ME-344: a synthetic small molecule antineoplastic based on the isoflavan ring structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
---|---|
PubMed CID | 68026984 |
SCHEMBL ID | 10073998 |
MeSH ID | M000605810 |
Synonym |
---|
me 344 [who-dd] |
gtpl7961 |
(3r,4s)-3,4-bis(4-hydroxyphenyl)-8-methyl-3,4-dihydro-2h-chromen-7-ol |
1374524-68-1 |
2h-1-benzopyran-7-ol, 3,4-dihydro-3,4-bis(4-hydroxyphenyl)-8-methyl-, (3r,4s)- |
4,4'-(7-hydroxy-8-methylchroman-3,4-diyl)diphenol |
me-344 |
unii-843g0tdv51 |
843g0tdv51 , |
SCHEMBL10073998 |
DB13062 |
4,4'-((3r,4s)-7-hydroxy-8-methylchroman-3,4-diyl)diphenol |
Q27083823 |
DTXSID701031261 |
Excerpt | Reference | Relevance |
---|---|---|
"The current phase 1, open-label, dose escalation study was conducted to establish the safety, tolerability, pharmacokinetic profile, and preliminary antitumor activity of the novel mitochondrial inhibitor ME-344 in patients with refractory solid tumors." | ( Phase 1, open-label, dose escalation, safety, and pharmacokinetics study of ME-344 as a single agent in patients with refractory solid tumors. Bendell, JC; Burris, HA; Esquibel, V; Infante, JR; Jones, SF; Kurkjian, CD; Levin, W; Moore, KN; Moreno, O; Pant, S; Patel, MR, 2015) | 0.83 |
"8 µg/mL and the area under the concentration curve from time zero to infinity was 25." | ( Phase 1, open-label, dose escalation, safety, and pharmacokinetics study of ME-344 as a single agent in patients with refractory solid tumors. Bendell, JC; Burris, HA; Esquibel, V; Infante, JR; Jones, SF; Kurkjian, CD; Levin, W; Moore, KN; Moreno, O; Pant, S; Patel, MR, 2015) | 0.65 |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 5 (71.43) | 24.3611 |
2020's | 2 (28.57) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (26.88) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 2 (28.57%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (71.43%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |