mannonate profile

mannonate: labeled with Tc 99m; used in renal scanning [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

mannonic acid : A hexonic acid involved in the glucuronate metabolism. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

D-mannonic acid : The D-stereoisomer of mannonic acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	3246006
CHEBI ID	33076
SCHEMBL ID	537704
MeSH ID	M0062315

Synonyms (26)

Synonym
CHEBI:33076
d-mannonic acid
nsc-1945
NCGC00013015
mannonate
D-MANNONATE ,
642-99-9
C00514
NCI1945
NCISTRUC2_000142
NCISTRUC1_000222
NCGC00096142-01
(2s,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoic acid
CCG-37685
NCGC00013015-03
NCGC00013015-02
mannonic acid
SCHEMBL537704
DTXSID40331426
(2s,3s,4r,5r)-2,3,4,5,6-pentakis(oxidanyl)hexanoic acid
DTXSID20873879
Q27104257
mannonic acid nist
rel-(2s,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoic acid
d-mannonicacid
AKOS040748265

Drug Classes (1)

Class	Description
mannonic acid	A hexonic acid involved in the glucuronate metabolism.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (8)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	0.6310	0.0032	45.4673	12,589.2998	AID2517
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	6.4776	0.0040	23.8416	100.0000	AID485290; AID489007
Chain A, Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	Potency	14.0919	0.1409	11.1940	39.8107	AID2451
TDP1 protein	Homo sapiens (human)	Potency	20.0850	0.0008	11.3822	44.6684	AID686978; AID686979
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Homo sapiens (human)	Potency	0.1995	0.0013	7.7625	44.6684	AID914; AID915
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	89.1251	0.0501	27.0736	89.1251	AID588590
geminin	Homo sapiens (human)	Potency	13.3359	0.0046	11.3741	33.4983	AID624297
lamin isoform A-delta10	Homo sapiens (human)	Potency	35.4813	0.8913	12.0676	28.1838	AID1487
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay ID	Title	Year	Journal	Article
AID504749	qHTS profiling for inhibitors of Plasmodium falciparum proliferation	2011	Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043	Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (20.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	3 (60.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.44

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	23.44 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.80 (4.65)
Search Engine Demand Index	21.17 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (23.44)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
gluconic acid gluconic acid: zinc gluconate has anti-inflammatory activity; RN given refers to (D)-isomer; all RRs refers to (D)-isomer unless otherwise noted. ketogluconic acid : A gluconic acid that contains a ketonic carbonyl group.. D-gluconic acid : A gluconic acid having D-configuration.	2.1	1	gluconic acid	chelator; Penicillium metabolite
copper gluconate Gluconates: Derivatives of gluconic acid (the structural formula HOCH2(CHOH)4COOH), including its salts and esters.	2.49	2	organic molecular entity
mannose mannopyranose : The pyranose form of mannose.	1.95	1	D-aldohexose; D-mannose; mannopyranose	metabolite
2-oxo-3-deoxygalactonic acid 2-dehydro-3-deoxy-D-galactonic acid : The 2-dehydro-3-deoxy derivative of D-galactonic acid.	2.07	1	hexonic acid; ketoaldonic acid	Escherichia coli metabolite
nad NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.	6.95	1	organophosphate oxoanion	cofactor; human metabolite; hydrogen acceptor; Saccharomyces cerevisiae metabolite

mannonate

Description