maoecrystal V: cytotoxic; from the leaves of a Chinese medicinal herb, Isodon eriocalyx; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Isodon | genus | A plant genus of the family LAMIACEAE used in TRADITIONAL CHINESE MEDICINE.[MeSH] | Lamiaceae | The mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 21575535 |
| MeSH ID | M0541744 |
| Synonym |
|---|
| maoecrystal v |
| (-)-maoecrystal v |
| unii-f7oon8600z |
| maoecrystal v [mi] |
| 9h-3,9b-ethano-4a,9a-(methanoxymethano)dibenzofuran-1,9,14(2h)-trione, 3,4,5a,6-tetrahydro-2,6,6-trimethyl-, (2r,3r,4ar,5ar,9ar,9br)- |
| 807630-42-8 |
| (2r,3r,4ar,5ar,9ar,9br)-2,6,6-trimethyl-3,4-dihydro-5ah-3,9b-ethano-4a,9a-(methanooxymethano)dibenzo(b,d)furan-1,9,14(2h,6h)-trione |
| F7OON8600Z , |
| (1r,3r,8r,9r,11r,12r)-4,4,11-trimethyl-2,15-dioxapentacyclo[6.5.3.29,12.01,9.03,8]octadec-5-ene-7,10,14-trione |
Maoecrystal V (1) was originally isolated from the leaves of the Chinese medicinal herb Isodon eriocalyx in 2004. It has been found to be selectively cytotoxic towards HeLa cells, with an IC50 value of 20 ng mL(-1)
| Excerpt | Reference | Relevance |
|---|---|---|
| "Maoecrystal V (1) is a novel diterpenoid, which was originally isolated from the leaves of the Chinese medicinal herb Isodon eriocalyx in 2004 by Sun et al.1 It has been found to be selectively cytotoxic towards HeLa cells, with an IC50 value of 20 ng mL(-1) . " | ( Total synthesis of maoecrystal V. Gong, JX; Lin, G; Shao, WB; Yang, Z; Zhang, WB, 2015) | 2.19 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 14 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (25.46) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (7.14%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 13 (92.86%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||