Compounds > leucyl-prolyl-proline
Page last updated: 2024-12-10

leucyl-prolyl-proline

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID3078466
CHEBI ID159471
SCHEMBL ID6679097
MeSH IDM0529610

Synonyms (12)

Synonym
l-proline, 1-(1-l-leucyl-l-prolyl)-
1-(1-l-leucyl-l-prolyl)-l-proline
(2s)-1-[(2s)-1-[(2s)-2-amino-4-methylpentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
CHEBI:159471
leu-pro-pro
121305-26-8
h-leu-pro-pro-oh
SCHEMBL6679097
DTXSID40153221
mfcd01698774
leucyl-prolyl-proline
l-leucyl-l-prolyl-l-proline

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" The aim of this study was to characterize the pharmacokinetic behavior of IPP, LPP, and VPP in a conscious pig model."( Pharmacokinetics of proline-rich tripeptides in the pig.
Deutz, NE; Duchateau, GS; Kies, AK; Ten Have, GA; van der Pijl, PC, 2008)		0.35

Bioavailability

ExcerptReferenceRelevance
" CasH prolonged portal bioavailability with 18 min (absorption half-life, synthetic XPP: 15 ± 2 min, CasH: 33 ± 3 min, p<0."( Enhanced Lacto-Tri-Peptide Bio-Availability by Co-Ingestion of Macronutrients.
Deutz, NE; Kies, AK; Ten Have, GA; van der Pijl, PC, 2015)		0.42
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
oligopeptideA peptide containing a relatively small number of amino acids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (42.86)29.6817
2010's3 (42.86)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.47 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.55 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
captopril
Captopril: A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.. captopril : A L-proline derivative in which L-proline is substituted on nitrogen with a (2S)-2-methyl-3-sulfanylpropanoyl group. It is used as an anti-hypertensive ACE inhibitor drug.		2.4920alkanethiol;
L-proline derivative;
N-acylpyrrolidine;
pyrrolidinemonocarboxylic acid		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
bradykinin
[no description available]		2.1510oligopeptidehuman blood serum metabolite;
vasodilator agent
cathepsin g
Cathepsin G: A serine protease found in the azurophil granules of NEUTROPHILS. It has an enzyme specificity similar to that of chymotrypsin C.		2.0510
valyl-prolyl-proline
Val-Pro-Pro : A tripeptide composed of L-valine and two L-proline units joined by peptide linkages.		3.3260tripeptidemetabolite
isoleucyl-prolyl-proline
[no description available]		3.3260oligopeptide
phytosterols
Phytosterols: A class of organic compounds known as sterols or STEROIDS derived from plants.. phytosterols : Sterols similar to cholesterol which occur in plants and vary only in carbon side chains and/or presence or absence of a double bond.		2.0510
caseins
Caseins: A mixture of related phosphoproteins occurring in milk and cheese. The group is characterized as one of the most nutritive milk proteins, containing all of the common amino acids and rich in the essential ones.		2.4620
ConditionIndicatedRelationship StrengthStudiesTrials
Blood Pressure, High
[description not available]		02.4920
Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.		02.4920