Page last updated: 2024-11-13

me-344

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

ME-344: a synthetic small molecule antineoplastic based on the isoflavan ring structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID68026984
SCHEMBL ID10073998
MeSH IDM000605810

Synonyms (14)

Synonym
me 344 [who-dd]
gtpl7961
(3r,4s)-3,4-bis(4-hydroxyphenyl)-8-methyl-3,4-dihydro-2h-chromen-7-ol
1374524-68-1
2h-1-benzopyran-7-ol, 3,4-dihydro-3,4-bis(4-hydroxyphenyl)-8-methyl-, (3r,4s)-
4,4'-(7-hydroxy-8-methylchroman-3,4-diyl)diphenol
me-344
unii-843g0tdv51
843g0tdv51 ,
SCHEMBL10073998
DB13062
4,4'-((3r,4s)-7-hydroxy-8-methylchroman-3,4-diyl)diphenol
Q27083823
DTXSID701031261

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
"The current phase 1, open-label, dose escalation study was conducted to establish the safety, tolerability, pharmacokinetic profile, and preliminary antitumor activity of the novel mitochondrial inhibitor ME-344 in patients with refractory solid tumors."( Phase 1, open-label, dose escalation, safety, and pharmacokinetics study of ME-344 as a single agent in patients with refractory solid tumors.
Bendell, JC; Burris, HA; Esquibel, V; Infante, JR; Jones, SF; Kurkjian, CD; Levin, W; Moore, KN; Moreno, O; Pant, S; Patel, MR, 2015
)
0.83
"8 µg/mL and the area under the concentration curve from time zero to infinity was 25."( Phase 1, open-label, dose escalation, safety, and pharmacokinetics study of ME-344 as a single agent in patients with refractory solid tumors.
Bendell, JC; Burris, HA; Esquibel, V; Infante, JR; Jones, SF; Kurkjian, CD; Levin, W; Moore, KN; Moreno, O; Pant, S; Patel, MR, 2015
)
0.65
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (71.43)24.3611
2020's2 (28.57)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.88

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index26.88 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index29.35 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (26.88)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (28.57%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (71.43%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]