menisporopsin A: antimalarial macrocyclic polylactone, from the fungus Menisporopsis theobromae; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 5276743 |
| CHEMBL ID | 450847 |
| MeSH ID | M0466490 |
| Synonym |
|---|
| menisporopsin a |
| 5h,9h,17h,21h,29h-tribenzo[h,r,z][1,5,11,15,21]pentaoxacyclooctacosin-5,9,17,21,29-pentone, 7,8,11,12,19,20,23,24,31,32,33,34-dodecahydro-2,4,14,16,26,28,33-heptahydroxy-7,11,19,23,31-pentamethyl-, (7r,11r,19r,23r,31r,33s)- |
| heptahydroxy(pentamethyl)[?]pentone |
| CHEMBL450847 |
| (4r,6s,16r,20r,30r,34r)-6,10,12,24,26,38,40-heptahydroxy-4,16,20,30,34-pentamethyl-3,15,19,29,33-pentaoxatetracyclo[34.4.0.08,13.022,27]tetraconta-1(36),8(13),9,11,22(27),23,25,37,39-nonaene-2,14,18,28,32-pentone |
Menisporopsin A is a fungal bioactive macrocyclic polylactone. It is produced by the fungus Menisporopsis theobromae BCC 4162.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Menisporopsin A is a fungal bioactive macrocyclic polylactone, the biosynthesis of which requires only reducing (R) and nonreducing (NR) polyketide synthases (PKSs) to guide a series of esterification and cyclolactonization reactions. " | ( SAXS reveals highly flexible interdomain linkers of tandem acyl carrier protein-thioesterase domains from a fungal nonreducing polyketide synthase. Bunnak, W; Crump, MP; Lazarus, CM; Race, PR; Wattana-Amorn, P; Winter, AJ, 2021) | 2.06 |
| "Menisporopsin A is a bioactive macrocyclic polylactone produced by the fungus Menisporopsis theobromae BCC 4162. " | ( Heterologous biosynthesis of a fungal macrocyclic polylactone requires only two iterative polyketide synthases. Bunnak, W; Lazarus, CM; Sriboonlert, A; Wattana-Amorn, P; Wonnapinij, P, 2019) | 1.96 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.64) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||