Compounds > meproscillarin
Page last updated: 2024-11-12

meproscillarin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

meproscillarin: semi-synthetic derivative of proscillaridin of Scilla (Liliaceae); structure in Negwer, 5th ed, #6625; RN given refers to (3beta)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
ScillagenusA plant genus of the family Asparagaceae. Members contain the cardiotonic PROSCILLARIDIN. The common name of squill is also used for DRIMIA.[MeSH]AsparagaceaeA family of flowering subshrubs and shrubs in the class Magnoliopsida.[MeSH]

Cross-References

ID SourceID
PubMed CID15942714
CHEMBL ID2106427
CHEBI ID135824
SCHEMBL ID36006
MeSH IDM0053474

Synonyms (38)

Synonym
meproscillarinum [inn-latin]
14-beta-bufa-4,20,22-trienolide, 3-beta-((6-deoxy-4-o-methyl-alpha-l-mannopyranosyl)oxy)-14-hydroxy-
ky 18
3beta-((6-deoxy-4-o-methyl-alpha-l-mannopyranosyl)oxy)-14-hydroxybufa-4,20,22-trienolide
meproscilarina [inn-spanish]
ky-18
meproscilarina [spanish]
meproscillarine [inn-french]
rambufaside
14-hydroxy-3-beta-((4-o-methyl-alpha-l-rhamnopyranosyl)oxy)-14-beta-bufa-4,20,22-trienlid
4-o-methyl-proscillaridin
proscillaridin-4-methyl ether
einecs 251-493-6
proscillaridin-4'-methyl ether
knoll 570
ranbufaside
meproscillarin
clift
CHEBI:135824
CHEMBL2106427
33396-37-1
meproscillarinum
wyr1723lo7 ,
meproscillarine
meproscillarin [inn:ban]
unii-wyr1723lo7
meproscilarina
3.beta.-((6-deoxy-4-o-methyl-.alpha.-l-mannopyranosyl)oxy)-14-hydroxybufa-4,20,22-trienolide
meproscillarin [inn]
meproscillarin [who-dd]
proscillaridin-4-methyl ether [mi]
meproscillarin [mart.]
SCHEMBL36006
5-((3s,8r,9s,10r,13r,14s,17r)-3-(((2r,3r,4s,5r,6s)-3,4-dihydroxy-5-methoxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)-14-hydroxy-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl)-2h-pyran-2-one
Q27293057
5-[(3s,8r,9s,10r,13r,14s,17r)-3-[(2r,3r,4s,5r,6s)-3,4-dihydroxy-5-methoxy-6-methyloxan-2-yl]oxy-14-hydroxy-10,13-dimethyl-1,2,3,6,7,8,9,11,12,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one
DTXSID101031613
AKOS040753000

Research Excerpts

Overview

Meproscillarin is a glycoside with a high bioavailability (about 70%) and an elimination independent of the renal function.

ExcerptReferenceRelevance
"Meproscillarin is a glycoside with a high bioavailability (about 70%) and an elimination independent of the renal function. "( [Meproscillarin in patients with renal failure and concomitant heart failure (author's transl)].
Beckmann, H; Belz, GG; Quellhorst, E, 1979)		2.61

Bioavailability

ExcerptReferenceRelevance
"Meproscillarin is a glycoside with a high bioavailability (about 70%) and an elimination independent of the renal function."( [Meproscillarin in patients with renal failure and concomitant heart failure (author's transl)].
Beckmann, H; Belz, GG; Quellhorst, E, 1979)		2.61

Dosage Studied

ExcerptRelevanceReference
"During a one week period patients with liver cirrhosis and a control group were treated with a repeated dosage of the new heart glcoside Meproscillarin."( [Plasma concentration and elimination behavior of the cardiac glycoside meproscillarin in patients with liver cirrhosis].
Beckmann, H; Burkert, K, 1983)		0.7
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
steroid lactone
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.37

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.37 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.37)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (40.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other2 (40.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
digitoxin
Digitoxin: A cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665). digitoxin : A cardenolide glycoside in which the 3beta-hydroxy group of digitoxigenin carries a 2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl trisaccharide chain.		3.0610cardenolide glycosideEC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor
digoxin
Digoxin: A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666). digoxin : A cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.		4.8521cardenolide glycoside;
steroid saponin		anti-arrhythmia drug;
cardiotonic drug;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
epitope
proscillaridin
Proscillaridin: A cardiotonic glycoside isolated from Scilla maritima var. alba (Squill).		5.3641organic molecular entity
ConditionIndicatedRelationship StrengthStudiesTrials
Cirrhosis, Liver
[description not available]		01.9610
Liver Cirrhosis
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.		06.9610
Cardiac Failure
[description not available]		01.9510
Chronic Kidney Failure
[description not available]		01.9510
Heart Failure
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.		06.9510
Kidney Failure, Chronic
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.		01.9510