Compounds > ly 195448
Page last updated: 2024-12-07

ly 195448

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4-(3-(2-hydroxy-2-phenyl)ethylamino-3-methylbutyl)benzamide: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID130695
SCHEMBL ID10770012
MeSH IDM0167961

Synonyms (18)

Synonym
ly-195448
4-[3-[[(2r)-2-hydroxy-2-phenylethyl]amino]-3-methylbutyl]benzamide
unii-j2i8s597g4
4-(3-(2-hydroxy-2-phenyl)ethylamino-3-methylbutyl)benzamide
ly-199123
j2i8s597g4 ,
ly 119123
benzamide, 4-(3-((2-hydroxy-2-phenylethyl)amino)-3-methylbutyl)-, (r)-
111974-80-2
SCHEMBL10770012
ly195448 free base
ly-195448 free base
benzamide, 4-(3-(((2r)-2-hydroxy-2-phenylethyl)amino)-3-methylbutyl)-
DTXSID50149796
benzamide, 4-[3-[(2-hydroxy-2-phenylethyl)amino]-3-methylbutyl]-, (r)- (9ci)
Q27281068
PD162125
AKOS040749962

Research Excerpts

Overview

LY 195448 is a phenethanolamine that has shown anti-tumour activity in a range of murine tumour models. Its mechanism of action is unknown.

ExcerptReferenceRelevance
"LY 195448 is a phenethanolamine that has shown anti-tumour activity in a range of murine tumour models, although its mechanism of action is unknown. "( Phase I clinical and pharmacokinetic study of LY 195448.
Adams, L; Bayssas, M; Boder, GG; Cassidy, J; Kaye, SB; Lewis, C; Rankin, EM; Setanoians, A, 1989)		1.98

Pharmacokinetics

ExcerptReferenceRelevance
" Murine pharmacokinetics were assessed at a dose level that was effective in experimental tumours and compared with human pharmacokinetic parameters derived from this study."( Phase I clinical and pharmacokinetic study of LY 195448.
Adams, L; Bayssas, M; Boder, GG; Cassidy, J; Kaye, SB; Lewis, C; Rankin, EM; Setanoians, A, 1989)		0.54
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (40.00)18.7374
1990's3 (60.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.74

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.74 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.54 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.74)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		01.9710
Cancer of Colon
[description not available]		01.9710
Blood Pressure, Low
[description not available]		01.9710
Benign Neoplasms
[description not available]		01.9710
Cancer of Rectum
[description not available]		01.9710
Tachyarrhythmia
[description not available]		01.9710
Action Tremor
[description not available]		01.9710
Breast Neoplasms
Tumors or cancer of the human BREAST.		01.9710
Colonic Neoplasms
Tumors or cancer of the COLON.		01.9710
Hypotension
Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.		01.9710
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		01.9710
Rectal Neoplasms
Tumors or cancer of the RECTUM.		01.9710
Tachycardia
Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.		01.9710
Tremor
Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.		01.9710