Compounds > leuhistin
Page last updated: 2024-12-07

leuhistin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

leuhistin: aminopeptidases N inhibitor from Bacillus laterosporus BMI156-14F1; structure given in second source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID131057
SCHEMBL ID12609365
MeSH IDM0190645

Synonyms (12)

Synonym
129085-76-3
3-amino-2-hydroxy-2-(1h-imidazol-4-ylmethyl)-5-methylhexanoic acid
1h-imidazole-4-propanoic acid, alpha-(1-amino-3-methylbutyl)-alpha-hydroxy-, (r-(r*,s*))-
leuhistine
leuhistin
(2r,3s)-3-amino-2-hydroxy-2-(1h-imidazol-5-ylmethyl)-5-methylhexanoic acid
SCHEMBL12609365
DTXSID20926293
3-amino-2-hydroxy-2-[(1h-imidazol-5-yl)methyl]-5-methylhexanoic acid
(2r,3s)-2-((1h-imidazol-4-yl)methyl)-3-amino-2-hydroxy-5-methylhexanoic acid
(2r,3s)-3-amino-2-hydroxy-2-(1h-imidazol-4-ylmethyl)-5-methylhexanoic acid
AKOS040747055

Research Excerpts

Effects

ExcerptReferenceRelevance
"Leuhistin has been isolated from the culture broth of Bacillus laterosporus BMI156-14F1 as part of a program designed to find microorganism-produced inhibitors of aminopeptidase M (AP-M). "( Leuhistin, a new inhibitor of aminopeptidase M, produced by Bacillus laterosporus BMI156-14F1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities.
Aoyagi, T; Hamada, M; Ikeda, T; Matsuda, N; Takeuchi, T; Yoshida, S, 1991)		3.17
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (40.00)18.2507
2000's4 (40.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.49

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index19.49 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.25 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (19.49)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
phosphoserine
Phosphoserine: The phosphoric acid ester of serine.		210non-proteinogenic alpha-amino acid;
O-phosphoamino acid;
serine derivative		human metabolite
thiorphan
Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.		2.4520N-acyl-amino acid
leucine
Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.		2.3820amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
histidine
Histidine: An essential amino acid that is required for the production of HISTAMINE.. L-histidine : The L-enantiomer of the amino acid histidine.. histidine : An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.		1.9710amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
pyrrolidonecarboxylic acid
Pyrrolidonecarboxylic Acid: A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.. 5-oxo-L-proline : An optically active form of 5-oxoproline having L-configuration.		2.01105-oxoproline;
L-proline derivative;
non-proteinogenic L-alpha-amino acid		algal metabolite
substance p
[no description available]		2.0110peptideneurokinin-1 receptor agonist;
neurotransmitter;
vasodilator agent
ubenimex
ubenimex: growth inhibitor		1.9810
amastatin
amastatin: structure; inhibits aminopeptidase. amastatin : A tetrapeptide comprising (2S,3R)-3-amino-2-hydroxy-5-methylhexanoyl, L-valyl, L-valyl and L-aspartic acid units joined in sequence		2.6930tetrapeptideEC 3.4.11.* (aminopeptidase) inhibitor;
protease inhibitor
actinonin
actinonin: natural hydroxamic acid, pseudopeptide antibiotic isolated from Streptomyces species; structure		2.420
arphamenine a
arphamenine A: from Chromobacterium violaceum; structure given in second source		1.9810
probestin
probestin: inhibitor of aminopeptidase M; from Streptomyces azureus MH663-2F6; structure given in first source		2.3820
ConditionIndicatedRelationship StrengthStudiesTrials