Compounds > magnocurarine
Page last updated: 2024-12-06

magnocurarine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Magnocurarine is a naturally occurring bisbenzylisoquinoline alkaloid isolated from the bark of the South American plant _Magnolia grandiflora_. It is a potent neuromuscular blocking agent that acts by blocking the transmission of nerve impulses to muscles, leading to paralysis. The compound has been studied for its potential therapeutic use in medicine, particularly as a muscle relaxant during surgery. It is also of interest to researchers studying the structure and function of the neuromuscular junction.'

magnocurarine: RN given refers to (R)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID53266
CHEMBL ID1187634
CHEBI ID80846
MeSH IDM0139530

Synonyms (14)

Synonym
SDCCGMLS-0066966.P001 ,
magnocurarine
C16991
6801-40-7
(1r)-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2,2-dimethyl-3,4-dihydro-1h-isoquinolin-2-ium-7-ol
CHEMBL1187634
isoquinolinium, 1,2,3,4-tetrahydro-7-hydroxy-1-((4-hydroxyphenyl)methyl)-6-methoxy-2,2-dimethyl-, (r)-
AKOS015897149
CHEBI:80846 ,
DTXSID10218199
Q27151342
CS-0034355
D85081
HY-N6609
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
isoquinolinesA class of organic heteropolycyclic compound consisting of isoquinoline and its substitution derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (50.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's2 (25.00)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.18

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.18 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.73 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.18)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
methanol
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.		2.2110alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
1-phenylpropanol
1-phenylpropanol: structure in first source		2.2110organic molecular entity
isoquinoline
[no description available]		2.2110azaarene;
isoquinolines;
mancude organic heterobicyclic parent;
ortho-fused heteroarene
boldine
[no description available]		2.0210aporphine alkaloid
laurotetanine
laurotetanine: isolated from Tetranthera & Lindera benzoin L. from family Lauraceae; structure		2.0210isoquinoline alkaloid
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		2.2110D-glucopyranoseepitope;
mouse metabolite
magnolol
[no description available]		2.6930biphenyls
honokiol
[no description available]		2.4220biphenyls
magnoflorine
magnoflorine: opium alkaloid having the aporphine configuration; RN given refers to parent cpd(S)-isomer; structure. (S)-magnoflorine : An aporphine alkaloid that is (S)-corytuberine in which the nitrogen has been quaternised by an additional methyl group.		2.6120aporphine alkaloid;
quaternary ammonium ion		plant metabolite
cycleanine
cycleanine: a bisbenzyl-bisisoquinoline alkaloid isolated from Chinese herb Stephania epigeae Lu; used for controlling blood pressure during anesthesia; RN refers to the R,R-isomer (cycleanine); isocycleanine is the R,S-isomer;		2.2110bisbenzylisoquinoline alkaloid;
isoquinolines
isoteolin
isoteolin: mixture of isomers isoboldine (RN 3019-51-0) & bracteoline (RN 25651-04-1)		2.0210aporphine alkaloid
chondocurine (1beta)-(+-)-isomer
curine: structure in first source		2.2110aromatic ether
guatteguamerine
guatteguamerine: a neuroprotective agent with antioxidant properties; isolated from bark of Guatteria gaumer; structure given in first source; RN given refers to (R-(R*,R*))-isomer		2.3110bisbenzylisoquinoline alkaloid;
isoquinolines
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		2.6930
glycosides
[no description available]		2.2110
armepavine
armepavine: reticuline-like; RN given refers to cpd without isomeric designation		2.3110
acteoside
acteoside: a protein kinase C inhibitor with hepatoprotective, anti-asthmatic, and analgesic activities; a phenylethanoid glycoside related to isoacteoside; from leaves of Lippia multiflora (Verbenaceae). acteoside : A glycoside that is the alpha-L-rhamnosyl-(1->3)-beta-D-glucoside of hydroxytyrosol in which the hydroxy group at position 4 of the glucopyranosyl moiety has undergone esterification by formal condensation with trans-caffeic acid.		2.2110catechols;
cinnamate ester;
disaccharide derivative;
glycoside;
polyphenol		anti-inflammatory agent;
antibacterial agent;
antileishmanial agent;
neuroprotective agent;
plant metabolite
cardiovascular agents
Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.		1.9310
ConditionIndicatedRelationship StrengthStudiesTrials