Compounds > lhrh, acetyl-2-(2-naphthyl)-ala(1)-4-f-phe(2)-trp(3)-arg(6)-
Page last updated: 2024-11-12

lhrh, acetyl-2-(2-naphthyl)-ala(1)-4-f-phe(2)-trp(3)-arg(6)-

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

LHRH, acetyl-2-(2-naphthyl)-Ala(1)-4-F-Phe(2)-Trp(3)-Arg(6)-: gonadorelin antagonist; RN given refers to all D-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID16131124
MeSH IDM0124360

Synonyms (15)

Synonym
lhrh, acetyl-2-(2-naphthyl)-ala(1)-4-f-phe(2)-trp(3)-arg(6)-
(ac-d-nal(2)(sup 1)-4-f-d-phe(sup 2)-d-trp(sup 3)-d-arg(sup 6))-gnrh
(ac-d-nal(2)(sup 1)-4-f-d-phe(sup 2)-d-trp(sup 3)-d-arg(sup 6))-lhrh
1-acetylnaphthylalanyl-2-para-fluorophenylalanyl-3-tryptophyl-6-arginine-lhrh
orf 18260
ac-d-nal(2)(1)-4f-phe(2)-trp(3)-arg(6)-lhrh
ac-(2)-d-nal(1)-4f-phe(2)-trp(3)-arg(6)-gnrh
lhrh, 1-acetylnaphthylalanyl-2-4-fluorophenylalanyl-3-tryptophyl-6-arginine-
86855-16-5
orf-18260
wy 45760
acetyl-beta-naphthyl-ala(1)-4f-phe(2)-trp(3)-arg(6)-lhrh
unii-c1py6r3nm9
c1py6r3nm9 ,
DTXSID00235875
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (66.67)18.7374
1990's5 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.58

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.58 (24.57)
Research Supply Index2.77 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.58)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
egtazic acid
Egtazic Acid: A chelating agent relatively more specific for calcium and less toxic than EDETIC ACID.. ethylene glycol bis(2-aminoethyl)tetraacetic acid : A diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively.		1.9710diether;
tertiary amino compound;
tetracarboxylic acid		chelator
n-methylaspartate
N-Methylaspartate: An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NMDA).. N-methyl-D-aspartic acid : An aspartic acid derivative having an N-methyl substituent and D-configuration.		2.3820amino dicarboxylic acid;
D-alpha-amino acid;
D-aspartic acid derivative;
secondary amino compound		neurotransmitter agent
azides
Azides: Organic or inorganic compounds that contain the -N3 group.. azide : Any nitrogen molecular entity containing the group -N3.		1.9710pseudohalide anionmitochondrial respiratory-chain inhibitor
buserelin
Buserelin: A potent synthetic analog of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications.		1.9610oligopeptide
dizocilpine maleate
Dizocilpine Maleate: A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.. dizocilpine maleate : A maleate salt obtained by reaction of dizocilpine with one equivalent of maleic acid.		1.9810maleate salt;
tetracyclic antidepressant		anaesthetic;
anticonvulsant;
neuroprotective agent;
nicotinic antagonist;
NMDA receptor antagonist
calcimycin
Calcimycin: An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.		1.9710benzoxazole
detirelix
detirelix: LHRH antagonist		1.9710
iturelix
iturelix: a gonadotropin-releasing hormone antagonist		1.9710
ganirelix
[no description available]		1.9710polypeptide
histrelin
histrelin: gonadotropin releasing hormone agonist. histrelin : An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, 1-benzyl-D-histidyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the diacetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.		1.9610oligopeptideantineoplastic agent;
gonadotropin releasing hormone agonist
lhrh, n-epsilon-azidobenzoyl-lys(6)-
[no description available]		1.9710
ConditionIndicatedRelationship StrengthStudiesTrials
Anasarca
[description not available]		01.9610
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		01.9610
Endometrioma
An enlarged area of ENDOMETRIOSIS that resembles a tumor. It is usually found in the OVARY. When it is filled with old blood, it is known as a chocolate cyst.		01.9710
Endometriosis
A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.		01.9710
Anaphylactic Reaction
[description not available]		01.9610
Anaphylaxis
An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.		01.9610
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		01.9610