maoecrystal A: from the leaves of Isodon eriocalyx var. laxiflora (Labiatae); structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Isodon | genus | A plant genus of the family LAMIACEAE used in TRADITIONAL CHINESE MEDICINE.[MeSH] | Lamiaceae | The mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH] |
| Isodon eriocalyx | species | [no description available] | Lamiaceae | The mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 20056131 |
| CHEMBL ID | 465509 |
| MeSH ID | M0448736 |
| Synonym |
|---|
| maoecrystal a |
| CHEMBL465509 |
| 96850-30-5 |
| AC-34506 |
| FT-0701687 |
| AKOS037514733 |
| HY-N2017 |
| maoecrystala |
| mfcd02259438 |
| [(1s,2s,5r,7r,8s,10s,11r,13r)-10-hydroxy-12,12-dimethyl-6-methylidene-9,16-dioxo-14-oxapentacyclo[11.2.2.15,8.01,11.02,8]octadecan-7-yl] acetate |
| CS-0018337 |
| MS-26446 |
Maoecrystal A is an ent-kaurane-type diterpene isolated from Rabdosia eriocalyx (Dunn) Hara.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Maoecrystal A (MC-A) is an ent-kaurane-type diterpene isolated from Rabdosia eriocalyx (Dunn) Hara. " | ( Developing an UPLC-MS/MS method to quantify maoecrystal A in rat plasma: Application to a pharmacokinetic study. Boughaba, F; Gao, S; He, Y; Ma, W; Qin, C; Yang, G; Zhang, C; Zhang, Y, 2018) | 2.18 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " The purpose of this study is to develop an UPLC-MS/MS method to quantify MC-A in plasma and determine its pharmacokinetic properties using an animal model." | ( Developing an UPLC-MS/MS method to quantify maoecrystal A in rat plasma: Application to a pharmacokinetic study. Boughaba, F; Gao, S; He, Y; Ma, W; Qin, C; Yang, G; Zhang, C; Zhang, Y, 2018) | 0.74 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID357242 | Cytotoxicity against human T24 cells after 48 hrs by MTT assay | 2002 | Journal of natural products, Dec, Volume: 65, Issue:12 | Cytotoxic 3,20-epoxy-ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora. |
| AID357241 | Cytotoxicity against human A549 cells after 48 hrs by MTT assay | 2002 | Journal of natural products, Dec, Volume: 65, Issue:12 | Cytotoxic 3,20-epoxy-ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora. |
| AID357240 | Cytotoxicity against human K562 cells after 48 hrs by MTT assay | 2002 | Journal of natural products, Dec, Volume: 65, Issue:12 | Cytotoxic 3,20-epoxy-ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.53) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||