menisporopsin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

menisporopsin A: antimalarial macrocyclic polylactone, from the fungus Menisporopsis theobromae; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	5276743
CHEMBL ID	450847
MeSH ID	M0466490

Synonyms (5)

Synonym
menisporopsin a
5h,9h,17h,21h,29h-tribenzo[h,r,z][1,5,11,15,21]pentaoxacyclooctacosin-5,9,17,21,29-pentone, 7,8,11,12,19,20,23,24,31,32,33,34-dodecahydro-2,4,14,16,26,28,33-heptahydroxy-7,11,19,23,31-pentamethyl-, (7r,11r,19r,23r,31r,33s)-
heptahydroxy(pentamethyl)[?]pentone
CHEMBL450847
(4r,6s,16r,20r,30r,34r)-6,10,12,24,26,38,40-heptahydroxy-4,16,20,30,34-pentamethyl-3,15,19,29,33-pentaoxatetracyclo[34.4.0.08,13.022,27]tetraconta-1(36),8(13),9,11,22(27),23,25,37,39-nonaene-2,14,18,28,32-pentone

Research Excerpts

Overview

Menisporopsin A is a fungal bioactive macrocyclic polylactone. It is produced by the fungus Menisporopsis theobromae BCC 4162.

Excerpt	Reference	Relevance
"Menisporopsin A is a fungal bioactive macrocyclic polylactone, the biosynthesis of which requires only reducing (R) and nonreducing (NR) polyketide synthases (PKSs) to guide a series of esterification and cyclolactonization reactions. "	( SAXS reveals highly flexible interdomain linkers of tandem acyl carrier protein-thioesterase domains from a fungal nonreducing polyketide synthase. Bunnak, W; Crump, MP; Lazarus, CM; Race, PR; Wattana-Amorn, P; Winter, AJ, 2021)	2.06
"Menisporopsin A is a bioactive macrocyclic polylactone produced by the fungus Menisporopsis theobromae BCC 4162. "	( Heterologous biosynthesis of a fungal macrocyclic polylactone requires only two iterative polyketide synthases. Bunnak, W; Lazarus, CM; Sriboonlert, A; Wattana-Amorn, P; Wonnapinij, P, 2019)	1.96

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay ID	Title	Year	Journal	Article
AID401251	Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake	2004	Journal of natural products, Apr, Volume: 67, Issue:4	Isolation and structure elucidation of a novel antimalarial macrocyclic polylactone, menisporopsin A, from the fungus Menisporopsis theobromae.
AID401253	Cytotoxicity against human BC1 cells by colorimetric method	2004	Journal of natural products, Apr, Volume: 67, Issue:4	Isolation and structure elucidation of a novel antimalarial macrocyclic polylactone, menisporopsin A, from the fungus Menisporopsis theobromae.
AID401255	Antimicrobial activity against Candida albicans at 20ug/mL	2004	Journal of natural products, Apr, Volume: 67, Issue:4	Isolation and structure elucidation of a novel antimalarial macrocyclic polylactone, menisporopsin A, from the fungus Menisporopsis theobromae.
AID401252	Antimycobacterial activity against Mycobacterium tuberculosis H37Ra by microplate alamar blue assay	2004	Journal of natural products, Apr, Volume: 67, Issue:4	Isolation and structure elucidation of a novel antimalarial macrocyclic polylactone, menisporopsin A, from the fungus Menisporopsis theobromae.
AID401254	Cytotoxicity against human KB cells by colorimetric method	2004	Journal of natural products, Apr, Volume: 67, Issue:4	Isolation and structure elucidation of a novel antimalarial macrocyclic polylactone, menisporopsin A, from the fungus Menisporopsis theobromae.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (50.00)	29.6817
2010's	2 (33.33)	24.3611
2020's	1 (16.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.64

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.64 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.59 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.64)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

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