MDL 29311: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 131127 |
| CHEMBL ID | 102729 |
| SCHEMBL ID | 5692187 |
| MeSH ID | M0193112 |
| Synonym |
|---|
| 129895-82-5 |
| 4,4'-(methylenebis(thio))bis(2,6-bis(1,1-dimethylethyl))phenol |
| mdl 29,311 |
| phenol, 4,4'-(methylenebis(thio))bis(2,6-bis(1,1-dimethylethyl)- |
| mdl-29311 |
| mdl 29311 |
| CHEMBL102729 |
| 2,6-ditert-butyl-4-[(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylmethylsulfanyl]phenol |
| SCHEMBL5692187 |
| methyl-bis-(4-hydroxy-3,5-di-t-butyl-phenylsulfide) |
| DTXSID90156262 |
| 4,4'-methylenebis(sulfanediyl)bis(2,6-di-tert-butylphenol) |
| mdl 29311;mdl29311;4,4'-(methylenebisthio)bis(2,6-di-tert-butylphenol) |
| BCP32982 |
| AMY38745 |
| 4,4'-(methylenebis(sulfanediyl))bis(2,6-di-tert-butylphenol) |
MDL 29311 is an antioxidant that lowers plasma triglycerides and raises high density lipoprotein (HDL) cholesterol in rats. MDL 29 311 is an analog of probucol that shares probucOL's antioxidant and antiatherogenic properties.
| Excerpt | Reference | Relevance |
|---|---|---|
| "MDL 29311 is an analog of probucol that shares probucol's antioxidant and antiatherogenic properties. " | ( MDL 29311, an analog of probucol, decreases triglycerides in rats by increasing hepatic clearance of very-low-density lipoprotein. Barnhart, RL; Jackson, RL; Robinson, KM; Sheetz, MJ, 1994) | 3.17 |
| "MDL 29311 is an antioxidant that lowers plasma triglycerides and raises high density lipoprotein (HDL) cholesterol in rats. " | ( MDL 29311, a phenolic antioxidant, interferes with the interaction of apoC with VLDL: a possible explanation for its triglyceride-lowering effect. Sheetz, MJ, 1995) | 3.18 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "MDL 29311 treatment did not affect the rate of triglyceride entry into the plasma." | ( MDL 29311, an analog of probucol, decreases triglycerides in rats by increasing hepatic clearance of very-low-density lipoprotein. Barnhart, RL; Jackson, RL; Robinson, KM; Sheetz, MJ, 1994) | 2.45 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID166672 | Prevention of Cu2+-induced lipid peroxidation of LDL. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | Antioxidant activity of probucol and its analogues in hypercholesterolemic Watanabe rabbits. |
| AID166977 | % atherosclerotic lesions in WHHL rabbits. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | Antioxidant activity of probucol and its analogues in hypercholesterolemic Watanabe rabbits. |
| AID166669 | Compound was evaluated for the ability to lower total serum cholesterol levels in 5 Watanabe heritable hyperlipidemic (WHHL) rabbits on day 84. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | Antioxidant activity of probucol and its analogues in hypercholesterolemic Watanabe rabbits. |
| AID166666 | Compound was evaluated for the ability to lower total serum cholesterol levels in 5 Watanabe heritable hyperlipidemic (WHHL) rabbits on day 0. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | Antioxidant activity of probucol and its analogues in hypercholesterolemic Watanabe rabbits. |
| AID166668 | Compound was evaluated for the ability to lower total serum cholesterol levels in 5 Watanabe heritable hyperlipidemic (WHHL) rabbits on day 56. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | Antioxidant activity of probucol and its analogues in hypercholesterolemic Watanabe rabbits. |
| AID230859 | Molar content of compound in low-density lipoprotein (LDL) was obtained from the ratio of molecules to that of LDL particles. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | Antioxidant activity of probucol and its analogues in hypercholesterolemic Watanabe rabbits. |
| AID166667 | Compound was evaluated for the ability to lower total serum cholesterol levels in 5 Watanabe heritable hyperlipidemic (WHHL) rabbits on day 28. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | Antioxidant activity of probucol and its analogues in hypercholesterolemic Watanabe rabbits. |
| AID166670 | Compound concentration in low-density lipoprotein (LDL). | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | Antioxidant activity of probucol and its analogues in hypercholesterolemic Watanabe rabbits. |
| AID167029 | Compound concentration in serum. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | Antioxidant activity of probucol and its analogues in hypercholesterolemic Watanabe rabbits. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (87.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.87) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||