Page last updated: 2024-12-08

latifolin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

latifolin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID340211
CHEMBL ID2397757
SCHEMBL ID9418029
MeSH IDM0539346

Synonyms (15)

Synonym
nsc-370336
(-)-(r)-latifolin
latifolin (+) - (r)
nsc370336
SCHEMBL9418029
(r)-5,2'-dihydroxy-2,4-dimethoxydalbergiquinol
latifolin
LMPK12100064
bdbm50018963
5-[(1r)-1-(2-hydroxyphenyl)prop-2-enyl]-2,4-dimethoxyphenol
CHEMBL2397757
10154-42-4
F92738
(r)-5-(1-(2-hydroxyphenyl)allyl)-2,4-dimethoxyphenol
AKOS040761974
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Beta-secretase 1Homo sapiens (human)IC50 (µMol)180.00000.00061.619410.0000AID1153325
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (16)

Processvia Protein(s)Taxonomy
proteolysisBeta-secretase 1Homo sapiens (human)
membrane protein ectodomain proteolysisBeta-secretase 1Homo sapiens (human)
response to lead ionBeta-secretase 1Homo sapiens (human)
protein processingBeta-secretase 1Homo sapiens (human)
amyloid-beta formationBeta-secretase 1Homo sapiens (human)
amyloid precursor protein catabolic processBeta-secretase 1Homo sapiens (human)
positive regulation of neuron apoptotic processBeta-secretase 1Homo sapiens (human)
amyloid-beta metabolic processBeta-secretase 1Homo sapiens (human)
detection of mechanical stimulus involved in sensory perception of painBeta-secretase 1Homo sapiens (human)
prepulse inhibitionBeta-secretase 1Homo sapiens (human)
cellular response to copper ionBeta-secretase 1Homo sapiens (human)
cellular response to manganese ionBeta-secretase 1Homo sapiens (human)
presynaptic modulation of chemical synaptic transmissionBeta-secretase 1Homo sapiens (human)
signaling receptor ligand precursor processingBeta-secretase 1Homo sapiens (human)
cellular response to amyloid-betaBeta-secretase 1Homo sapiens (human)
amyloid fibril formationBeta-secretase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (8)

Processvia Protein(s)Taxonomy
amyloid-beta bindingBeta-secretase 1Homo sapiens (human)
endopeptidase activityBeta-secretase 1Homo sapiens (human)
aspartic-type endopeptidase activityBeta-secretase 1Homo sapiens (human)
protein bindingBeta-secretase 1Homo sapiens (human)
peptidase activityBeta-secretase 1Homo sapiens (human)
beta-aspartyl-peptidase activityBeta-secretase 1Homo sapiens (human)
enzyme bindingBeta-secretase 1Homo sapiens (human)
protein serine/threonine kinase bindingBeta-secretase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (20)

Processvia Protein(s)Taxonomy
lysosomeBeta-secretase 1Homo sapiens (human)
endosomeBeta-secretase 1Homo sapiens (human)
early endosomeBeta-secretase 1Homo sapiens (human)
late endosomeBeta-secretase 1Homo sapiens (human)
multivesicular bodyBeta-secretase 1Homo sapiens (human)
endoplasmic reticulum lumenBeta-secretase 1Homo sapiens (human)
Golgi apparatusBeta-secretase 1Homo sapiens (human)
trans-Golgi networkBeta-secretase 1Homo sapiens (human)
plasma membraneBeta-secretase 1Homo sapiens (human)
synaptic vesicleBeta-secretase 1Homo sapiens (human)
cell surfaceBeta-secretase 1Homo sapiens (human)
endosome membraneBeta-secretase 1Homo sapiens (human)
membraneBeta-secretase 1Homo sapiens (human)
axonBeta-secretase 1Homo sapiens (human)
dendriteBeta-secretase 1Homo sapiens (human)
neuronal cell bodyBeta-secretase 1Homo sapiens (human)
membrane raftBeta-secretase 1Homo sapiens (human)
recycling endosomeBeta-secretase 1Homo sapiens (human)
Golgi-associated vesicle lumenBeta-secretase 1Homo sapiens (human)
hippocampal mossy fiber to CA3 synapseBeta-secretase 1Homo sapiens (human)
endosomeBeta-secretase 1Homo sapiens (human)
plasma membraneBeta-secretase 1Homo sapiens (human)
trans-Golgi networkBeta-secretase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID1080680Antifungal activity against Cladosporium cladosporioides NBRC 6348 assessed as diameter of mycelial growth at 5 ug/cm'2 at 25.5 degC after 20 days2009Journal of agricultural and food chemistry, Jul-08, Volume: 57, Issue:13
Bioactivity of latifolin and its derivatives against termites and fungi.
AID756489Cytotoxicity against mouse RAW264.7 cells by CCK assay2013Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14
Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages.
AID1080678Antifungal activity against Fomitopsis palustris NBRC 30339 assessed as diameter of mycelial growth at 5 ug/cm'2 at 25.5 degC after 14 days2009Journal of agricultural and food chemistry, Jul-08, Volume: 57, Issue:13
Bioactivity of latifolin and its derivatives against termites and fungi.
AID1080676Antifeedant activity against Reticulitermes speratus in compound pretreated paper disks assessed as mass loss of the paper disk at 3% measured after 14 days (Rvb = 7.67 mg)2009Journal of agricultural and food chemistry, Jul-08, Volume: 57, Issue:13
Bioactivity of latifolin and its derivatives against termites and fungi.
AID1153325Inhibition of BACE1 (unknown origin) expressed in CHO cells coexpressing human APP gene assessed as inhibition of beta-amyloid synthesis2014Bioorganic & medicinal chemistry letters, Jul-01, Volume: 24, Issue:13
β-Secretase (BACE1)-inhibiting C-methylrotenoids from Abronia nana suspension cultures.
AID1080682Antifungal activity against Fomitopsis palustris NBRC 30339 assessed as mycelial growth inhibition at 5 ug/cm2 at 25.5 degC after 14 days2009Journal of agricultural and food chemistry, Jul-08, Volume: 57, Issue:13
Bioactivity of latifolin and its derivatives against termites and fungi.
AID756490Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay2013Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14
Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages.
AID1080679Antifungal activity against Rhizopus oryzae NBRC 31005 assessed as mycelial growth inhibition at 5 ug/cm'2 at 25.5 degC after 36 hr2009Journal of agricultural and food chemistry, Jul-08, Volume: 57, Issue:13
Bioactivity of latifolin and its derivatives against termites and fungi.
AID1080681Antifungal activity against Trametes versicolor NBRC 30340 assessed as mycelial growth inhibition at 5 ug/cm'2 at 25.5 degC after 5 days2009Journal of agricultural and food chemistry, Jul-08, Volume: 57, Issue:13
Bioactivity of latifolin and its derivatives against termites and fungi.
AID1080677Antifungal activity against Trametes versicolor NBRC 30340 assessed as diameter of mycelial growth at 5 ug/cm'2 at 25.5 degC after 5 days2009Journal of agricultural and food chemistry, Jul-08, Volume: 57, Issue:13
Bioactivity of latifolin and its derivatives against termites and fungi.
AID1080675Antitermite activity against Reticulitermes speratus in compound pretreated paper disks assessed as mortality at 3% measured after 14 days2009Journal of agricultural and food chemistry, Jul-08, Volume: 57, Issue:13
Bioactivity of latifolin and its derivatives against termites and fungi.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's4 (50.00)24.3611
2020's3 (37.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.16

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.16 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index5.35 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.16)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]