Compounds > merulin a
Page last updated: 2024-11-13

merulin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

merulin A: cytotoxic compound from the culture broth extract of an endophytic fungus of Xylocarpus granatum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Xylocarpusgenus[no description available]MeliaceaeThe mahogany plant family of the order Sapindales, subclass Rosidae, class Magnoliopsida.[MeSH]

Cross-References

ID SourceID
PubMed CID46831716
CHEMBL ID1784537
MeSH IDM0547282

Synonyms (2)

Synonym
merulin a
CHEMBL1784537
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID601144Cytotoxicity against human MDA-MB-435 after 6 days by MTT method2011Journal of natural products, May-27, Volume: 74, Issue:5
Cytotoxic norsesquiterpene peroxides from the endophytic fungus Talaromyces flavus isolated from the mangrove plant Sonneratia apetala.
AID601147Cytotoxicity against human PC3 cells after 6 days by MTT method2011Journal of natural products, May-27, Volume: 74, Issue:5
Cytotoxic norsesquiterpene peroxides from the endophytic fungus Talaromyces flavus isolated from the mangrove plant Sonneratia apetala.
AID601153Antimicrobial activity against Aspergillus niger ATCC 13496 at 50 ug/ml2011Journal of natural products, May-27, Volume: 74, Issue:5
Cytotoxic norsesquiterpene peroxides from the endophytic fungus Talaromyces flavus isolated from the mangrove plant Sonneratia apetala.
AID601146Cytotoxicity against human HeLa cells after 6 days by MTT method2011Journal of natural products, May-27, Volume: 74, Issue:5
Cytotoxic norsesquiterpene peroxides from the endophytic fungus Talaromyces flavus isolated from the mangrove plant Sonneratia apetala.
AID601151Antimicrobial activity against Pseudomonas aeruginosa ATCC 25668 at 50 ug/ml2011Journal of natural products, May-27, Volume: 74, Issue:5
Cytotoxic norsesquiterpene peroxides from the endophytic fungus Talaromyces flavus isolated from the mangrove plant Sonneratia apetala.
AID601150Antimicrobial activity against Sarcina ventriculi ATCC 29068 at 50 ug/ml2011Journal of natural products, May-27, Volume: 74, Issue:5
Cytotoxic norsesquiterpene peroxides from the endophytic fungus Talaromyces flavus isolated from the mangrove plant Sonneratia apetala.
AID601149Antimicrobial activity against Escherichia coli ATCC 25922 at 50 ug/ml2011Journal of natural products, May-27, Volume: 74, Issue:5
Cytotoxic norsesquiterpene peroxides from the endophytic fungus Talaromyces flavus isolated from the mangrove plant Sonneratia apetala.
AID601152Antimicrobial activity against Candida albicans ATCC 10231 at 50 ug/ml2011Journal of natural products, May-27, Volume: 74, Issue:5
Cytotoxic norsesquiterpene peroxides from the endophytic fungus Talaromyces flavus isolated from the mangrove plant Sonneratia apetala.
AID601142Toxicity in Artemia salina2011Journal of natural products, May-27, Volume: 74, Issue:5
Cytotoxic norsesquiterpene peroxides from the endophytic fungus Talaromyces flavus isolated from the mangrove plant Sonneratia apetala.
AID601148Antimicrobial activity against Staphylococcus aureus ATCC 27154 at 50 ug/ml2011Journal of natural products, May-27, Volume: 74, Issue:5
Cytotoxic norsesquiterpene peroxides from the endophytic fungus Talaromyces flavus isolated from the mangrove plant Sonneratia apetala.
AID479127Cytotoxicity against human BT474 cells by MTT assay2010Journal of natural products, May-28, Volume: 73, Issue:5
Cytotoxic nor-chamigrane and chamigrane endoperoxides from a basidiomycetous fungus.
AID479128Cytotoxicity against human SW620 cells by MTT assay2010Journal of natural products, May-28, Volume: 73, Issue:5
Cytotoxic nor-chamigrane and chamigrane endoperoxides from a basidiomycetous fungus.
AID601145Cytotoxicity against human HepG2 after 6 days by MTT method2011Journal of natural products, May-27, Volume: 74, Issue:5
Cytotoxic norsesquiterpene peroxides from the endophytic fungus Talaromyces flavus isolated from the mangrove plant Sonneratia apetala.
AID601143Cytotoxicity against human MCF7 cells after 6 days by MTT method2011Journal of natural products, May-27, Volume: 74, Issue:5
Cytotoxic norsesquiterpene peroxides from the endophytic fungus Talaromyces flavus isolated from the mangrove plant Sonneratia apetala.
AID655891Antiangiogenic activity in Wistar rat aortic ring assessed as complete inhibition of microvessel sprouting at 25 uM after 7 days by phase-contrast microscopy2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Antiangiogenic effect of chamigrane endoperoxides from a Thai mangrove-derived fungus.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.28

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.28 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index5.08 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.28)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
epirubicin
Epirubicin: An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.		2.0610aminoglycoside;
anthracycline antibiotic;
anthracycline;
deoxy hexoside;
monosaccharide derivative;
p-quinones;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		antimicrobial agent;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
sesquiterpenes
[no description available]		2.1310
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		02.0510
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0510
African Sleeping Sickness
[description not available]		07.0710
Trypanosomiasis, African
A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.		02.0710