1	alkanethiol	human metabolite; Saccharomyces cerevisiae metabolite
hydroxide ion [no description available]	1.96	1	oxygen hydride	mouse metabolite
methionine Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.	3.39	7	aspartate family amino acid; L-alpha-amino acid; methionine zwitterion; methionine; proteinogenic amino acid	antidote to paracetamol poisoning; human metabolite; micronutrient; mouse metabolite; nutraceutical
phenylalanylphenylalanine phenylalanylphenylalanine: RN given refers to (L,L)-isomer	2.13	1
phenylalanylleucine phenylalanylleucine: RN given refers to (L)-isomer	2.13	1	dipeptide zwitterion; dipeptide	plant metabolite
leucylleucine leucylleucine: RN given refers to (DL-Leu-DL-Leu)-isomer	2.13	1	peptide
valylvaline valylvaline: RN given refers to (L)-isomer. Val-Val : A dipeptide formed from two L-valine residues.	2.04	1	dipeptide	Mycoplasma genitalium metabolite
cysteinylglycine cysteinylglycine: RN given refers to (L)-isomer; RN for cpd without isomeric designation not in Chemlne 7/13/83. L-cysteinylglycine : A dipeptide consisting of glycine having an L-cysteinyl attached to its alpha-amino group. It is an intermediate metabolite in glutathione metabolism.	1.98	1	dipeptide zwitterion; dipeptide	Escherichia coli metabolite; human metabolite; Saccharomyces cerevisiae metabolite
trimethionine [no description available]	1.96	1	oligopeptide
sulfur Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.	2.13	1	chalcogen; nonmetal atom	macronutrient
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	1.98	1	cysteinium	fundamental metabolite
methionylglycine methionylglycine: RN given refers to (L)-isomer. Met-Gly : A dipeptide formed from L-methionine and glycine residues.	2.08	1	dipeptide	metabolite

Condition	Relationship Strength	Studies
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	7.9	3
Fish Diseases Diseases of freshwater, marine, hatchery or aquarium fish. This term includes diseases of both teleosts (true fish) and elasmobranchs (sharks, rays and skates).	2.17	1
Bacterial Infections, Gram-Negative [description not available]	2.17	1
Gram-Negative Bacterial Infections Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.	2.17	1
Deficiency Diseases A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed)	2.17	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.17	1
Complications, Pregnancy [description not available]	2.17	1
Pocket, Periodontal [description not available]	1.98	1
Periodontal Pocket An abnormal extension of a gingival sulcus accompanied by the apical migration of the epithelial attachment and bone resorption.	1.98	1

methionylmethionine

Description

Cross-References

Synonyms (27)

Research

Studies (11)

Market Indicators

Research Demand Index: 12.79

Study Types